A5025852625- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Adrenal Hormones and Disorders
- TGF-β signaling in diseases
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Neuroendocrine Tumor Research Advances
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Spinal Dysraphism and Malformations
- Venous Thromboembolism Diagnosis and Management
- PI3K/AKT/mTOR signaling in cancer
- Fetal and Pediatric Neurological Disorders
- Glycosylation and Glycoproteins Research
- Oral and Maxillofacial Pathology
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Cerebrovascular and genetic disorders
- Neurofibromatosis and Schwannoma Cases
- Management of metastatic bone disease
Shanghai Clinical Research Center
2020-2024
Huashan Hospital
2015-2024
Fudan University
2015-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2024
Shanghai Cancer Institute
2015-2024
State Key Laboratory of Medical Neurobiology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Shanghai Medical College of Fudan University
2012-2021
Creative Commons
2015
Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of corticotrophin-dependent syndrome cases. However, the genetic alterations in this disease are unclear. Here, we performed whole-exome sequencing DNA derived from 12 ACTH-secreting PAs and matched blood samples, which revealed three types somatic mutations a candidate gene, USP8 (encoding ubiquitin-specific protease 8),...
Cushing's disease results from corticotroph adenomas of the pituitary that hypersecrete adrenocorticotropin (ACTH), leading to excess glucocorticoid and hypercortisolism. Mutations deubiquitinase gene USP8 occur in 35-62% adenomas. However, major driver mutations wild-type tumors remain elusive. Here, we report recurrent USP48 (predominantly encoding p.M415I or p.M415V; 21/91 subjects) BRAF (encoding p.V600E; 15/91 with USP8. Similar mutants, both mutants enhance promoter activity...
Abstract Objective To review experience regarding the treatment of prolactinomas by endoscopic endonasal surgery focusing on association between presurgical dopamine agonist (DA) and perioperative outcomes, surgical morbidities, endocrine pathological characteristics. Methods A single-center series 290 cases was analyzed retrospectively clinical data were collected. Intratumoral collagen content assessed Masson trichrome staining. Results Tenacious tumor consistency (27.8% vs 9.8%, P...
Therapeutic effects of presurgical long-acting octreotide treatment on tumor shrinkage, and short- long-term postoperative GH IGF-1 levels acromegaly patients with invasive pituitary macroadenomas were investigated prospectively in Huashan Hospital, Shanghai, China. Thirty-nine untreated patients, all macroadenomas, randomly divided into two groups: experimental group (n=19), control (n=20). Patients the received a three-month course before transsphenoidal surgery; underwent surgery...
Skull base chordoma (SBC) is a bone cancer with high recurrence rate, radioresistance and poorly understood mechanism. Here, we profiled the transcriptomes of 90,691 single cells, revealed SBC cellular hierarchies, explored novel treatment targets. We identified cluster stem-like cells that tended to be distributed in inferior part tumor. Combining radiated UM-Chor1 RNA-seq data vitro validation, further found this cell marked by cathepsin L (CTSL), gene involved packaging telomere ends, may...
OBJECTIVE To evaluate the applicability of low-field intraoperative magnetic resonance imaging (iMRI) during transsphenoidal surgery pituitary macroadenomas. METHODS Fifty-five surgeries were performed for macroadenomas (modified Hardy's Grade II–IV) resections. All surgical processes guided by real-time updated contrast T1-weighted coronal and sagittal images, which acquired with 0.15 Tesla PoleStar N20 iMRI (Medtronic Navigation, Louisville, CO). The definitive benefits as well major...
Background There are few studies of the incidence and clinical characteristics pituitary apoplexy (PA) in adenoma patients, findings have been inconsistent. Objective The aim study was to retrospectively assess incidence, presentation, surgical management postoperative complications PA patients. Methods A database specifically designed collect clinical, therapeutic, prognostic histological information about Using multivariate logistic regression, odds ratios (ORs) with 95% confidence...
We aim to study surgical technique and analyze the related factors affecting tumor total removal postoperative endocrinological remission for endoscopic endonasal pituitary adenomas surgery.We retrospectively analyzed 178 surgery from March 2011 May 2014. Endonasal approach included routine transnasal-sphenoidal approach, transnasal- maxillary sinus in four cases transnasal-clivus one case.According imaging data endocrine examination results, was achieved 129 patients (72.5%), 38 with...
PurposeTo describe and predict the risk of venous thromboembolism (VTE) after surgical resection major sellar region tumors.MethodPatients with tumors were identified from a database. The outcome was VTE, including deep vein thrombosis (DVT) pulmonary embolism (PE) within 60 days surgery. We trained regression machine learning models to using baseline characteristics, findings postoperative laboratory tests.ResultsAmong 3818 patients included, 124 developed VTE total 60-day incidence 3.2 %,...
To evaluate the overall therapeutic effectiveness of transsphenoidal microsurgery for pituitary adenomas and explore surgical technique, application new technology, postoperative follow-up.The clinical presentation, imaging features, endocrine examination, pathological types, conditions operation, complications, follow-up 4050 patients with who had undergone from December 1981 to January 2004 were analyzed retrospectively.During past 6 years, total tumor resection (under microscope) has been...
Nonfunctioning pituitary adenoma (NFPA) and growth hormone (GHPA) are major subtypes of adenomas (PAs). The primary treatment is surgical resection. However, radical excision remains challenging, few effective medical therapies available. It urgent to find novel targets for the treatment. Bromodomain-containing protein 4 (BRD4) an epigenetic regulator that leads aberrant transcriptional activation oncogenes. Herein, we investigated pathological role BRD4 evaluated effectiveness inhibitors in...
Predicting the efficacy of long-acting somatostatin analogues (SSA) remains a challenge. We aim to quantitatively evaluate predictive value octreotide suppression test (OST) in short-term SSA active acromegaly. Sixty-seven newly diagnosed acromegaly patients were assessed with OST. Subsequently, all treated for 3 months, followed by reassessment. Nine parameters tested, including GHn (the nadir GH during OST), ΔGH1 (= [GH0h-GHn]/GH0h, GH0h was baseline ΔGH2 [GHm-GHn]/GHm, GHm mean on day...
Background: Surgical treatment of complex giant pituitary adenomas (GPAs) presents significant challenges. The efficacy and safety combining transsphenoidal transcranial approaches for these tumors remain controversial. In this largest cohort patients with GPAs, we compared the surgical outcomes between those undergoing a combined regimen non-combined regimen. We also examined differences in risks complications, costs, logistics two groups, which might offer valuable information appropriate...
Detection of the huge amount data generated in real-time visual evoked potential (VEP) requires labor-intensive work and experienced electrophysiologists. This study aims to build an automatic VEP classification system by using a deep learning algorithm.Patients with sellar region tumor optic chiasm compression were enrolled. Flash monitoring was applied during surgical decompression. Sequential images fed into three neural network algorithms train models.We included 76 patients. During...
OBJECTIVE The primary aim of this study was to investigate the value multidisciplinary team (MDT) management in treating patients with Cushing’s disease (CD). secondary assess concordance bilateral inferior petrosal sinus sampling (BIPSS) lateralization intraoperative observations. METHODS authors recruited 124 consecutive (128 procedures) who had undergone endoscopic endonasal resection adrenocorticotropic hormone–secreting pituitary adenomas from May 2014 April 2018 and assessed their...