A5065230273- Axon Guidance and Neuronal Signaling
- Groundwater and Isotope Geochemistry
- Tracheal and airway disorders
- Radioactivity and Radon Measurements
- Airway Management and Intubation Techniques
- Cancer-related gene regulation
- Craniofacial Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Geochemistry and Geologic Mapping
- Management of metastatic bone disease
- Cleft Lip and Palate Research
- Methane Hydrates and Related Phenomena
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Adrenal and Paraganglionic Tumors
- Oral microbiology and periodontitis research
- Cancer Immunotherapy and Biomarkers
- Groundwater flow and contamination studies
- Angiogenesis and VEGF in Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Wnt/β-catenin signaling in development and cancer
- Immune cells in cancer
- Spine and Intervertebral Disc Pathology
- Paleontology and Stratigraphy of Fossils
Nanjing University
2016-2025
Nankai University
2023-2025
Shandong First Medical University
2022-2024
State Key Laboratory of Continental Dynamics
2024
Shandong Provincial Hospital
2024
Northwest University
2024
Xi'an University of Science and Technology
2023
Shandong Tumor Hospital
2023
Nantong University
2021
Fudan University Shanghai Cancer Center
2018
Objectives: Integrins, the coordinator of extracellular and intracellular signaling, are often found to be aberrant in tumors can reshape tumor microenvironment. Although previous studies showed that integrin beta 2 (ITGB2) is important for host defense, its expression profile role tumors, especially cancer associated fibroblasts (CAFs) still unknown. Methods: Immunofluorescence stain fluorescence activated cell sorting were used analyze ITGB2 oral squamous carcinoma (OSCC). RT-PCR western...
CD68 has been widely used as a pan-macrophage marker for tumor-associated macrophages (TAM) which always involve in carcinogenesis. But the correlations between CD68(+) TAMs and prognosis of patients show to be inconsistent, might due lack specific markers TAMs. We here found that microlocalization also played unique role with oral squamous cell carcinoma (OSCC). were identified paraffin-embedded OSCC specimens (n = 91) by using immunohistochemistry. The number was remarkably increased from...
Abstract Resistance towards chemotherapy is a common complication in treatment of oral cancers, which leads to failure and poor outcome. In recent years, growing body evidence has shown that tumour hypoxia significantly contributes chemoresistance. Metformin, widely used hypoglycaemic drug, can reportedly potentiate the efficacy chemotherapeutic drugs various cancers; however, underlying mechanisms are intricate have not been fully understood. this study, we explored role metformin...
Orofacial inflammatory pain is a difficult clinical problem, and the specific molecular mechanisms for this remain largely unexplained. The present study aimed to determine differential expression of microRNAs (miRNAs) disclose underlying role miR-125a-3p in orofacial induced by complete Freund's adjuvant (CFA). Thirty-two differentially expressed miRNAs were first screened using microarray chip ipsilateral trigeminal ganglions (TGs) following CFA injection into skin innervated nerve,...
Measurements have been performed in a low-speed high-reaction single-stage axial compressor. Data obtained within and downstream of the rotor, when correlated with results other investigations, provide link between existence suction surface–hub corner separations, their associated loss mechanisms, blade loading. Within stator, it has shown that introducing small clearance stator stationary hub increases efficiency compared to case no clearance. Oil flow visualizaton indicated leakage reduced...
Abstract Opioid‐induced hyperalgesia and analgesic tolerance can lead to dose escalation inadequate pain treatment with μ‐opioid receptor agonists. Opioids cause tonic activation of glutamate NMDA receptors ( NMDAR s) at primary afferent terminals, increasing nociceptive input. However, the signaling mechanisms responsible for opioid‐induced pre‐synaptic s in spinal dorsal horn remain unclear. In this study, we determined role MAPK caused by chronic morphine administration. Whole‐cell...
Background: Sleep deprivation (SD) is a common condition affecting many people in modern life. Edaravone (Eda) neuroprotective drug, but whether it can improve cognitive impairment caused by SD remains unclear. Methods: Animals received oral gavage doses of Eda (10, 20, and 40 mg/kg) for 8 5 days before during SD. Starting from the 6th day, modified multiple platform model was used to produce mice 72 h. The Lashley III maze evaluating spatial learning memory. Malondialdehyde (MDA)...
Abnormal liver function is common post-surgery and linked to poor prognosis. We investigated whether intraoperative subanesthetic esketamine could improve postoperative recovery quality by reducing surgery-induced inflammation in patients with head neck squamous cell carcinoma (HNSCC). In this randomized controlled trial, 172 hNSCC were randomly assigned receive or saline intravenously. The primary outcome was serum alanine aminotransferase (ALT) on day (POD) 1. Secondary outcomes included...
<i>Background:</i> Over- or underexpression of certain Eph receptors has been associated with tumorigenesis some types cancer. <i>EphB1</i> is a member receptor tyrosine kinases the EphB subfamily involved in development, progress and prognosis colorectal cancers. The expression levels EphB1 colon cancer cell lines human carcinoma specimens were determined association clinicopathological parameters was analyzed. <i>Methods:</i> Quantitative real-time...
<i>Objective:</i><i>EphB1</i> is a member of the Eph family receptor tyrosine kinases that involved in embryonic nervous and vascular system development. Over- or underexpression certain receptors has been found some cancer samples compared to normal tissue. Expression related malignant transformation, metastasis, differentiation, prognosis cancers. Recently, EphB subfamily shown be tumorigenesis colorectal cancer. In present study, expression EphB1 transcript protein...
Advanced oral squamous cell carcinoma (OSCC) has large lesions and deep infiltration, the control of safe surgical margins was difficult. If residual tumor remains after incomplete resection, it can lead to local recurrence or even distant metastasis. This study sought investigate clinical application indocyanine green (ICG)-based near-infrared fluorescence (NIF) molecular imaging in intraoperative detection advanced OSCC.Twenty-nine patients with OSCC treated at First Ward Oral...
Abstract Eph receptors play important roles in the development of cancer. The present study aimed to investigate expression EphA1 and its clinicopathologic significance esophageal squamous cell carcinoma ( ESCC ). levels transcript protein were compared between matched normal mucosa same patient. High detected 25.6% (21/82) 23.2% (19/82) tumors with mucosa. up‐regulation was positively associated differentiation (p = 0.002), disease stage 0.034), lymph node metastasis 0.042). Increased more...