A5100685345- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Smart Grid and Power Systems
- Power Systems and Technologies
- Circular RNAs in diseases
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Cutaneous Melanoma Detection and Management
- Cancer Diagnosis and Treatment
- Power Systems and Renewable Energy
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Advanced Computational Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Angiogenesis and VEGF in Cancer
Shanghai Jiao Tong University
2011-2025
XinHua Hospital
2025
Hebei Medical University
2025
Hunan University of Traditional Chinese Medicine
2025
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2025
China General Nuclear Power Corporation (China)
2024
Qingdao Agricultural University
2024
Ruijin Hospital
2021-2023
Lung Institute
2023
To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery postoperative radiotherapy versus up-front in patients locally advanced resectable oral squamous cell carcinoma (OSCC).
Background Approximately 60–80% of patients with advanced head and neck squamous cell carcinoma (HNSCC) die within five years after diagnosis. Cisplatin-based chemotherapy is the most commonly used palliative treatment for these patients. To evaluate prognostic value X-linked inhibitor apoptosis (XIAP) level as a potential biomarker in patients, we investigated relationship between XIAP expression cisplatin response their prognosis. Methodology/Principal Findings Sixty HNSCC were recruited...
Oral mucosal melanoma (OMM) is a rare and aggressive subtype of with little known about its pathogenesis or carcinogenesis. We therefore performed whole-exome sequencing (WES) on 19 matched OMM tumor/normal pairs in order to gain insight into potential genetic drivers tumor formation. For the first time, we describe comprehensive mutational profile OMM. Our data suggest that background differs from those other subtypes. identified recurrent mutations involving KIT, POLE, PTPRD, PTCHD2,...
Background Cyclin D1 (CCND1) has been associated with chemotherapy resistance and poor prognosis. In this study, we tested the hypothesis that CCND1 expression determines response clinical outcomes in locally advanced head neck squamous cell carcinoma (HNSCC) patients treated neoadjuvant followed by surgery radiotherapy. Methodology Findings 224 HNSCC were either cisplatin-based radiotherapy (neoadjuvant group, n = 100) or (non-neoadjuvant 124). was assessed immunohistochemistry. levels...
Background Recent advances in novel targeted therapies have created the need for molecular characterization of cancer to allow accurate personalized treatments. In this study, our aim was investigate incidence activating mutations oncogenes BRAF , NRAS KIT and GNAQ / GNA 11 oral mucosal melanoma. Methods We analyzed a cohort 57 melanoma samples, including 27 frozen samples 30 formalin‐fixed paraffin‐embedded samples. The tumors were screened hotspot (exon 15), (exons 2 3), 9, 11, 13, 17), 5)...
// Lai-ping Zhong 1 , Chen-ping Zhang Guo-xin Ren Wei Guo William N. Jr 2 Christopher S. Hong 3 Jian Sun Han-guang Zhu Wen-yong Tu Jiang Li 4 Yi-li Cai Qiu-ming Yin Li-zhen Wang Zhong-he Yong-jie Hu Tong Ji Wen-jun Yang Wei-min Ye Jun Yue He Yan-an Li-qun Xu Zhengping Zhuang J. Jack Lee 5 Jeffrey Myers 6 and Zhi-yuan Department of Oral Maxillofacial-Head Neck Oncology, Ninth People’s Hospital, College Stomatology, Shanghai Jiao University School Medicine, China Thoracic/Head Medical...
Since the inhibitory immune checkpoint receptors have been described to benefit OSCC patients clinically, it is unknown that whether their expression in tumor microenvironment (TME) can determine clinical outcome response nimotuzumab therapy.We examined patterns of (including TIM-3, LAG-3, PD-L1, and CTLA-4) an immunoregulatory enzyme called IDO 36 during therapy by immunohistochemistry. Then, we divided recruited into responders non-responders according computed tomography (CT) scan...
Autophagy has a dual function in cancer, and its role carcinogenesis of the esophagus remains poorly understood. In present study, we explored prognostic value autophagy esophageal cancer (ESCA), one leading causes cancer-related deaths worldwide.Using ESCA RNA-sequencing (RNA-Seq) data from 158 primary patients with ESCA, including adenocarcinoma squamous cell carcinoma, were downloaded The Cancer Genome Atlas (TCGA) for this study. We obtained differentially expressed autophagy-related...
Pancreatic adenocarcinoma (PAAD) is a common malignancy with very low survival rate. More and more studies have shown that SPTAN1 may be involved in the development progression of variety tumors, including rectal cancer, adenocarcinoma, etc., affect their prognosis. Bioinformatics technology was used to analyze relationship between expression PAAD immune cell infiltration, regulatory factors chemokines, experiments were verify knock down migration, invasion, apoptosis cycle changes lines. In...
Increasing evidence highlights the critical roles of oxidative stress and endoplasmic reticulum (ER) in tumor initiation progression. However, specific functions related genes esophageal cancer (ESCA) remain poorly understood. To investigate impact ER on ESCA, this study analyzed TCGA GEO databases to identify 12 stress- stress-related differentially expressed (OERDEGs). Pathway analysis revealed significant enrichment processes such as PRC2-mediated methylation, stress-induced senescence,...
Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare, fatal, adult-onset neurodegenerative disease that most often caused by mutations affecting the colony stimulating factor-1 receptor (CSF-1R). To understand how CSF-1R-mutation affects human microglia – specialized brain-resident macrophages of central nervous system and downstream consequences for neuronal cells, we used macrophage forebrain organoid co-culture based on induced pluripotent stem cells generated...
Background Osteosarcoma (OTS) is aggressive bone malignancy without well-recognized prognosis biomarker. Tumor mutational burden (TMB) has been proved as effective biomarker in predicting clinical outcomes several cancer types. However, its prognostic value OTS remains unknown. In this study, we aim to evaluate the implication of TMB patients. Methods To depict landscape somatic mutations OTS, performed Whole-Exome Sequencing (WES) on 31 tissue samples and corresponding White Blood Cells...
Currently, the role of long noncoding RNA (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) in intervertebral disk degeneration (IDD) remains unclear. This study explored molecular mechanisms how lncRNA DGCR5 promoted human nucleus pulposus cells (NPCs) and pyroptosis during IDD. NPCs were identified by microscopic observation, flow cytometry, immunofluorescence. An vitro NPC model was induced using lipopolysaccharides treatment. SP600125 SB203580 used to inhibit c-Jun N-terminal...
Relapsed/refractory multiple myeloma (RRMM) and extramedullary (EMM) present significant challenges for patients with (MM) after their disease progresses.Despite notable advancements in treatments like autologous hematopoietic stem cell transplantation (ASCT) chimeric antigen receptor (CAR)-T-cell therapy, most RRMM EMM face a short survival period. Currently, there are no effective available. Allogeneic (allo-HSCT) is one of the treatment options MM. Reduced-intensity conditioning (RIC)...
Osteosarcoma (OS) is a malignant mesenchymal tissue tumor known to occur in children and adolescents, pulmonary metastasis often leads death these patients. The mechanism underlying OS progression remains unclear. Therefore, identifying new therapeutic targets treatment modalities for urgently needed. Abnormally expressed non-coding circular RNAs (circRNAs) are crucial the occurrence development of OS. purpose this study was explore expression role novel circRNA circ_000203 elucidate...
Abstract Background There is increasing evidence that circular RNAs (circRNAs) play a significant role in pathological processes including tumorigenesis. In contrast to exonic circRNAs, which are the most frequently reported circRNAs cancer so far, studies of intronic have been greatly lagged behind. Here, we aimed investigate regulatory head and neck squamous cell carcinoma (HNSCC). Methods We conducted whole‐transcriptome sequencing with four pairs primary tumor tissues adjacent normal...
Abstract The first gene therapy product, recombinant adenovirus human p53 (rAd- ), has been approved by CFDA since 2013. During these years, most of the clinical trials and relevant basic research were carried out Chinese oncologists. Gendicine was proved to be a safe promising drug for patients who suffered from head neck squamous cell carcinoma (HNSCC). therapeutic theories totally different traditional ones, such as surgeries or radio- chemotherapy, evaluation treatment outcomes should...
Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor. The specific pathological mechanism underlying disease initiation or progression remains unclear. Circular RNAs (circRNAs) are type of covalently circular RNA with head-to-tail junction site. In this study, we aimed to investigate the sponging between circRNAs microRNAs (miRNAs) in OS. Based on inhibited effect miR-16-5p reported OS, circUSP34 was analyzed as sponge via Starbase. We found that promoted...
An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in tumor development and progression. However, their involvement head neck squamous cell carcinoma (HNSCC) remains largely unknown. Epigenetic regulation is one major mechanism utilized by cancer cells to control lncRNA expression. We identified VENTXP1 was epigenetically silenced multiple types, its lower expression correlated with poorer survival HNSCC patients. Through silico analysis...
The aim of the present article was to review current new knowledge on molecular markers tumor invasion in ameloblastoma. In this review, were identified and allocated following six groups according their functions: (I) Markers involved extracellular matrix degradation, (II) Molecular cell adhesion lost, (III) bone remodeling, (IV) Cytokines angiogenesis, (V) related with function stromal cells ameloblastoma, (VI) proliferation invasion.In general, location within not quantitative assessments...
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the oromaxillofacial head and neck region is rare, with limited data available. This retrospective study explored clinical features, stage, treatment, prognosis this disease. Overall, 105 patients MALT lymphomas were included analysis. SPSS 22.0 software package was used for analysis a two-tailed P value ≤.05 considered statistically significant. Primary endpoints complete response (CR) rate,...
Recent high-throughput sequencing studies have revealed frequent CDK4 and TERT amplification in mucosal melanoma, suggesting that they are potential therapeutic targets. In this study, we investigated the statuses of head neck melanoma (HNMM) with aim providing preclinical data to support future clinical trials.In total, 29 HNMM samples were collected, including 16 oral (OMM) 13 nasal cavity/sinuses (SNMM) samples. Fluorescence situ hybridization was used analyze amplification,...