A5075909450- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Ultrasound and Hyperthermia Applications
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Colorectal and Anal Carcinomas
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Genomics and Phylogenetic Studies
- Lymphatic System and Diseases
- Oral Health Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- RNA Research and Splicing
- CNS Lymphoma Diagnosis and Treatment
Shanghai Jiao Tong University
2015-2025
Shanghai Ninth People's Hospital
2015-2025
National Clinical Research Center for Digestive Diseases
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Mucosal melanoma (MM), an aggressive rare subtype of melanoma, is distinct from cutaneous and has poor prognoses. We addressed the lack cell models for MM by establishing 30 organoids human oral (OMM), which retained major histopathological functional features parental tumors. Organoid groups derived chronologically or intratumorally lesions within same individual displayed heterogeneous genetics, expression profiles, drug responses, indicating rapid tumor evolution clinical response....
Epithelial-to-mesenchymal transition (EMT) confers cancer cells the ability of invasion and metastasis. However, how does EMT contribute to evasion immune surveillance is unclear, especially in salivary adenoid cystic carcinoma (SACC). In this study, we investigated molecular link between EGF-induced checkpoint ligand programmed death-ligand 1 (PD-L1) by immunoprecipitation (IP) Westernblot analysis. Cell migration activity was assayed transwell assay. Immunohistochemical (IHC) staining...
Since the inhibitory immune checkpoint receptors have been described to benefit OSCC patients clinically, it is unknown that whether their expression in tumor microenvironment (TME) can determine clinical outcome response nimotuzumab therapy.We examined patterns of (including TIM-3, LAG-3, PD-L1, and CTLA-4) an immunoregulatory enzyme called IDO 36 during therapy by immunohistochemistry. Then, we divided recruited into responders non-responders according computed tomography (CT) scan...
Background/Aims: Slug protein, a transcription factor for the induction of epithelial-mesenchymal transition (EMT) and cancer cell invasion metastasis, is frequently upregulated in human epithelial cancers. However, mutation this gene rare, mechanism its dysregulation remains unknown, especially head neck squamous carcinoma (HNSCC). Methods: We examined role TNF-α stabilization by immunoprecipitation-westernblot analysis. Migration HNSCC cells with or without knockdown expression was assayed...
Rationale: The oncogenesis of head and neck squamous cell carcinoma (HNSCC) is believed to result from oncogene activation tumor suppressor inactivation. Here, we identified a new oncogenic role for the EREG gene in HNSCC. Methods: TCGA database immunohistochemistry assay were used analyze expression HNSCC tissues. Immunoblotting was performed identify EGFR-mediated pathways altered by EREG. investigated vivo vitro. Results: Upregulated predicted poor prognosis triggered transformation...
ABSTRACT Objectives The option is rare for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) failed to prior‐line immune checkpoint inhibitors (ICIs) cetuximab‐based treatment. efficacy of salvage therapy was unsatisfied. Materials Methods We collected the clinical data R/M HNSCC progressed from immunotherapy cetuximab therapy, retrospectively analyzed toxicity anlotinib‐based in these patients. Results In total, 24 eligible participants were accrued...
Objectives: Cetuximab-based therapy is prone to develop skin complications. Our study aims identify the impact on central venous access by cetuximab-based in patients with head and neck squamous cell carcinoma (HNSCC). Methods: We conducted a single center retrospective explore prevalence type of complications between totally implantable port (TIVP) implanted subcutaneous tissue anterior chest wall peripherally inserted catheter (PICC) for HNSCC who received therapy. Results: In current...
Irisin is a newly discovered factor that secreted by skeletal muscle and plays an important role in the homeostasis metabolism of energy balance. This study used irisin radiolabeled with <sup>125</sup>I small-animal SPECT/CT imaging to investigate metabolic elimination distribution vivo. was labeled using Iodogen method. Small-animal performed on C57/B16 mice at 15, 30, 60, 120, 240 min after receiving tail vein injection, radioactive organs determined 120 min. revealed highest level...
Abstract Background Recent evidence suggested a potential correlation between BMI and the efficacy of immune checkpoint inhibitors in cancer patients. This study aimed to evaluate prognostic value body mass index (BMI) recurrent/metastatic head neck squamous cell carcinoma (R/M HNSCC) patients treat with pembrolizumab. Methods The current retrospective cohort enrolled 49 R/M HNSCC underwent at least one cycle pembrolizumab as second‐line treatment from June 2018 October 2020. Survival...
Mucosal melanoma (MM) is a rare but devastating subtype of melanoma. Our previous studies have demonstrated robust anti-tumor effects cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors in head and neck MM (HNMM) patient-derived xenograft models with CDK4 amplification. Herein, we aimed to investigate the efficacy safety dalpiciclib (SHR6390), CDK4/6 inhibitor, HNMM patients harboring
Abstract Background There is increasing evidence that circular RNAs (circRNAs) play a significant role in pathological processes including tumorigenesis. In contrast to exonic circRNAs, which are the most frequently reported circRNAs cancer so far, studies of intronic have been greatly lagged behind. Here, we aimed investigate regulatory head and neck squamous cell carcinoma (HNSCC). Methods We conducted whole‐transcriptome sequencing with four pairs primary tumor tissues adjacent normal...
Pembrolizumab with cisplatin and 5-fluorouracil showed survival benefit but relatively high occurrence of treatment-related adverse events (TRAEs) for recurrent/metastatic oral squamous cell carcinoma (R/M OSCC). A more tolerable regime is needed. This trial enrolled 20 R/M OSCC patients previously untreated PD-L1 positive. Patients were administered camrelizumab docetaxel every 3 weeks six cycles, followed by monotherapy until disease progression or intolerable toxicity. The primary...
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the oromaxillofacial head and neck region is rare, with limited data available. This retrospective study explored clinical features, stage, treatment, prognosis this disease. Overall, 105 patients MALT lymphomas were included analysis. SPSS 22.0 software package was used for analysis a two-tailed P value ≤.05 considered statistically significant. Primary endpoints complete response (CR) rate,...
Mucosal melanoma has characteristically distinct genetic features and typically poor prognosis. The lack of representative mucosal models, especially cell lines, hindered translational research on this subtype. In study, we aimed to establish provide the biological properties, genomic pharmacological profiles a line that would contribute understanding treatment optimization molecularly-defined
The KEYNOTE-048 and KEYNOTE-040 study have demonstrated the efficacy of pembrolizumab in recurrent or metastatic squamous cell carcinoma head neck (R/M HNSCC), we conducted this real-world to investigate patients with R/M HNSCC.
Abstract Mucosal melanoma (MM) is a rare and aggressive form of with poorer prognosis compared to other subtypes. Recent large-scale next-generation sequencing studies, including our own research, have demonstrated that the molecular characteristics potential oncogenic drivers MM differ significantly from those cutaneous melanoma. The emergence selective CDK4/6 inhibitors, already approved for use in breast cancer undergoing phase III clinical trials solid tumors, represents promising...