A5088469791- Supramolecular Self-Assembly in Materials
- Genetics, Aging, and Longevity in Model Organisms
- Environmental Toxicology and Ecotoxicology
- Gut microbiota and health
- Supramolecular Chemistry and Complexes
- Oral Health Pathology and Treatment
- Advanced biosensing and bioanalysis techniques
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Glycosylation and Glycoproteins Research
- Advanced Polymer Synthesis and Characterization
- Fibroblast Growth Factor Research
- Recycling and utilization of industrial and municipal waste in materials production
- Head and Neck Cancer Studies
- Luminescence and Fluorescent Materials
- Anaerobic Digestion and Biogas Production
- Cancer Immunotherapy and Biomarkers
- Porphyrin Metabolism and Disorders
- Mesenchymal stem cell research
- Intraperitoneal and Appendiceal Malignancies
- Geotechnical Engineering and Underground Structures
- ATP Synthase and ATPases Research
Nanjing Medical University
2025
Yangpu Hospital of Tongji University
2025
Inner Mongolia Medical University
2025
Shanghai Ninth People's Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
Changsha Hospital for Maternal and Child Health Care
2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Ministry of Ecology and Environment
2020-2024
Nanjing Institute of Environmental Sciences
2020-2024
National Clinical Research
2024
Vesicles breathe CO2! A new type of vesicle that self-assembles from amidine-containing diblock copolymer displays “breathing” features. Treating the vesicles with CO2 or Ar can reversibly tune expansion and contraction vesicular volume, as if a bubble is breathing (see picture, PAD=poly((N-amidino)dodecyl acrylamide), PEO=poly(ethylene oxide), Rh=hydrodynamic radius). Detailed facts importance to specialist readers are published ”Supporting Information”. Such documents peer-reviewed, but...
Targeting organelles by modulating the redox potential of mitochondria is a promising approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks selectivity because perform essential functions for (almost) all cells. We show enzyme-instructed self-assembly (EISA), bioinspired molecular process, selectively generates assemblies modulators (e.g., triphenyl phosphinium (TPP)) in pericellular space uptake, which allows targeting The attachment TPP pair enantiomeric,...
Patient-derived organoids (PDOs) have emerged as a promising platform for clinical and translational studies. A strong correlation exists between outcomes the use of PDOs to predict efficacy chemotherapy and/or radiotherapy. To standardize interpretation enhance scientific communication in field cancer precision medicine, we revisit concept PDO-based drug sensitivity testing (DST). We present an expert consensus-driven approach medication selection aimed at predicting patient responses....
Abstract Anticancer drug resistance demands innovative approaches that boost the activity of drugs against drug‐resistant cancers without increasing systemic toxicity. Here we show use enzyme‐instructed self‐assembly (EISA) to generate intracellular supramolecular assemblies drastically cisplatin ovarian cancer cells. We design and synthesize small peptide precursors as substrates carboxylesterase (CES). CES cleaves ester bond pre‐installed on form peptides self‐assemble in water nanofibers....
Cancer cells differ from normal in both gain of functions (i.e., upregulation) and loss downregulation). While it is common to suppress function for chemotherapy, remains challenging target downregulation cancer cells. Here we show the combination enzyme-instructed assembly disassembly by designing peptidic precursors as substrates carboxylesterases (CESs) alkaline phosphatases (ALPs). The turn into self-assembling molecules form nanofibrils upon dephosphorylation ALP, but CES-catalyzed...
Two homopolymers can orthogonally self-assemble into pseudo-copolymer based on terminal host–guest interactions, and these supramolecular copolymers further fabricate one-dimensional nanotubes in water. By applying alternate UV/visible light, the aggregates reversibly assemble disassemble by means of association disassociation active connection.
Abstract Background While observational studies and experimental data suggest a link between oral lichen planus (OLP) cavity cancer (OCC), the causal relationship role of inflammatory cytokines remain unclear. Methods This study employed univariable multivariable Mendelian Randomization (MR) analysis to investigate OLP risk OCC. Additionally, potential in modulating this association was explored. Instrumental variables were derived from genetic variants associated with ( n = 377,277)...
Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease characterized by pain and inflammation. Clobetasol propionate (CLO) the first-line drug in treatment of OLP. The meta-analysis aimed to evaluate efficacy safety CLO for treating patients with Methods PubMed, Embase Web Science were systematically searched from database inception date up August 2023. There no restrictions on language or publication. outcomes our interest as follows: improvement clinical...
Vesikel atmen CO2! Ein neuer Vesikeltyp, der sich aus Amidin-haltigen Diblockcopolymeren selbstorganisiert, "atmet". Werden die mit CO2 oder Ar behandelt, resultiert eine reversible Expansion und Kontraktion des Vesikelvolumens, ähnlich wie bei einer Luftblase (siehe Bild, PAD=Poly((N-amidino)dodecylacrylamid), PEO=Polyethylenoxid, Rh=hydrodynamischer Radius). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
Higher-order assemblies of proteins, with a structural and dynamic continuum, is an important concept in biology, but these insights have yet to be applied designing biomaterials. Dynamic supramolecular phosphoglycopeptides (sPGPs) transform 2D cell sheet into 3D spheroids. A ligand-receptor interaction between glycopeptide phosphopeptide produces sPGPs that form nanoparticles, which nanofibrils upon partial enzymatic dephosphorylation. The dynamically hierarchically situ on the surface,...
Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death worldwide. Accumulating researches have highlighted ability exosome-encapsulated microRNAs (miRNAs or miRs) as potential circulating biomarkers for cancer. The current study aimed to evaluate significance mesenchymal stem cells (MSCs)-derived exosomal miR-204 in invasion, migration, and epithelial-mesenchymal transition (EMT) NSCLC cells. Initially, expression human tissues was determined by RT-qPCR, which...
A class of dialkoxyanthracene-containing diblock copolymers is synthesized which possesses visible light-responsivity. These can self-assemble into a micellar structure in water. Green light (540 nm) able to scissor these anthracene species and cleave the copolymer two fragments, inducing disassembly self-assembled micelles.
Abstract Anticancer drug resistance demands innovative approaches that boost the activity of drugs against drug‐resistant cancers without increasing systemic toxicity. Here we show use enzyme‐instructed self‐assembly (EISA) to generate intracellular supramolecular assemblies drastically cisplatin ovarian cancer cells. We design and synthesize small peptide precursors as substrates carboxylesterase (CES). CES cleaves ester bond pre‐installed on form peptides self‐assemble in water nanofibers....
Mutation in oxysterol-binding protein-like 2 ( OSBPL2) has been identified as the genetic cause of autosomal dominant nonsyndromic hearing loss (DFNA67, OMIM No. 616340). However, pathogenesis OSBPL2 mutation DFNA remains unclear. Our previous work showed that deficiency impaired cell adhesion auditory HEI-OC1 cells. In addition, hair cells (HCs) and morphological abnormalities HC stereocilia were detected OSBPL2-disrupted pigs, suggesting plays an important role regulation actin...
We study the use of post-self-assembly cross-linking to combine molecular nanofibers hydrogelators with copolymers generate oscillatory materials using Belousov-Zhabotinsky reaction. The formation from designed provides multiple polymerizable sites for copolymerizing N-isopropylacrylamide and attaching a catalytic ruthenium bipyridine complex on copolymer. combination supramolecular self-assembly copolymerization offers versatile facile approach generating soft that have large pores in gel...
Reaction-diffusion (RD) is the most important inherent feature of living organism, but it has yet to be used for developing biofunctional nanoparticles (NPs). Here we show use chirality control RD NPs selectively inhibiting cancer cells. We observe that L-phosphotyrosine (L-pY) decorated (NP@L-pYs) are innocuous cells, D-pY ones (NP@D-pYs) inhibit Our study shows alkaline phosphatases (ALP), presented in culture and overexpressed on dephosphorylates NP@L-pYs much faster than NP@D-pYs. Such a...
Mucosal melanoma (MM) is a rare but devastating subtype of melanoma. Our previous studies have demonstrated robust anti-tumor effects cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors in head and neck MM (HNMM) patient-derived xenograft models with CDK4 amplification. Herein, we aimed to investigate the efficacy safety dalpiciclib (SHR6390), CDK4/6 inhibitor, HNMM patients harboring
The excessive application and loss of pesticides poses a great risk to the ecosystem, environmental safety assessment is time-consuming expensive using traditional animal toxicity tests. In this work, pesticide acute dataset was created for silkworm integrating extensive experiments various common formulations considering sensitivity adverse environment, its economic value in China, gap machine learning (ML) research on prediction species, which addressed previous limitation only being able...