A5008404877- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Kruppel-like factors research
First Affiliated Hospital of Gannan Medical University
2021-2023
Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death worldwide. Accumulating researches have highlighted ability exosome-encapsulated microRNAs (miRNAs or miRs) as potential circulating biomarkers for cancer. The current study aimed to evaluate significance mesenchymal stem cells (MSCs)-derived exosomal miR-204 in invasion, migration, and epithelial-mesenchymal transition (EMT) NSCLC cells. Initially, expression human tissues was determined by RT-qPCR, which...
Abstract Background The RING finger (RNF) proteins are a large group of ubiquitin ligases whose aberrant expression is often associated with disease progression. This study examines the function RNF protein 182 (RNF182) in lung adenocarcinoma (LUAD) cells and its impact on p65 programmed death ligand 1 (PDL1) regulation. Methods Expression RNF182, p65, PDL1 LUAD tissues was measured using immunohistochemistry, reverse transcription quantitative polymerase chain reaction (RT‐qPCR), and/or...