A5053332711- Bone Tissue Engineering Materials
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Nanoplatforms for cancer theranostics
- Bone Metabolism and Diseases
- Sarcoma Diagnosis and Treatment
- Bone fractures and treatments
- Total Knee Arthroplasty Outcomes
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Medical Imaging and Analysis
- Dental Implant Techniques and Outcomes
- Hip disorders and treatments
- 3D Printing in Biomedical Research
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Titanium Alloys Microstructure and Properties
- Advanced Nanomaterials in Catalysis
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Anatomy and Medical Technology
- Bone Tumor Diagnosis and Treatments
- Pelvic and Acetabular Injuries
- Bone health and treatments
- Bone and Joint Diseases
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2016-2025
Jiangsu University
2025
First People's Hospital of Kunshan
2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Chongqing Medical University
2023
Harbin Medical University
2023
Second Affiliated Hospital of Harbin Medical University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
First Hospital of Shanxi Medical University
2023
Abstract Sonodynamic therapy (SDT) is noninvasive and possesses high body‐penetration depth, showing great potential for the treatment of deep‐seated solid tumors. The efficacy SDT, however, limited by widespread hypoxia in Given this, an ultrasound‐activated nanosystem developed integrating ferrate(VI) protoporphyrin IX into biodegradable hollow mesoporous organosilica nanoplatforms, followed assembling a phase‐change material lauric acid. effectively reacts with water as well overexpressed...
Trace elements play important roles in human health, but little is known about their functions humoral immunity. Here, we show an role for iron inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the measles vaccine when compared iron-normal controls. Mice with deficiency also attenuated T-dependent or T-independent antigen-specific responses. essential proliferation; both α-ketoglutarate inhibition could...
Abstract Cancer metastases are the main causes for high mortality of cancer. The current treatment modality bone metastasis breast cancer is dominantly destructive, which urges engineering multifunctional biomaterials, not only eliminating primary/metastases tumors effectively but also enhancing bone–tissue regeneration. Herein, an immune adjuvant (R837)‐loaded and niobium carbide (Nb 2 C) MXene‐modified 3D‐printing biodegradable scaffold (BG@NbSiR) designed constructed to treat engineered...
Abstract Antibacterial and osteogenic design is required for ideal orthopedic implants. The excellent antimicrobial performance of silver nanoparticles (AgNPs) has attracted interest the treatment implant‐related infections. However, dose‐dependent cytotoxicity its negative impact on bone implants restrict further use AgNPs coatings. Therefore, a hybrid coating containing polydopamine (PDA), hydroxyapatite (HA), AgNPs, chitosan (CS) prepared. Organic chelators CS PDA that have promising...
Tumor microenvironment (TME) plays an important role in the tumor progression. Among TME components, cancer-associated fibroblasts (CAFs) show multiple tumor-promoting effects and can induce immune evasion drug-resistance. Regulating CAFs be a potential strategy to augment systemic anti-tumor immunity. Here, study observes that hydrogen treatment alleviate intracellular reactive oxygen species of reshape CAFs' immune-suppressive phenotypes. Accordingly, controllable TME-responsive therapy...
Objectives: To assess the feasibility and safety of using health-promoting traditional Chinese exercise, known as Baduanjin, in treating knee osteoarthritis (OA). Subjects: Twenty-eight (28) female patients who met American College Rheumatology criteria for signed informed consent were randomized into Baduanjin group (n = 14) control 14). Eleven (11) 10 completed trial. Intervention: The exercised following taped commands community entertainment room during 30-minute classes five times a...
Increasing evidence suggests that the tumor microenvironment plays a key role in development of drug resistant cells. In this study, we tried to determine whether mesenchymal stem cells (MSCs) contribute increased chemoresistance osteosarcoma. We found exposure Saos-2 and U2-OS MSCs conditioned medium (CM) viable presence therapeutic concentrations doxorubicin or cisplatin. Meanwhile, MSC CM-associated pro-proliferative effects were accompanied by reduced caspase 3/7 activity Annexin V...
In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, mechanisms drug remain elusive, limiting therapeutic efficacy. Here, we set out explore relationship between dynamic histone changes and efficacy cisplatin against OS. First, found two demethylases associated with H3 lysine 27 trimethylation (H3K27me3) demethylation, KDM6A, KDM6B that were upregulated after treatment. Consistent clinical data,...
Abstract Osteosarcoma (OS) is a primary malignant bone tumour. However, the genetic basis for pathogenesis of OS remains elusive. In this study, we uncovered role histone methyltransferase NSD2 in regulating tumourigenesis and chemosensitivity OS. We show that knockdown leads to increased apoptosis cells vitro vivo. Additionally, significantly enhances efficacy cisplatin against accordingly inhibits properties associated with cancer stem (CSCs). Furthermore, RNA sequencing (RNAseq) Gene...
Abstract Osteosarcoma (OS) is the primary malignant bone tumor. Despite therapeutic strategies including surgery, chemotherapy, and radiotherapy have been introduced into war of fighting OS, 5‐year survival rate for patients still remains unchangeable decades. Besides, critical defects after drug‐resistance side effects also attenuate predict poor prognosis. Recently, photothermal therapy (PTT) has attracted extensive attention featuring minimal invasiveness high spatial‐temporal precision...
In this paper, the results of study on performance four groups different honeycomb structures show that application structure in design biomimetic bone scaffold is feasible and promising. terms static properties, elastic modulus (1.6–3 GPa) scaffolds matched human cancellous (0.1–4.5 GPa), yield strength (88–146 MPa) was much higher than femoral neck (0.56–3.71 MPa). permeability, except for excessive permeability SU scaffold, other three (1.5*10−8–4.8*10−8 m2) are all range...
As a critical factor involved in the maintenance of physiological homeostasis, gut microbiota (GM) reportedly plays key role bone development.To date, association between GM and steroid deficiency-induced osteoporosis remains poorly understood.Forty female Sprague Dawley rats were divided into an ovariectomy (OVX) or control group.We performed 16S rRNA metagenome sequencing, to compare diversity, taxonomic differences, functional genes.The composition did not change group number operational...
Recently, more interest has been paid to the association between bone mass and gut microecological dysbiosis.The results of clinical studies comparing microbiota (GM) in osteoporosis patients have inconsistent due different inclusion exclusion criteria.To date, GM senile remains poorly understood.Here, we utilized an aged rat model (22 months old) study composition function with by 16S rRNA metagenomic sequencing.The showed that there was a significant reduction alpha diversity F/B...
The rapid spread of infectious bacteria has brought great challenges to public health. It is imperative explore effective and environment-friendly antibacterial modality defeat antibiotic-resistant with high biosafety broad-spectrum property.Herein, biocompatible Cu3SnS4 nanoflakes (NFs) were prepared by a facile low-cost fabrication procedure. These NFs could be activated visible light, leading light-mediated photocatalytic generation myriad reactive oxygen species (ROS). Besides, the...