A5110041176- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Bone Metabolism and Diseases
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Bone fractures and treatments
- Periodontal Regeneration and Treatments
- 3D Printing in Biomedical Research
- Bone health and osteoporosis research
- Electrospun Nanofibers in Biomedical Applications
- Magnesium Alloys: Properties and Applications
- Titanium Alloys Microstructure and Properties
- Hip disorders and treatments
- Bone health and treatments
- Dental Implant Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Medical Imaging and Analysis
- Knee injuries and reconstruction techniques
- Virus-based gene therapy research
- Pelvic and Acetabular Injuries
- Spine and Intervertebral Disc Pathology
- Bone and Joint Diseases
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2016-2025
Wenzhou Medical University
2025
Dali University
2025
Southwest Jiaotong University
2021-2024
Ministry of Education of the People's Republic of China
2009-2022
Shanghai Institutes for Biological Sciences
2010-2020
Renji Hospital
2020
Shanghai Cell Therapy Research Institute
2020
Chinese Academy of Sciences
2009-2019
Abstract Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical properties than polymers, yet their strength is roughly less 350 MPa. In this work, binary Zn alloys with alloying elements Mg, Ca, Sr, Li, Mn, Fe, Cu, and Ag respectively, are screened systemically by in vitro vivo studies. Li exhibits the most effective strengthening role Zn, followed Mg. Alloying leads to accelerated degradation, but adequate integrity can be expected for when considering fracture...
Metallic implants with a low effective modulus can provide early load-bearing and reduce stress shielding, which is favorable for increasing in vivo life-span. In this research, porous Ti6Al4V scaffolds three pore sizes (300~400, 400~500, 500~700 μm) were manufactured by Electron Beam Melting, an elastic range of 3.7 to 1.7 GPa. Cytocompatibility vitro osseointegration ability assessed. hBMSCs numbers increased on all over time. The group intended 300 400 μm was significantly higher than...
Bone defects are commonly caused by severe trauma, malignant tumors, or congenital diseases and remain among the toughest clinical problems faced orthopedic surgeons, especially when of critical size. Biodegradable zinc-based metals have recently gained popularity for their desirable biocompatibility, suitable degradation rate, favorable osteogenesis-promoting properties. The biphasic activity Sr promotes osteogenesis inhibits osteoclastogenesis, which imparts Zn-Sr alloys with ideal...
The essential role of the neural network in enhancing bone regeneration has often been overlooked biomaterial design, leading to delayed or compromised healing. Engineered mesenchymal stem cells (MSCs)-derived exosomes are becoming increasingly recognized as potent cell-free agents for manipulating cellular behavior and improving therapeutic effectiveness. Herein, MSCs stimulated with nerve growth factor (NGF) regulate exosomal cargoes improve neuro-promotive potential facilitate innervated...
In this study, we prepared hydroxyapatite/bacterial cellulose (HAp/BC) nanocomposite scaffolds utilizing the biomimetic technique, and investigated proliferation osteoblastic differentiation of stromal cells derived from human bone marrow (hBMSC) on them. Scanning electron microscopy proved that could adhere spread scaffolds. The hBMSC seeded nanocomposites exhibited better adhesion activity than those upon pure BC. After 6 days culture scaffolds, proliferated faster BC, as assessed by...
Dexamethasone (Dex)-induced osteoporosis has been described as the most severe side effect in long-term glucocorticoid therapy. The decreased bone mass and increased marrow fat suggest that Dex possibly shifts differentiation of stromal cells (BMSCs) to favor adipocyte over osteoblast, but underlying mechanisms are still unknown. In this paper, we established a Dex-induced osteoporotic mouse model, found BMSCs from Dex-treated mice more likely differentiate into than those control mice, even...
// Mei Xin 1, * , Zhiguang Qiao 2, Jing Li 3, 4, Jianjun Liu 1 Shaoli Song Xiaoping Zhao Ping Miao Tingting Tang 2 Lei Wang Weichun 5 Xiaodi Yang 6 Kerong Dai 7 Gang Huang 8 Department of Nuclear Medicine, Renji Hospital, School Shanghai Jiao Tong University, 200127, China Key Laboratory Orthopaedic Implants, Orthopaedics, Ninth People’s 200011, 3 Bone and Joint Research Center, The First Affiliated Frontier Institute Science Technology, Xi’an Jiaotong 710061, 4 Alpert Medical...
Abstract Introduction miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, role it plays OA pathogenesis not clear. The aim this study to identify a molecular target miR-146a, thereby elucidating its function chondrocytes during pathogenesis. Methods Primary from Sprague-Dawley rats were treated with IL-1β before expression levels Smad4 and vascular endothelial growth factor (VEGF) quantified by real-time PCR and/or western...