A5100709230- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Total Knee Arthroplasty Outcomes
- Nanoplatforms for cancer theranostics
- Dental Implant Techniques and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Esophageal Cancer Research and Treatment
- Tissue Engineering and Regenerative Medicine
- Orthopedic Infections and Treatments
- Wound Healing and Treatments
- Knee injuries and reconstruction techniques
- Spinal Fractures and Fixation Techniques
- Advanced materials and composites
- Bone Metabolism and Diseases
- Dental Radiography and Imaging
- Additive Manufacturing and 3D Printing Technologies
- Mesenchymal stem cell research
- Muscle activation and electromyography studies
- Spine and Intervertebral Disc Pathology
- Anatomy and Medical Technology
- Graphene and Nanomaterials Applications
- Stroke Rehabilitation and Recovery
- Urinary Bladder and Prostate Research
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2016-2025
Shanghai Ocean University
2024
Southwest Jiaotong University
2021-2024
Ocean University of China
2024
Shanghai Sixth People's Hospital
2009-2024
Linzhou Cancer Hospital
2014-2024
Weifang Medical University
2022-2023
University of Shanghai for Science and Technology
2023
China State Shipbuilding (China)
2023
Malignant bone tumor is one of the major diseases. The treatment such a disease typically requires removal and regeneration tumor‐initiated defects simultaneously. To address this issue, it required that implanted biomaterials should combine bifunctions both therapy regeneration. In work, bifunctional graphene oxide (GO)‐modified β‐tricalcium phosphate (GO‐TCP) composite scaffold combining high photothermal effect with significantly improved bone‐forming ability prepared by 3D‐printing...
Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge clinical treatment because of dysfunction macrophage polarization and the inflammatory microenvironment region. Three-dimensional (3D) bioprinted scaffolds loaded live cells bioactive factors can improve cell viability further accelerating repair. Here, we used modified bioinks comprising gelatin, gelatin methacryloyl (GelMA), 4-arm poly (ethylene glycol) acrylate (PEG) to fabricate 3D containing BMSCs,...
Abstract Microchannel networks within engineered 3D scaffold can allow nutrient exchange and rapid blood vessels formation. However, fabrication of a bone microenvironment‐mimicking with hierarchical micro/nanofibrous microchannel structures is still challenge. Herein, inspired by structural functional cues remodeling, networks‐enriched nanofibrous using printing thermally induced phase separation techniques, which facilitate cells migration nutrients transportation, developed. The...
The favorable microstructure and bioactivity of tissue-engineered bone scaffolds are closely associated with the regenerative efficacy defects. For treatment large defects, however, most them fail to meet requirements such as adequate mechanical strength, highly porous structure, excellent angiogenic osteogenic activities. Herein, inspired by characteristics a "flowerbed", we construct short nanofiber aggregates-enriched dual-factor delivery scaffold via 3D printing electrospinning...
Abstract Non‐healing wound is a common complication of diabetic patients associated with high morbidity and mortality. Engineered therapeutic hydrogels have enviable advantages in tissue regeneration, however, they are suboptimal for the healing wounds characterized by reactive oxygen species (ROS) accumulation chronic hypoxia. Here, unique biological metabolism‐inspired hydrogel, ameliorating this hostile microenvironment, presented. Consisting natural polymers (hydrazide modified...
The resection of malignant osteosarcoma often results in large segmental bone defects, and the residual cells can facilitate recurrence. Consequently, treatment is a major challenge clinical practice. ideal goal for to eliminate it thoroughly, repair resultant defects as well avoid bacterial infections. Herein, we fabricated selenium/strontium/zinc-doped hydroxyapatite (Se/Sr/Zn-HA) powder by hydrothermal method, then employed with polycaprolactone (PCL) ink construct composite scaffolds...
The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal tumor tissues and regeneration defects, bifunctional three-dimensional (3D) scaffolds that function in both therapy tissue are expected to address this need. In study, novel (MS-AKT scaffolds) were successfully fabricated by combining 3D printing technique with hydrothermal method. During process, MoS2 nanosheets grown situ on strut surface bioceramic scaffolds, endowing...
The challenges in bone tumor therapy are how to repair the large defects induced by surgery and kill all possible residual cells. Compared cancellous defect regeneration, cortical regeneration has a higher demand for substitute materials. To best of our knowledge, there currently few bifunctional biomaterials with an ultra-high strength both regeneration. Here, we designed Fe-CaSiO3 composite scaffolds (30CS) via 3D printing technique. First, 30CS possessed high compressive that provided...
Biological regeneration of articular cartilage continues to be a challenge at present. Functional engineered implants with patient-specific sizes are difficult achieve. The aim this study is fabricate biocompatible cell-laden hydrogel designable structure. Covalent hydrogels were prepared water soluble hydroxybutyl chitosan (HBC) and oxidized chondroitin sulfate (OCS) via Schiff-base reaction. With the aid three-dimensional (3D) bioprinted sacrificial molds, HBC/OCS various structures...
Artificial construction from tendon to bone remains a formidable challenge in tissue engineering owing their structural complexity. In this work, bioinspired calcium silicate nanowires and alginate composite hydrogels are utilized as building blocks construct multiscale hierarchical bioactive scaffolds for versatile bone. By integrating 3D printing technology mechanical stretch post-treatment confined condition, the obtained possess reinforcement architectures nano- submicron- microscale...
Abstract The periosteum is a connective tissue membrane adhering to the surface of bone that primarily provides nutrients and regulates osteogenesis during development injury healing. However, building an artificial with good adhesion properties satisfactory for defect repair remains challenge, especially using three-dimensional (3D) bioprinting. In this study, dopamine was first grafted onto molecular chain gelatin N -(3-dimethylaminopropyl)- ′-ethylcarbodiimide hydrochloride...
The reconstruction of the vascular network is crucial step in bone regeneration. Therefore, effectively modulating angiogenesis-osteogenesis coupling tissue engineering scaffolds currently an urgent need. In this study, we employed silane agents containing double bonds to modify tetrahedral silicate, resulting preparation a photocurable precursor 45S5 bioactive glass (PG). PG was utilized as binding agent for tricalcium phosphate (TCP) powder, and one-step photocuring 3D printing approach...
Abstract Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected defects. Its recurrent resistant nature, high incidence rate, long‐term hospitalization, medical costs have driven efforts of scientific community to develop new therapies improve situation. Considering complex microenvironment persistent mechanisms mediated by bacteria, it is crucial an implant with enhanced osseointegration sustained effective infection clearance effects. Here, a...
Abstract A major limitation in the development of effective scaffolds for bone regeneration has been limited vascularization regenerating tissue. Here, we propose a novel calcium phosphate cement (CPC)-based scaffold combining properties mesoporous silica (MS) with recombinant human morphogenic protein-2 (rhBMP-2) to facilitate and osteogenesis. Specifically, custom MS/CPC paste allowed three-dimensional (3D) printing defined macroporous structure optimized silicon (Si) ions release profile...
Synthetic bone scaffolds have potential application in repairing large defects, however, inefficient vascularization after implantation remains the major issue of graft failure. Herein, porous β-tricalcium phosphate (β-TCP) with calcium silicate (CS) were 3D printed, and pre-seeded co-cultured human umbilical cord vein endothelial cells (HUVECs) marrow stromal (hBMSCs) to construct tissue engineering accelerated better formation. Results showed that vitro β-TCP doped 5% CS (5%CS/β-TCP)...
The therapeutic effects of mesenchymal stem cells (MSCs)–material constructs mainly come from the secretion trophic factors MSCs, especially immunomodulatory and angiogenic cytokines. Recent findings indicate significance topographical cues these materials in modulating paracrine functions MSCs. Here, we developed functionalized three-dimensional-printed bioceramic (BC) scaffolds with a mussel-inspired surface coating order to regulate function adipose-derived MSCs (Ad-MSCs). We found that...
INTRODUCTION: Data on the associations between esophageal histological lesions and risk of squamous cell carcinoma (ESCC) in general populations are limited. We aimed to investigate these a large Chinese population inform future ESCC screening guidelines. METHODS: performed endoscopic 21,111 participants aged 40–69 years from 3 high-risk areas China 2005–2009, followed cohort through 2016. Cumulative incidence mortality rates were calculated by baseline diagnosis, hazard ratios ESCC, overall...