Abstract Recently, artificial intelligence research has driven the development of stretchable and flexible electronic systems. Conductive hydrogels are a class soft materials that have emerging applications in wearable implantable biomedical devices. However, current conductive possess fundamental limitations terms their antibacterial performance mechanical mismatch with human tissues, which severely limits biological interfaces. Here, inspired by animal skin, hydrogel is fabricated from...

Abstract Conductive hydrogels as flexible electronic devices, not only have unique attractions but also meet the basic need of mechanical flexibility and intelligent sensing. How to endow anisotropy a wide application temperature range for traditional homogeneous conductive sensors is still challenge. Herein, directional freezing method used prepare anisotropic MXene that are inspired by ordered structures muscles. Due hydrogels, properties electrical conductivity enhanced in specific...

This study demonstrates high contrast and sensitivity by designing a dual-emissive hydrogel particle system, whose two emissions respond to pH temperature strongly independently. It describes the photoluminescence (PL) response of poly(N-isopropylacrylamide) (PNIPAM)-based core/shell nanoparticles with dual emission, which is obtained emulsion polymerization potassium persulfate, consisting thermo- pH-responsive copolymers PNIPAM poly(acrylic acid) (PAA). A red-emission rare-earth complex...

Stem cell-based therapy has drawn attention for enhancing the osseointegration efficiency after joint replacement in rheumatoid arthritis (RA). However, therapeutic efficacy of this approach is threatened by accumulated reactive oxygen species (ROS) and poor supply. Herein, we develop a nanozyme-reinforced hydrogel reshaping hostile RA microenvironment improving prosthetic interface osseointegration. The engineered not only scavenges endogenously over-expressed ROS, but also synergistically...

Abstract Non‐healing wound is a common complication of diabetic patients associated with high morbidity and mortality. Engineered therapeutic hydrogels have enviable advantages in tissue regeneration, however, they are suboptimal for the healing wounds characterized by reactive oxygen species (ROS) accumulation chronic hypoxia. Here, unique biological metabolism‐inspired hydrogel, ameliorating this hostile microenvironment, presented. Consisting natural polymers (hydrazide modified...

The healing of diabetic foot ulcers (DFUs) is a major challenge for clinical treatment because the hyperglycemic and acidic microenvironment in wound area. In this study, self-healing, injectable, pH-responsive hydrogel was synthesized by N-carboxyethyl chitosan (N-chitosan), hyaluronic acid–aldehyde (HA-ALD), adipic acid dihydrazide (ADH) through formation reversible dynamic bonds, acylhydrazone imine bonds. presence bond characterizes property. insulin glargine successfully incorporated...

Abstract Conductive hydrogels have recently gained impressive attention in biological medicine and intelligent electronics. Despite the multifunctions demonstrated by existing conductive hydrogels, it is still a challenge to introduce hydrogel adjust distance between peritumoral organs tumor, reducing radiation damage organs. Here, hydrophobic associating with multiple desirable features fabricated based on diverse supramolecular assembly. The introduction of MXene hydrolyzed keratin (HK)...

Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels are promising systems for DFU-based wound management, their effectiveness is often hindered by the immune response and hostile microenvironment associated with uncontrollable accumulation of reactive oxygen species hypoxia. Here, we develop therapeutic dressing using biomimetic hydrogel system decoration catalase-mimic nanozyme, namely, MnCoO@PDA/CPH. The can be designed match mechanical electrical cues...

A diabetic foot ulcer (DFUs) is a state of prolonged chronic inflammation, which can result in amputation. Different from normal skin wounds, various commercially available dressings have not sufficiently improved the healing DFUs. In this study, novel self-healing hydrogel was prepared by situ crosslinking N-carboxyethyl chitosan ( N-chitosan) and adipic acid dihydrazide (ADH) with hyaluronic acid-aldehyde (HA-ALD), to provide moist inflammatory relief environment promote stem cell...

Diabetic foot ulcers (DFUs) are hard-healing chronic wounds and susceptible to bacterial infection. Conventional hydrogel dressings easily lose water at high temperature or freeze low temperature, making them unsuitable for long-term use in extreme environments. Herein, a temperature-tolerant (−20 60 °C) antibacterial dressing is fabricated by the assembly of polyacrylamide, gelatin, ε-polylysine. Owing water/glycerin (Gly) binary solvent system, resultant (G-PAGL) displayed good heat...

: Osteoporosis is more likely to cause serious complications after joint replacement, mainly due physiological defects of endogenous osteogenic cells and the pathological osteoclast activity. It a feasible solution design prosthetic surface interface that specifically addresses this troublesome situation.

Cobalt-based electrocatalysts for water splitting have attracted extensive research interests. However, the single function, poor performances, and restriction of electrolyte pH value restricted their further development. Here, morphological interfacial engineering cobalt nanoparticles, are performed by incorporation carbon dots (CDs). Typically, nitrogen-doped carbon-encapsulated nanoparticles (N–C@Co NPs) were in situ constructed electrocatalytic overall splitting, exhibiting superior...

3D printed porous titanium alloy implants is an advanced orthopedic material for joint replacement. However, the high risk of aseptic loosening and periprosthetic infection difficult to avoid, declined autophagy osteoporosis-derived bone marrow mesenchymal stem cells (OP-BMSCs) further severely impairs osseointegration under osteoporotic circumstance. It thus becoming urgently significant develop materials with regulation antibacterial bioactivity. In this regard, a novel class...

The analysis of individual biological nanoparticles has significantly advanced our understanding fundamental processes but is also rapidly becoming relevant for molecular diagnostic applications in the emerging field personalized medicine. Both optical and electrical methods detection single biomolecules have been developed, they are generally not used concert suitably integrated form to allow multimodal with high throughput. Here we report on a dual-mode single-nanoparticle sensing device...

Abstract Stem cell transplantation is a promising alternative therapy for rheumatoid arthritis (RA) patients, with the potential to suppress autoimmune inflammation and prevent joint damage. However, widespread application of RA based on stem limited due poor migration, local retention, uncontrolled differentiation cells. Here, inspired by dynamic construction bone matrix, structurally functionally optimized scaffold loading marrow cells (BMSCs) designed aid management. The composite...

With the prevalence of eye diseases, such as inflamed eyes, corneal injury, cataract, glaucoma, and retinal degenerative different clinical strategies have been developed, however, they still suffer from many inevitable drawbacks in practical applications. Functionalized hydrogels emerged attractive materials revolutionary for ophthalmic applications owing to their favorable properties, excellent biocompatibility, near-physiological extracellular matrix environment, injectability, tailorable...

Spinal cord injury (SCI) generally leads to long-term functional deficits and is difficult repair spontaneously. Many biological scaffold materials stem cell treatment strategies have been explored, but very little research focused on the method of combining exogenous neural cells (NSCs) with a biodegradable conductive hydrogel scaffold. Here, NSC loaded (named ICH/NSCs) was assembled by amino-modified gelatin (NH2-Gelatin) aniline tetramer grafted oxidized hyaluronic acid (AT-OHA)....

Fluid hydrogel is proper to be incorporated with rigid porous prosthesis interface, acting as a soft carrier support cells and therapeutic factors, enhance osseointegration. In the previous study, we innovatively utilized self-healing supramolecular 3D cell culture platform incorporate printed titanium alloy scaffold, constructing novel bioactive interface. However, concrete relationship mechanism of stiffness influencing cellular behaviors bone marrow mesenchymal stem (BMSCs) within...

Abstract Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non‐invasiveness. However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells activating immune responses. Here, two US Food Drug Administration‐approved drug ligands (ferricyanide nitroprusside) types metals (copper/iron) selected construct a bimetal‐biligand framework (Cu[PBA‐NO]). Through...