A5100757354- Bone Tissue Engineering Materials
- 3D Shape Modeling and Analysis
- Orthopaedic implants and arthroplasty
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- 3D Printing in Biomedical Research
- Calcium Carbonate Crystallization and Inhibition
- Industrial Vision Systems and Defect Detection
- Nanoplatforms for cancer theranostics
- Dental Implant Techniques and Outcomes
- Robotics and Sensor-Based Localization
- Medical Image Segmentation Techniques
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- 3D Surveying and Cultural Heritage
- Neuropeptides and Animal Physiology
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Advanced Image and Video Retrieval Techniques
- Dental materials and restorations
- Education and Learning Interventions
- MicroRNA in disease regulation
Sun Yat-sen Memorial Hospital
2017-2025
Sun Yat-sen University
2017-2025
Southwest Jiaotong University
2012-2024
Central China Normal University
2021-2024
New York University
2021-2024
Convalife (China)
2024
New York University Abu Dhabi
2022-2024
Guangdong University of Technology
2023
Nantong University
2023
Royal National Orthopaedic Hospital
2022
The resection of malignant osteosarcoma often results in large segmental bone defects, and the residual cells can facilitate recurrence. Consequently, treatment is a major challenge clinical practice. ideal goal for to eliminate it thoroughly, repair resultant defects as well avoid bacterial infections. Herein, we fabricated selenium/strontium/zinc-doped hydroxyapatite (Se/Sr/Zn-HA) powder by hydrothermal method, then employed with polycaprolactone (PCL) ink construct composite scaffolds...
Abstract The transition from androgen-dependent to metastatic castration-resistant prostate cancer (PCa) is a lethal event of uncertain molecular aetiology. Our previous studies demonstrated that L -plastin involved in PCa invasion and metastasis upregulated by androgen oestrogen the hormone-dependent cell line LNCaP. We recently found expression consistently activated even after deprivation, suggesting androgen-independent transcription factors may regulate its expression. Herein, we...
The integration of photothermal therapy (PTT) with gene (GT) in a single nanoscale platform demonstrates great potential cancer therapy. Porous iron oxide nanoagents (PIONs) are widely used as magnetic the drug delivery field and also serve nanoagent for However, therapeutic efficacy PIONs-mediated GT has not been studied. long noncoding RNA (lncRNA) CRYBG3 (LNC CRYBG3), lncRNA induced by heavy ion irradiation lung cells, reported to directly bind globular actin (G-actin) cause degradation...
Abstract Background Bone metastasis is a principal cause of mortality in patients with prostate cancer (PCa). Increasing evidence indicates that high expression stromal interaction molecule 1 (STIM1)-mediated store-operated calcium entry (SOCE) significantly activates the (Ca 2+ ) signaling pathway and involved multiple steps bone PCa. However, regulatory mechanism target therapy STIM1 poorly defined. Methods Liquid chromatography-mass spectrometry analysis was performed to identify...
Particles that modify delivery characteristics are a focus of drug-loading research. Hydroxyapatite particles (HAPs) have excellent biocompatibility, shape controllability, and high adsorption, making them potential candidate for drug-delivery carriers. However, there still some defects in the current methods used to prepare HAPs. In order avoid agglomeration improve properties HAPs, present study provides novel triethylamine (TEA)-capped coprecipitation template method HAPs at room...
Abstract Porous hydroxyapatite (HA) scaffolds are often used as bone repair materials, owing to their good biocompatibility, osteoconductivity and low cost. Vascularization osteoinductivity of porous HA were limited in clinical application, these disadvantages need be improved urgently. We water-in-oil gelation pore former methods prepare spheres a cylindrical container, respectively. The prepared filled container assemble into composite scaffold. By adjusting the solid content slurry (solid...
Lymphatic metastasis, an early stage of the metastasis process, is associated with adverse clinical outcomes in urothelial carcinoma bladder (UCB). However, role inflammation triggering lymphatic remains unclear. We employed RNA-sequencing cohort (n = 50) from Sun Yat-Sen Memorial Hospital (SYMH) to identify most highly upregulated inflammatory gene metastasis. Using immunohistochemistry and immunofluorescence analyses, we validated association identified molecule features prognosis...
Darolutamide, an androgen receptor inhibitor, has been approved by the Food and Drug Administration (FDA) for treatment of prostate cancer (PCa), especially patients with mutations. Owing to unique lipidomic profile PCa effect darolutamide, relationship between darolutamide ferroptosis remains unclear. The present study showed that significantly induces in AR
Abstract Background Preclinical and clinical studies highlight the enhanced anticancer efficacy of combining anti-VEGF/VEGFR drugs with immune checkpoint inhibitors (ICIs). PD-L1/VEGF bispecific antibodies outperform monotherapy or combined PD-L1 anti-VEGF by simultaneously blocking PD-1/PD-L1 pathway VEGF-driven angiogenesis, providing a dual mechanism for superior antitumor activity. Methods We developed CVL006, novel antibody, fusing an anti-PD-L1 VHH domain humanized IgG1 monoclonal...
Abstract Chronic nonbacterial prostatitis (CNP) is challenging to treat due limited options. This study introduces a new approach using natural ferulic acid‐based polymer nanoparticles target CNP. Ferulic acid (FA) polymerized into poly(ferulic acid) and forms (PFA NPs). Folic (Fa) added for targeting, celecoxib (Cel) loaded, creating PFA‐Fa@Cel NPs. These nanoparticles, ≈100 nm in size, have 39% drug encapsulation efficiency, showing good stability, biocompatibility, controlled release,...
Abstract Radiation and microgravity are undoubtedly two major factors in space environment that pose a health threat to astronauts. However, the mechanistic study of their interactive biological effects is lacking. In this study, human lung bronchial epithelial Beas-2B cells were used regulation radiobiological by simulated (using three-dimensional clinostat). It was found together with radiation induced drop survival fraction, proliferation inhibition, apoptosis, DNA double-strand break...
Infrared thermal image can record a large number of fault problems in the power grid, and become most important detection method defects current equipment. At present, methods artificial analysis infrared images equipment have some problems, such as low efficiency error prone, poor real-time performance massive data input effective feedback, difficult association analysis. In past, processing technology was used to automatically analyze image. Because pixel fuzzy boundary image, recognition...
Androgen deprivation therapy has been used as a standard clinical treatment for prostate cancer, but the disease generally progresses to castration-resistant cancer in very short time. Enzalutamide (ENZ) is an emerging second-generation androgen receptor (AR) antagonist of patients with nonmetastatic (CRPC). However, due rapid onset drug resistance, it provides only modest increase survival. Here, we propose convenient and effective delivery strategy, that is, use biocompatible nanoparticle...
Prostate cancer (PCa) is the second most common malignant tumor among males. Traditional treatments for PCa, which include surgery and endocrine therapy, have shown limited success, more effective therapies are needed. Cisplatin (DDP) an approved chemotherapeutic drug that causes DNA damage in cancer, whereas AZD7762, inhibitor of CHK1, can significantly inhibit repair. The therapeutic combination cisplatin response AZD7762 has been considered to be a potential solution resistance adverse...