A5049581911- Carbon and Quantum Dots Applications
- Plant tissue culture and regeneration
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Management of metastatic bone disease
- Ovarian cancer diagnosis and treatment
- Cell death mechanisms and regulation
- Bone Tumor Diagnosis and Treatments
- Flavonoids in Medical Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Musculoskeletal synovial abnormalities and treatments
- Wound Healing and Treatments
- Spinal Fractures and Fixation Techniques
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Nanoplatforms for cancer theranostics
Ningbo Institute of Industrial Technology
2021-2025
Chinese Academy of Sciences
2021-2025
Ningxia Medical University General Hospital
2021-2025
Ningxia Medical University
2021-2025
Weatherford College
2021
Ningbo University
2021
Zhejiang University
2021
Fujian Agriculture and Forestry University
2021
Hubei University of Arts and Science
2018-2020
Xiangyang Central Hospital
2014-2020
Recent studies have demonstrated ubiquitous somatic microsatellite mutations in some cancers of the colon, endometrium, stomach, and pancreas.Our purpose was to characterize frequency nature this replication error (RER) or mutator phenotype sporadic endometrial carcinoma.Formalin-fixed, paraffin-embedded normal tumor tissues from 45 patients with cancer were screened for RER at three loci. To further when these alterations acquired relative clonal expansion, sizes altered microsatellites...
Background:Ovarian epithelial tumors can be divided into subcategories often regarded as different stages of neoplastic transformation. Cystadenomas belong to the least aggressive subgroup and are noninvasive nonmetastatic. Ovarian low malignant potential (LMP) intermediate between cystadenomas carcinomas show markedly reduced invasive metastatic abilities. Invasion metastasis hallmarks carcinomas, which constitute most further subdivided grades.
Abstract The transition from androgen-dependent to metastatic castration-resistant prostate cancer (PCa) is a lethal event of uncertain molecular aetiology. Our previous studies demonstrated that L -plastin involved in PCa invasion and metastasis upregulated by androgen oestrogen the hormone-dependent cell line LNCaP. We recently found expression consistently activated even after deprivation, suggesting androgen-independent transcription factors may regulate its expression. Herein, we...
Journal Article Genetic Disparity Between Morphologically Benign Cysts Contiguous to Ovarian Carcinomas and Solitary Cystadenomas Get access Jianping Zheng, Zheng Department of Pathology, Kenneth Norris Jr. Comprehensive Cancer Center. University Southern California School MedicineLos Angeles, CA Correspondence : Louis Dubeau, M.D., Ph.D., USC/Kenneth Center, 1441 Eastlake Ave., Los Angeles. 90033. Search for other works by this author on: Oxford Academic PubMed Google Scholar William F....
In this study, we cloned and characterized a human gene homologous to the apoptosis-inducing factor (AIF), which is named AIF-like (AIFL). Human AIFL has 598 amino acids, with characteristic Rieske domain pyridine nucleotide-disulfide oxidoreductase (Pyr_redox). shares 35% homology AIF, mainly in Pyr_redox domain. Reverse transcriptase-PCR analysis showed expression of mRNA all tissues tested, i.e. brain, colon, heart, kidney, liver, lung, muscle, ovary, pancreas, placenta, small intestine,...
Osteosarcoma is a primary bone tumor that mainly occurs in children and adolescents. Absent melanoma 2 (AIM2) has been demonstrated to be involved regulating the occurrence development of cancer, exerting oncogenic pro‑cancer effects; however, its role osteosarcoma poorly understood. The present study aimed explore function molecular mechanism AIM2 progression osteosarcoma. In study, expression was predicted using Cancer Cell Line Encyclopedia database examined several cell lines reverse...
Abstract Junctional adhesion molecule-A (JAM-A) belongs to the immunoglobulin superfamily, it predominantly exists at tight junctions of epithelial and endothelial cells. JAM-A is known regulate leukocyte trans-endothelial migration, however, how affects proliferation migration keratinocytes, two essential steps during wound healing, has less been explored. In this study, we showed that was significantly expressed in normal skin epidermis. RNAi-mediated knockdown remarkably promoted...
To evaluate the clinical efficacy of repairing bone defects caused by benign tumors using allograft combined with calcium phosphate powder. A retrospective analysis was conducted on 55 patients (aged 10–61 years, mean 35 ± 13.2) treated at our hospital from June 2020 to December 2022. The in these cases were created after surgical curettage tumor lesions, which included common such as osteochondroma, giant cell bone, and enchondroma. Patients divided into two groups based graft materials: a...
Abstract Osteosarcoma (OS) is a prevalent primary malignant bone tumor that lacks effective therapeutic interventions. Artesunate (ART) has been proved to have remarkable treatment effects on severe malaria and anti‐tumor properties. This study aimed investigate the anti‐OS underlying mechanisms of ART. The potential ART‐mediated activity were analyzed by using RNA sequencing, iron accumulation, lipid peroxidation, western blotting, small interfering (siRNA) transfection. In vivo, xenograft...
Scutellaria barbata (SB) has been used in Chinese medicine to treat various cancers. This study investigated the effects of SB on prostate cancer prevention. Male TRansgenic Adenocarcinoma Mouse Prostate (TRAMP) mice at 9 weeks were randomly divided into four groups and given daily oral feedings 8, 16, or 32 mg sterilized water. In control group, palpable tumors initially appeared 19 age present all by weeks. respective treatment groups, tumor development was delayed 2, 4, 7 22, 30, 38% free...
Objective This study aims to investigate the treatment strategies for lumbar brucellar spondylitis by comparing outcomes of pure pharmacological with diseased intervertebral fixation fusion, or without lesion clearance. Methods A total 157 patients were categorized into three groups: Group (52 cases) received treatment, B (53 underwent posterior vertebral and C (or anterior) clearance followed fusion. Clinical data analyzed, efficacy methods was evaluated. Results The surgical groups showed...
Theaflavins (TFs) are the main bioactive polyphenols in tea and contribute to protection against oxidative stress. Excessive reactive oxygen species (ROS) accumulation can lead disruption of cartilage homeostasis. The present study examined potential effects TFs on H2O2‑induced degeneration vitro. Cell Counting kit (CCK‑8) was used determine cell viability, flow cytometric analysis detect ROS, apoptosis DNA damage. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR)...
The L-plastin gene is involved in the invasion and metastasis of prostate cancer. However, molecular mechanisms underlying transcription are unclear. We hypothesize that occurrence polymorphic genetic variations promoter might affect an individual's susceptibility to In this study, we identified a single nucleotide polymorphism (SNP) at position −1,687 by genotype sequencing. SNP showed different transcriptional activity luciferase assay vitro. TRANSFAC software was applied predict multiple...
Background. Spinal tuberculosis (STB) often leads to irreversible neurological injury, resulting in serious social and economic problems. With the emergence of drug resistance, management becomes even more challenging, given treatment courses are generally longer for skeletal than pulmonary (PTB). The development validation nonsputum biomarkers diagnosis tailoring duration enable personalized evidence-based such diseases improve outcomes is being called globally. Studies have demonstrated...