A5043558635- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Osteoarthritis Treatment and Mechanisms
- Medical Imaging and Analysis
- Fungal and yeast genetics research
- Electrospun Nanofibers in Biomedical Applications
- Anatomy and Medical Technology
- Pluripotent Stem Cells Research
- biodegradable polymer synthesis and properties
- Microbial Metabolic Engineering and Bioproduction
- Cancer Cells and Metastasis
- thermodynamics and calorimetric analyses
- Orthopedic Surgery and Rehabilitation
- Advanced Graph Neural Networks
- Brain Tumor Detection and Classification
- Macrophage Migration Inhibitory Factor
- Mycotoxins in Agriculture and Food
- Biomedical Ethics and Regulation
- Shoulder and Clavicle Injuries
- Facial Nerve Paralysis Treatment and Research
- Text and Document Classification Technologies
- Extracellular vesicles in disease
- Biofuel production and bioconversion
Xi’an Jiaotong-Liverpool University
2025
Fudan University
2021-2024
Taishan University
2023
Shandong University
2023
Donghua University
2023
Fifth Hospital In Wuhan
2021
Wuhan University
2021
Shanghai Ninth People's Hospital
2017-2020
Shanghai Jiao Tong University
2017-2020
The challenges in bone tumor therapy are how to repair the large defects induced by surgery and kill all possible residual cells. Compared cancellous defect regeneration, cortical regeneration has a higher demand for substitute materials. To best of our knowledge, there currently few bifunctional biomaterials with an ultra-high strength both regeneration. Here, we designed Fe-CaSiO3 composite scaffolds (30CS) via 3D printing technique. First, 30CS possessed high compressive that provided...
In the present study, we fabricated a biocomposite scaffold composed of carboxymethyl chitosan (CMC), gelatin and LAPONITE® (Lap) nanoparticles<italic>via</italic>freeze-drying investigated its potential use in bone tissue engineering.
The therapeutic effects of mesenchymal stem cells (MSCs)–material constructs mainly come from the secretion trophic factors MSCs, especially immunomodulatory and angiogenic cytokines. Recent findings indicate significance topographical cues these materials in modulating paracrine functions MSCs. Here, we developed functionalized three-dimensional-printed bioceramic (BC) scaffolds with a mussel-inspired surface coating order to regulate function adipose-derived MSCs (Ad-MSCs). We found that...
Sr incorporated scaffolds promote the polarization of neutrophils to N2 phenotype through STAT3 activation and inhibition NF-κB signal pathway, which induced M2 macrophage differentiation, inflammation resolution angiogenesis.
Abstract Tissue engineering is theoretically thought to be a promising method for the reconstruction of biological joints, and thus, offers potential treatment alternative advanced osteoarthritis. However, date, no significant progress made in regeneration large joints. In current study, biomimetic scaffold rabbit humeral head consisting heterogeneous porous architecture, various bioinks, different hard supporting materials cartilage bone regions designed fabricated one step using 3D...
The development of Machine Learning (ML) and Deep (DL) has brought revolutionary changes to medical image analysis provided a new solution for diagnosing treating all categories disease. This paper is going review the applications ML DL techniques in field such as X-rays, CT scans, MRI, DEXA, particular, their role diagnosis orthopedic diseases. With progress AIs processing power universality open-source platforms, MLs algorithms have developed rapidly, it significantly boosted...
Objective To evaluate the feasibility of arthroplasty with varisized three‐dimensional(3D) printing lunate prosthesis for treatment advanced Kienböck's disease (KD). Methods From 2016 November to 2018 September, a retrospective study was performed patients KD in our hospital. Five (two males, three females) were included this study. The mean age at time surgery 51.6 years (range, 37–64 years). Varisized identical live model ratio 1:0.85, 1:1, and 1:1.1 fabricated by 3D printing. All (one...
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Ti6Al4V printing particles have been recently used for fabricating orthopedic implants. Removing these completely from fabricated implants is challenging. Furthermore, recycled are commonly in fabrication without additional analysis. wear derived known to induce inflammatory responses and osteolysis. However, the biosafety of remains unknown. Here, we investigated proinflammatory osteolysis-inducing effects original vitro vivo. Our results indicated that although less serious were induced...
Graph Neural Networks (GNNs) have gained widespread application in the field of recommendation systems due to their flexibility and effectiveness modeling graph-structured data. GNN enable collection high-dimensional information from user-item interaction graphs through multiple layers convolution propagation, facilitating a holistic users items. However, GNN-based models face challenge over-smoothing sparsity, which hinders ability learn optimal node representations. To address this issue,...
Trichothecenes are highly toxic mycotoxins produced by Fusarium fungi, while TRI101/201 family enzymes play a crucial role in detoxification through acetylation. Studies on the substrate specificity and catalytic kinetics of have revealed distinct kinetic characteristics, with significant differences observed efficiency toward deoxynivalenol, for T-2 toxin remains relatively consistent. In this study, we used structural bioinformatics analysis molecular dynamics simulation workflow to...
Objective To establish a finite element model of rotator cuff which can be used to simulate the injury and evaluate biomechanical effects surgery. Methods The DICOM CT images right shoulder Chinese healthy volunteer were models scapula, humerus clavicle. The structures separated modeled based on MRI anatomical knowledge. After was introduced into analysis software Abaqus 6.12, positions simulated when at 30° internal rotation, external abduction, adduction, flexion...
Objective To investigate the feasibility of an accuracy evaluation method for 3D reconstructed bone model based on reconstruction software Arigin3D Pro. Methods Pig femurs were used as solid models which scanned by CT and MRI respectively. The scan data imported into Pro 3 operators with different experience (≤1 year, 2 to years, ≥4 respectively). Each operator times in each measured diameter femoral head, length femur width knee joint at distal end respectively using Geomagic Wrap....