A5019626641- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Graphene and Nanomaterials Applications
- Bone and Joint Diseases
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Knee injuries and reconstruction techniques
- Biomarkers in Disease Mechanisms
- Axon Guidance and Neuronal Signaling
- Photodynamic Therapy Research Studies
- Advanced Thermoelectric Materials and Devices
- Nonlinear Optical Materials Research
- Thermal properties of materials
- Signaling Pathways in Disease
- Nonlinear Optical Materials Studies
- Extracellular vesicles in disease
- Reconstructive Surgery and Microvascular Techniques
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2014-2025
Queensland University of Technology
2024
Southern University of Science and Technology
2022
University School
2020
Shanghai Normal University
2020
Ruijin Hospital
2017
Texas Christian University
2008
Reactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, greatly limited the hypoxia microenvironment (TME) and antioxidant defense. Amplification of oxidative stress has been successfully employed for therapy, but interactions between cells other factors TME usually lead to inadequate treatments. To tackle this issue, we develop a pH/redox dual-responsive nanomedicine based on remodeling cancer-associated fibroblasts...
Revision THA is particularly challenging in hips with severe acetabular bone loss. When the extent or geometry of loss precludes more-straightforward techniques such as jumbo hemispheric cementless shells, reconstruction morselized allograft protected by a custom cage may offer an alternative, but, to our knowledge, few series have reported on results this approach.For patients (Paprosky IIIB) defects, we asked: do individualized cages result (1) improved Harris hip scores; (2) restoration...
Abstract Although great progress has been made in engineered bone tissues, delayed or ineffective regeneration remains an issue due to the lack of neural network reconstruction their design. Therefore, tissue construct that mimics ossification center microenvironment promote innervation is proposed. Based on this, NGF@Lap constructs are constructed through bioprinting technology, which can release nerve growth factor (NGF) for a long time and simulate center's with high expression NGF. In...
Rationale: Osteoporotic patients suffer symptoms of excessive osteoclastogenesis and impaired osteogenesis, resulting in a great challenge to treat osteoporosis-related bone defects. Based on the positive effect rare earth elements metabolism regeneration, we try prove hypothesis that La3+ dopants lanthanum-substituted MgAl layered double hydroxide (La-LDH) nanohybrid scaffolds simultaneously activate osteogenesis inhibit osteoclastogenesis. Methods: A freeze-drying technology was employed...
Hypoxia is a characteristic of solid tumors that can lead to tumor angiogenesis and early metastasis, addressing hypoxia presents tremendous challenges. In this work, nanomedicine based on oxygen-absorbing perfluorotributylamine (PFA) the bioreductive prodrug tirapazamine (TPZ) was prepared by using polydopamine (PDA)-coated UiO-66 metal organic framework (MOF) as drug carrier.The results showed TPZ/PFA@UiO-66@PDA nanoparticles significantly enhanced hypoxia, induced cell apoptosis in vitro...
Abstract Background Breast cancer bone metastasis has become one of the most common complications; however, it may cause recurrence and nonunion, as well local defects. Methods Herein, In vitro, we verified effect bioscaffold materials on cell proliferation apoptosis through a CCK8 trial, staining live/dead cells, flow cytometry. We used immunofluorescence technology cytometry to verify whether regulate macrophage polarization, ALP staining, alizarin red PCR material promotes regeneration....
Abstract The integration of three-dimensional (3D) bioprinted scaffold’s structure and function for critical-size bone defect repair is immense significance. Inspired by the basic component innate cortical tissue—osteons, many studies focus on biomimetic strategy. However, complexity hierarchical microchannels in osteon, requirement mechanical strength bone, biological angiogenesis osteogenesis remain challenges fabrication osteon-mimetic scaffolds. Therefore, we successfully built mimetic...
Abstract Tissue engineering is theoretically thought to be a promising method for the reconstruction of biological joints, and thus, offers potential treatment alternative advanced osteoarthritis. However, date, no significant progress made in regeneration large joints. In current study, biomimetic scaffold rabbit humeral head consisting heterogeneous porous architecture, various bioinks, different hard supporting materials cartilage bone regions designed fabricated one step using 3D...
In developmental dysplasia of the hip (DDH), a bone defect is often observed superior to acetabulum after reconstruction at level true during total replacement (THR). However, essential amount uncemented acetabular component coverage required for satisfactory outcome remains controversial. The purpose this study was assess stability and function components with lack > 30% (31% 50%). A 760 DDH patients underwent THR floor. Lack above occurred in 56 patients. Intra-operatively, autogenous...
Abstract Aseptic loosening caused by wear particles is a common complication after total hip arthroplasty. We investigated the effect of quercetin on particle‐mediated macrophage polarization, inflammatory response and osteolysis. In vitro, we verified that Ti promoted differentiation RAW264.7 cells into M1 macrophages through p‐38α/β signalling pathway using flow cytometry, immunofluorescence assay small interfering RNA. used enzyme‐linked immunosorbent assays to confirm protein expression...
The aim of this study was to assess the effect naringenin on osteoclastogenesis and titanium particle-induced osteolysis. Osteolysis from wear-induced particles aseptic loosening are most frequent late complications total joint arthroplasty leading revision prosthesis. during is likely due increased bone resorption by osteoclasts. Through in vitro studies, we demonstrated that naringenin, a naturally occurring flavanone grapefruit tomatoes, exerts potent inhibitory effects ligand receptor...
Background Chronic pain is the most prominent and disabling symptom of osteoarthritis (OA). Clinical data suggest that subchondral bone lesions contribute to occurrence joint pain. The present study investigated effect inhibition on Methods Osteoarthritic was induced by an injection monosodium iodoacetate (MIA) into rat knee joint. Zoledronic acid (ZOL), a third generation bisphosphonate, used inhibit lesions. Joint histomorphology evaluated using X-ray micro computed tomography scanning...
To evaluate accuracy of an innovative "Skywalker" system, a newly designed, robot-assisted operation system for orthopaedics via clinical trial at knee joint. We conducted prospective analysis the data 31 patients who underwent total arthroplasty assisted by robot (Microport, Suzhou, China) from June 2020 to January 2021. Five male and 26 female aged 69.68 ± 6.11 years (range: 57-79 years) were diagnosed with osteoarthritis indicated surgery. The surgical robotic was adopted make...
Cell senescence or apoptosis contributes to self-failure and functional loss in specialized cells, leading incapacity of the body repair specific damages. Senescent bone marrow mesenchymal stem cells (BMSCs) lose their proliferative abilities secrete senescence-associated secretory phenotype (SASP), hindering participation defect repair. Hence, effective suppression cell is crucial restore self-repair capacity treat defects. Since Janus kinase/signal transducer activator transcription...
Abstract Due to its inherent ductility, Ag 2 S shows promise as a flexible thermoelectric material for harnessing waste heat from diverse sources. However, performance remains subpar, and existing enhancement strategies often compromise ductility. In this study, novel Sn‐doping‐induced biphasic structuring approach is introduced synergistically control electron phonon transport. Specifically, Sn‐doping incorporated into 0.7 Se 0.3 form composition comprising (Ag, Sn) the primary phase...