A5103245890- Reproductive Biology and Fertility
- Mitochondrial Function and Pathology
- Reproductive System and Pregnancy
- Hydrology and Watershed Management Studies
- Sperm and Testicular Function
- Bone Metabolism and Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Flood Risk Assessment and Management
- Hepatitis B Virus Studies
- Epilepsy research and treatment
- Aortic aneurysm repair treatments
- Pediatric health and respiratory diseases
- Lipid metabolism and disorders
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Hepatitis Viruses Studies and Epidemiology
- Genetic factors in colorectal cancer
- Pain Mechanisms and Treatments
- Bone health and osteoporosis research
- Ubiquitin and proteasome pathways
- Soil erosion and sediment transport
- Genomic variations and chromosomal abnormalities
- Hepatitis C virus research
- Neonatal Health and Biochemistry
- Assisted Reproductive Technology and Twin Pregnancy
Nanjing Drum Tower Hospital
2009-2024
Weatherford College
2024
Tsinghua University
2024
Nanjing University
2006-2024
Zhejiang University
2024
Nanjing Medical University
2020-2023
Second Affiliated Hospital of Nanjing Medical University
2023
Wuxi People's Hospital
2023
Institut de Médecine de la Reproduction
2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019
To evaluate the usefulness of a fasting plasma glucose (FPG) at 24-28 weeks' gestation to screen for gestational diabetes mellitus (GDM).The medical records and results 75-g 2-h oral tolerance test (OGTT) 24,854 pregnant women without known pre-GDM attending prenatal clinics in 15 hospitals China were examined.FPG cutoff value 5.1 mmol/L identified 3,149 (12.1%) with GDM. FPG 4.4 ruled out GDM 15,369 (38.2%) women. With use this point, 12.2% patients mild will be missed. The positive...
Oogenesis is a fundamental process of human reproduction, and mitochondria play crucial roles in oocyte competence. Mitochondrial ATP-dependent Lon protease 1 (LONP1) functions as critical protein maintaining mitochondrial cellular homeostasis somatic cells. However, the essential role LONP1 mammalian oogenesis far from elucidated.Using conditional Lonp1-knockout mice, RNA sequencing (RNA-seq) coimmunoprecipitation/liquid chromatography-mass spectrometry (Co-IP/LC-MS) technology, we analysed...
儿童家族性腺瘤性息肉病（FAP）是一种常染色体显性遗传病，主要由腺瘤性息肉病（APC）基因突变引起，多数患儿有家族史。FAP患儿的结直肠中常出现成百上千个腺瘤，发展为腺癌的风险较高。内镜检查和基因检测有利于早期诊断和干预。FAP复发率高且无有效根治方法。现就儿童FAP的诊断和治疗进行综述。.
<title>Abstract</title> Declined oocyte quality is the major contributor to female subfertility in aged mammals. Currently, there are no effective interventions ameliorate quality. We found that oocytes from mice exhibited lower levels of mevalonate (MVA) pathway metabolites, including farnesyl pyrophosphate (FPP) and geranylgeranyl (GGPP) reduced cortical F-actin. further demonstrated MVA supplementation improved FPP level, F-actin oocytes. Mechanistically, we induced granulosa cells...
The spatial variability of both meteorological and geographic features has a great influence on rainfall runoff process. When making flood forecasting, the this should be considered. In paper, distributed hydrological modeling technique was adopted to simulate discharge with consideration using DEMs remotely sensed data. our approach, grid based digital elevation data used for presentation watershed discretization deriving flow path system parameters. infiltration excess each hillslope cell...
Background: Oogenesis is a fundamental process of human reproduction, and mitochondria play crucial roles in oocyte competence. Mitochondrial ATP-dependent Lon protease 1 (Lonp1) functions as critical protein maintaining mitochondrial cellular homeostasis somatic cells. However, the essential role Lonp1 mammalian oogenesis far from elucidated.Methods: By using conditional knockout mouse, RNA-seq Co-IP/LC-MS technology, we analysed oogenesis.Findings: Conditional mouse oocytes both primordial...
Abstract Background: To investigate at what extent breastfeeding and vaginal delivery can increase mother-to-child transmission of cytomegalovirus (CMV) to observe the clinical outcomes postnatal CMV infection in infants. Methods: In this secondary study prospectively collected data serum samples, April 2012 through March 2015, 380 pregnant women with IgG positive/CMV IgM negative their 384 infants (4 twin pairs) gestational age ≥32 weeks were included. measured enzyme-linked immunosorbent...
Background: Passive-active immunoprophylaxis with hepatitis B immunoglobulin (HBIG) and vaccine is recommended to prevent mother-to-child transmission (MTCT) of virus (HBV). China has taken a policy provide charge-free HBIG for infants HBV-infected mothers since July 2011. We analyzed HBV infection rate in children born before 2011 real-life practice.Methods: Totally 5149 5004 mothers, 1160 3989 2011, across Jiangsu province, China, were followed up markers at 0*6-8 years age from 2009 2018....
Abstract Embryo adhesion is a very important step in the embryo implantation process. Homeobox A10 (HOXA10), key transcriptional factor of endometrial receptivity, indispensable for adhesion. However, how to control activation status HOXA10 remains elusive. Here, we found that Mitogen-activated protein kinase 4 (MEKK4) was associated with and directly phosphorylated at threonine 362. This MEKK4-mediated phosphorylation enhanced HOXA10-mediated responses between epithelium. Specific deletion...