A5100354763- Luminescence and Fluorescent Materials
- Advanced Fluorescence Microscopy Techniques
- Photochromic and Fluorescence Chemistry
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- Click Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Corneal surgery and disorders
- Advanced Electron Microscopy Techniques and Applications
- Supramolecular Chemistry and Complexes
- Glaucoma and retinal disorders
- Cell Image Analysis Techniques
- Photoreceptor and optogenetics research
- Ocular Infections and Treatments
- Advanced Biosensing Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Organic Light-Emitting Diodes Research
- Near-Field Optical Microscopy
- Polydiacetylene-based materials and applications
- bioluminescence and chemiluminescence research
- Optical Imaging and Spectroscopy Techniques
- Conducting polymers and applications
- Ocular Diseases and Behçet’s Syndrome
North Carolina State University
2019-2025
Beijing Tongren Hospital
2021-2025
Capital Medical University
2012-2025
Xuzhou No.1 People's Hospital
2025
Xuzhou Medical College
2022-2025
Hubei University of Science and Technology
2025
Beijing Institute of Petrochemical Technology
2025
Beijing Friendship Hospital
2025
Applied Photonics (United Kingdom)
2025
University of North Carolina at Chapel Hill
2025
This article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers densely packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly polymer-tethered SPIONs and free poly(styrene)-b-poly(acrylic acid) (PS-b-PAA). The membrane thickness MVs could be well controlled from 9.8 to 93.2 nm by varying weight ratio PS-b-PAA SPIONs. increase was accompanied transition monolayer MVs, double-layered multilayered (MuMVs). can...
Significance The work described represents a strategy in the design and development of theranostic pure nanodrugs for combating drug-resistant bacteria. significance this includes: ( i ) modular synthetic preparation ciprofloxacin derivatives high yields one step at room temperature without any catalysts; ii stable nanoaggregates, prepared following principle aggregation-induced emission, successfully used as fluorescent organic dots to image bacteria; iii formulation that showed...
Abstract Long persistent luminescence (LPL) materials of SrAl 2 O 4 doped with Eu 2+ or Dy 3+ can maintain emission over hours after ceasing the excitation but suffer from insolubility, high cost, and harsh preparation. Recently, organic LPL guest‐host exciplex systems has been demonstrated via an intermediate charge‐separated state flexible design poor air‐stability. Here, we synthesized a nontoxic two‐dimensional organic–inorganic metal hybrid halides (OIMHs), called PBA [ZnX ] X=Br Cl...
In China many respiratory pathogens stayed low activities amid the COVID-19 pandemic due to strict measures and controls. We here aimed study epidemiological clinical characteristics of pediatric inpatients with Mycoplasma pneumoniae pneumonia (MPP) after mandatory restrictions were lifted, in comparison those before pandemic. included 4,296 patients MPP, hospitalized by two medical centers Jiangsu Province, China, from January 2015 March 2024. Patients divided into pre-COVID (n = 1,662)...
The photoinduced disconnection of an oxazine heterocycle from a borondipyrromethene (BODIPY) chromophore activates bright far-red fluorescence. high brightness the product and lack autofluorescence in this spectral region allow its detection at single-molecule level within organelles live cells. Indeed, these photoactivatable fluorophores localize lysosomal compartments remain covalently immobilized organelles. suppression diffusion allows reiterative reconstruction subdiffraction images...
Self-assembling nanoparticles of amphiphilic polymers can transport hydrophobic molecules across hydrophilic media and, as a result, be valuable delivery vehicles for diversity biomedical applications. Strategies to monitor their dynamics noninvasively and in real time are, therefore, essential investigate translocation within soft matrices possibly, rationalize the mechanisms responsible diffusion biological media. In this context, we designed molecular guests with photoactivatable...
Abstract Organic fluorescence scintillators, owing to the ultrafast response time, versatile chemical structures, low processing temperature, and cost, are considered as one of promising materials for medical diagnostics, radiation detection, X‐ray astronomy. However, radioluminescence (RL) intensity sensitivity hinder their practical applications. In this work, a highly efficient organic fluorescent scintillator, 4,4′‐bis(9‐carbazolyl)biphenyl (CBP), is presented, exhibiting high RL...
A three-dimensional hyperbranched polymer (<bold>3D-HP</bold>) with σ–π conjugated <bold>PDMPS</bold> (poly(dichloromethylphenylsilane)s) units covalently bonded to a polyhedral oligosilsesquioxane (POSS) scaffold was prepared by one-step “thiol–ene click chemistry” reaction.
We developed transmission diffraction grating-based spectroscopic single-molecule localization microscopy (sSMLM) to collect the spatial and spectral information of blinking events concurrently. characterized heterogeneities multiple far-red emitting dyes in a high-throughput manner using sSMLM. also investigated influence dispersion on identification performance fluorophores with large overlapping. The careful tuning sSMLM permitted simultaneous three-color super-resolution imaging fixed...
Abstract Spectroscopic single-molecule localization microscopy (sSMLM) was used to achieve simultaneous imaging and spectral analysis of single molecules for the first time. Current sSMLM fundamentally suffers from a reduced photon budget because photons individual stochastic emissions are divided into spatial channels. Therefore, both only use portion total photons, leading precisions in To improve precisions, we present symmetrically dispersed sSMLM, or SDsSMLM, fully utilize all SDsSMLM...
Abstract Dynamic materials undergoing adaptive solid‐state transitions are attractive for soft mechanics and information technology. Here, we report a novel porous framework system based on macrocyclic trimers assembled from open‐shell tetraarylethylene building blocks with aryldicyanomethyl radicals as coupling linkers. Under mechanical, thermal, or chemical stimuli, the showed adaptability by activating conformational dynamics radical‐based transformations, thus displaying macroscopic...
A new type of highly sensitive low-cost sensor towards nitro-compounds based on PEO/MePyCz composite nanofibers is reported. The nanomaterials may also be applied in nano-optoelectronics devices, light-emitting diodes or biological sensors.
The identification of operating principles to activate fluorescence under the influence external stimulations is essential enable implementation imaging strategies requiring spatiotemporal control emission. In this context, our laboratories designed mechanisms switch with either light or pH based on unique photochemical and photophysical properties photoresponsive halochromic oxazines respectively. These heterocycles can be connected covalently fluorescent chromophores opened impose a...
Compounds <bold>1–4</bold> were synthesized, and the optical properties mechanisms investigated. Compound <bold>4</bold> was applied to cell imaging.
A photochemical strategy to encode fluorescence signals in vivo with spatial control was designed around the unique properties of a photoactivatable borondipyrromethene (BODIPY). The photoinduced disconnection two oxazines, flanking single BODIPY, consecutive steps produces mixture three emissive molecules resolved inside polymer beads. relative amounts and emission intensities fluorophores can be regulated precisely each bead by adjusting dose activating photons mark individual particles...
Spectroscopic single-molecule localization microscopy (sSMLM) captures the full emission spectra of individual molecules while simultaneously localizing their spatial locations at a precision greatly exceeding optical diffraction limit. To achieve this, sSMLM uses dispersive component to separate emitted photons into dedicated and spectral imaging channels for simultaneous acquisition. While adding cylindrical lens in channel enabled three-dimensional (3D) sSMLM, inherent astigmatism leads...
Spectroscopic single-molecule localization microscopy (sSMLM) simultaneously provides spatial and spectral information of individual single-molecules emission, offering multicolor super-resolution imaging multiple molecules in a single sample with the nanoscopic resolution. However, this technique is limited by requirements acquiring large number frames to reconstruct image. In addition, sSMLM suffers from cross-talk while using dyes relatively broad bands that produce cross-color...