A5102893270- Bone health and osteoporosis research
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Bone Metabolism and Diseases
- Inflammatory mediators and NSAID effects
- Vitamin D Research Studies
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Cell Adhesion Molecules Research
- Hip and Femur Fractures
- Protease and Inhibitor Mechanisms
- Knee injuries and reconstruction techniques
- Radiopharmaceutical Chemistry and Applications
- Bone and Dental Protein Studies
- Estrogen and related hormone effects
- Peptidase Inhibition and Analysis
- Nutrition and Health in Aging
- Connective tissue disorders research
- Bone fractures and treatments
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Medical Imaging and Pathology Studies
- Vitamin K Research Studies
- Multiple Myeloma Research and Treatments
Inserm
2012-2024
Hôpital Edouard Herriot
2002-2024
Université Claude Bernard Lyon 1
2005-2023
Pathophysiology, Diagnosis and Treatment of Bone Diseases
2012-2023
Lyon College
2022
Cisbio (France)
2009-2015
Hospices Civils de Lyon
2011
Institut National de Recherche en Santé Publique
2009
Structural and Molecular Basis of Infectious Systems
2009
Leiden University Medical Center
2008
Abstract Increased bone turnover has been suggested as a potential risk factor for osteoporotic fractures. We investigated this hypothesis in prospective cohort study performed on 7598 healthy women more than 75 years of age. One hundred and twenty-six (mean 82.5) who sustained hip fracture during mean 22-month follow-up were age-matched with three controls did not fracture. Baseline samples collected prior to the measurement two markers formation urinary resorption: type I collagen...
Abstract Changes of bone turnover with aging are responsible for loss and play a major role in osteoporosis. Although an increase has been documented at the time menopause, subsequent abnormalities resorption formation their potential determining mass elderly have not investigated. To address this issue, we measured battery new sensitive specific markers population-based study 653 healthy women analyzed cross-sectionally, including 432 postmenopausal from 1 to 40 years, data were correlated...
Abstract The mechanisms leading to increased bone loss and skeletal fragility in women with postmenopausal osteoporosis are still poorly understood. Increased resorption, low serum estradiol high sex-hormone-binding globulin (SHBG) recently have been reported as predictors of vertebral hip fractures elderly women. In a cohort healthy untreated younger aged 50–89 years (mean, 64 years), we compared baseline levels markers endogenous hormones 55 who subsequently had fracture (20 35 peripheral...
To evaluate the clinical utility of recently developed biochemical markers bone turnover to monitor response osteoporotic patients antiresorptive therapy, we compared results three advanced assays for resorption and four formation high pressure liquid chromatography (HPLC)-fluorometric urinary pyridinoline deoxypyridinoline. These were also used resolve uncertainties concerning rate in late postmenopausal (late-PMP) women. The 85 women (mean +/- SD age, 63 6 yr) with low mass all more than 5...
Abstract Changes in the level of biochemical markers bone resorption with risedronate treatment for osteoporosis were examined as a surrogate decrease fracture risk. Greater decreases associated greater vertebral (and nonvertebral) fractures. Antifracture efficacy antiresorptive therapies is only partially explained by increases mineral density. Early may also play role. We tested this hypothesis measuring two markers, C-telopeptide type I collagen (CTX) and N-telopeptide (NTX), osteoporotic...
<h3>OBJECTIVE</h3> To analyse the relations between urinary levels of type II collagen C-telopeptide (CTX-II) and glucosyl-galactosyl pyridinoline (Glc-Gal-PYD)—two newly developed biochemical markers synovial tissue destruction respectively—disease activity severity joint in patients with knee osteoarthritis (OA). The clinical performance these two new was compared that a panel other established connective metabolism. <h3>METHODS</h3> following were measured group 67 OA (mean age 64 years,...
Bone resorption may generate collagen fragments such as ICTP and CTX, which can be quantified in serum and/or urine by using specific immunoassays, are used clinical markers. However, the relative abundance of CTX varies according to type bone pathology, suggesting that these two generated through distinct collagenolytic pathways. In this study, we analyzed release from proteinases reported play a role solubilization matrix. Cathepsin K released large amounts but did not allow detectable...
Abstract We used data from the Fracture Intervention Trial to assess relationship change in bone turnover after 1 year of alendronate or placebo treatment and subsequent hip, non-spine, spine fracture risk among 6186 postmenopausal women. In group (n = 3105), greater reductions one more biochemical marker were associated with a lower fracture. Introduction: There are few on between short-term markers non-spine bisphosphonate-treated women, clinical use such measurements is unknown. Materials...
Increased levels of circulating undercarboxylated osteocalcin (ucOC), measured indirectly with the hydroxyapatite (HAP) binding assay, have been shown to predict hip fracture risk in a small group elderly institutionalized women. The aim this study was confirm these findings prospective cohort (EPIDOS study) 7598 healthy, independently living women over 75 yr age. One hundred and four who sustained during 22-month follow-up period were age matched 255 controls did not fracture. Baseline...
The hallmark of osteoarthritis (OA) is the loss articular cartilage. This arises from an imbalance between cartilage synthesis and degradation over a variable period time. aims this study were to investigate rates these processes in patients with knee OA using two new molecular markers whether combined use could predict progression joint damage evaluated by both radiography arthroscopy joints during 1 year.Seventy-five medial (51 women, 24 men; mean +/- SD age 63 8 years, disease duration...
Abstract About one-half of women with incident fractures have BMD above the WHO diagnostic threshold osteoporosis. In OFELY study, low BMD, increased markers bone turnover, and prior fracture could be used to identify, within osteopenic women, those at high risk fracture. Introduction: Recent data suggest that about World Health Organization (WHO) osteoporosis (T score ≤ −2.5). We aimed Materials Methods: 671 postmenopausal (mean age: 62 years) belonging Os des Femmes de Lyon (OFELY)...
Abstract Objective Bisphosphonates have slowed the progression of osteoarthritis (OA) in animal models and decreased pain states high bone turnover. The Knee OA Structural Arthritis (KOSTAR) study, which is largest study to date investigating a potential structure‐modifying drug, tested efficacy risedronate providing symptom relief slowing disease patients with knee OA. Methods group comprised 2,483 medial compartment 2–4 mm joint space width (JSW), as determined using fluoroscopically...
Type 2 diabetes is associated with higher fracture risk at a given bone mineral density. Advanced glycation endproducts (AGEs) accumulate in collagen age and may weaken bone.The aim was to determine whether urine pentosidine, an AGE, fractures older adults without diabetes.We performed observational cohort study.We used data from the Health, Aging Body Composition prospective study of white black, well-functioning men women ages 70-79 yr.Participants (n = 501) 427) were matched on gender,...
We measured serum bone alkaline phosphatase (B-ALP) with a new immunoradiometric assay (IRMA) in large sample of healthy controls comprising 173 women and 180 men, 20-88 yr age, patients metabolic disease. Using samples from liver disease Paget's elevated total (T-ALP) as source of, respectively, isoenzymes, we determined cross-reactivity the IRMA 16% that was confirmed by electrophoresis circulating isoenzymes. The linear for serial dilutions, recovery ranged 89-110%, intra- interassay...
It was recently demonstrated that calcium and vitamin D supplements were capable of decreasing the incidence hip fractures in institutionalized elderly subjects through a reduction senile secondary hyperparathyroidism. As there are no appropriate data to recommend such supplement living at home, aim this study determine hyperparathyroidism old French women from general community, its relation status, contribution bone turnover. Four hundred forty women, aged 75-90 yr, randomly selected...
Abstract We measured the bone mineral density (BMD) at various skeletal sites (total body, hip, anteroposterior [AP] and lateral [lat] spine, forearm) in a large population-based cohort of women aged 31–89 years (the OFELY cohort), results were analyzed according to age postmenopausal years. A significant apparent loss was found before menopause cancellous bone, i.e., lat spine Ward's triangle (−10%; p &lt; 0.05–0.001). Cross-sectional analysis indicated that, after menopause,...
For patients with bone metastases, high N-telopeptide of type I collagen (NTX) levels correlate increased risks skeletal-related events and death. However, the relation between NTX decreases clinical benefits is unclear.Correlations normalization during treatment outcome were retrospectively analyzed in 3 large, phase trials. Urinary measured at baseline Month metastases from breast cancer (BC; n = 578), hormone-refractory prostate (HRPC; 472), or nonsmall-cell lung other solid tumors...