A5100684597- Gout, Hyperuricemia, Uric Acid
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Alcohol Consumption and Health Effects
- Inflammasome and immune disorders
- Diet, Metabolism, and Disease
- Ferroptosis and cancer prognosis
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Healthcare and Venom Research
- Neuropeptides and Animal Physiology
- Urticaria and Related Conditions
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and disorders
- Ginseng Biological Effects and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- S100 Proteins and Annexins
- Takotsubo Cardiomyopathy and Associated Phenomena
- Bioactive Compounds and Antitumor Agents
Xiamen University
2020-2025
Hyogo Medical University
1999-2025
National Cerebral and Cardiovascular Center
2014-2023
Shantou University
1999-2023
First Affiliated Hospital of Shantou University Medical College
2012-2023
Jaeb Center for Health Research
2011
Shantou University Medical College
1999
Atherosclerotic vascular disease (ASVD) is the leading cause of death worldwide. Hyperuricemia fourth risk factor for atherosclerosis after hypertension, diabetes, and hyperlipidemia. The mechanism hyperuricemia affecting occurrence development has not been fully elucidated. Mononuclear macrophages play critical roles in all stages atherosclerosis. Studies have confirmed that both ferroptosis promote atherosclerosis, but whether high level uric acid (HUA) promotes by regulating remains...
Diabet. Med. 28, 1118–1122 (2011) Abstract Aims To describe satisfaction with continuous glucose monitoring in Type 1 diabetes; to correlate scores usage; and identify common themes perceived benefits barriers of reported by adults, youths the parents Juvenile Diabetes Research Foundation trials. Methods The Continuous Glucose Monitoring Satisfaction Scale questionnaire was completed after 6 months monitoring. Participants also answered open‐ended queries positive negative attributes Results...
Clinical studies have shown hyperuricemia strongly associated with insulin resistance as well cardiovascular disease. Direct evidence of how high uric acid (HUA) affects in cardiomyocytes, but the pathological mechanism HUA disease remains to be clarified. We aimed examine effect on sensitivity cardiomyocytes and hyperuricemic mouse model. exposed primary a rat cardiomyocyte cell line, H9c2 HUA, then quantified glucose uptake fluorescent analog, 2-NBDG, after challenge detected reactive...
AMP-activated protein kinase (AMPK) is a central metabolic sensor and plays an important role in regulating glucose, lipid cholesterol metabolism. Therefore, AMPK key therapeutic target diabetes. Recent pilot studies have suggested that diabetes drugs may reduce the risk of cancer by affecting pathway. However, association between proliferation hepatocellular carcinoma (HCC) unknown. In this study, we investigated relationship activity HCC cell lines, nude mice human clinic samples. We first...
Hyperuricemia induces endothelial dysfunction, oxidative stress and inflammation, increasing cardiovascular morbidities. It also raises the incidence of atrial fibrillation; however, underlying mechanisms are unknown.The effects urate on expression Kv1.5 in cultured mouse myocytes (HL-1 cells) using reverse transcriptase-PCR, immunoblots, flow cytometry patch-clamp experiments were studied. Treatment with at 7 mg/dl for 24 h increased protein level, enhanced ultra-rapid delayed-rectifier...
Background/Aims: Clinical studies have shown that hyperuricaemia is strongly associated with cardiovascular disease. However, the molecular mechanisms of high uric acid (HUA) disease remain poorly understood. In this study, we investigated effect HUA on cardiomyocytes. Methods: We exposed H9c2 cardiomyocytes to HUA, then cell viability was determined by MTT assay, and reactive oxygen species’ (ROS) production detected a fluorescence assay. Western blot analysis used examine phosphorylation...
Metformin is an oral biguanide commonly used for treating type II diabetes and has recently been reported to possess antiproliferative properties that can be exploited the prevention treatment of a variety cancers. The mechanisms underlying this effect have not fully elucidated. Our study shows marked loss AMP ‐activated protein kinase ( AMPK ) phosphorylation nuclear human Forkhead box O1 FOXO 1) in estrogen‐dependent endometrial cancer EC tumors compared normal control endometrium....
Hyperuricemia is part of the metabolic-syndrome cluster abdominal obesity, impaired glucose tolerance, insulin resistance, dyslipidemia, and hypertension. Monocytes/macrophages are critical in development metabolic syndrome, including gout, obesity atherosclerosis. However, how high uric acid (HUA) exposure affects monocyte/macrophage function remains unclear. In this study, we investigated molecular mechanism HUA monocytes/macrophages its impact on oxidized low-density lipoprotein...
Background: Gouty arthritis is characterized by the accumulation of monosodium urate crystals (MSU) in synovial joints and surrounding tissues. Mastoparan M (Mast-M) a biologically active peptide composed 14 amino acids, extracted from wasp venom. This study aims to assess impact Mast-M on vitro vivo gouty induced lipolyaccharide (LPS) plus MSU crystal stimulation. Methods: PMA-differentiated THP-1 macrophages were pre-treated with or left untreated, followed stimulation LPS crystals. Cell...
High uric acid (HUA), as a pro-oxidant, plays significant role in the pathophysiology of cardiovascular disease. Studies have indicated that elevated levels can adversely affect health. Nevertheless, impact hyperuricemia on cardiomyopathy remains uncertain. Further research is needed to elucidate relationship between HUA and cardiomyopathy, shedding light its potential implications for heart
Abstract Acute ischemic stroke triggers complex systemic pathological responses for which the exploration of drug resources remains a challenge. Wasp venom extracted from Vespa magnifica (Smith, 1852) is most commonly used to treat rheumatoid arthritis as well neurological disorders. Vespakinin-M (VK), natural peptide wasp venom, has remained largely unexplored stroke. Herein, we first confirmed structure, stability, toxicity and distribution VK its penetration into blood–brain barrier. (150...
Aims: Hyperuricemic nephropathy (HN) represents a prevalent complication of hyperuricemia, typified by tubular dysfunction, inflammation, and progressive renal fibrosis with unclear mechanisms. Ferroptosis, an iron-dependent regulated cell death, is implicated in multiple diseases, but has rarely been linked to HN. In this study, we aim explore the possible role ferroptosis HN its underlying Results: We showed that urate oxidase knockout mice, model exhibited impairment elevated uric acid,...
Aim Numerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state several peripheral tissues to promote development type 2 diabetes mellitus (T2DM). However, effect HUA on glucose uptake and sensitivity macrophages its mechanism is unclear. Methods To assess systemic IR, we generated hyperuricemic mice by urate oxidase...
Insulin resistance is one of the hallmark manifestations obesity and Type II diabetes reversal this pathogenic abnormality an attractive target for new therapies diabetes. A recent report that metformin, a drug known to reverse insulin resistance, demonstrated in vitro metformin can inhibit AMP deaminase (AMPD) activity. Skeletal muscle primary organs contributing AMPD1 gene selectively expressed at high levels skeletal muscle. Recognizing background above, we asked if genetic disruption...
Acute ischaemic stroke (AIS) is a major cause of disability and death, which serious threat to human health life. Wasp venom extracted from Vespa magnifica Smith (Vespidae) could treat neurological disorders.This study investigated the effects wasp on AIS in rats.We used transient middle cerebral artery occlusion (MCAO) model Sprague-Dawley rats (260-280 g, n = 8-15) with sham operation group being treated as negative control. MCAO were (0.05, 0.2 0.6 mg/kg, i.p.) using intraperitoneal...