A5100392170- Gout, Hyperuricemia, Uric Acid
- Food composition and properties
- Polysaccharides Composition and Applications
- Chromatography in Natural Products
- Microbial Metabolites in Food Biotechnology
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Alcohol Consumption and Health Effects
- Analytical Chemistry and Chromatography
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Case Reports on Hematomas
- Ginseng Biological Effects and Applications
- Natural Antidiabetic Agents Studies
- Phytase and its Applications
- Dyeing and Modifying Textile Fibers
- Liver Disease Diagnosis and Treatment
- Natural Products and Biological Research
- Allelopathy and phytotoxic interactions
- Medicinal Plant Pharmacodynamics Research
- Porphyrin Metabolism and Disorders
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Polysaccharides and Plant Cell Walls
- Microbial Natural Products and Biosynthesis
Northeast Petroleum University
2025
Jilin Agricultural University
2023-2025
National Engineering Research Center for Wheat
2023-2025
Qingdao University
2014-2024
Yunnan University
2022-2024
Tianjin University of Science and Technology
2021-2024
First Affiliated Hospital of Anhui Medical University
2018-2024
Anhui Medical University
2018-2024
Hunan University of Traditional Chinese Medicine
2024
Peking University
2010-2023
Three anthraquinones—emodin, chrysophanol, and physcion—were successfully purified from the dichloromethane extract of Chinese medicinal herb Rumex japonicus by high-speed counter-current chromatography (HSCCC). The was separated with n-hexane–ethanol–water (18:22:3, v/v/v) as two-phase solvent system yielded 3.4 mg emodin, 24.1 2.0 physcion 500 sample purities 99.2 %, 98.8% 98.2%, respectively. HSCCC fractions were analyzed high-performance liquid (HPLC) chemical structures three...
Activity-directed fractionation and purification processes were employed to identify xanthine oxidase (XO) inhibitory compounds from the leaves of Perilla frutescens. The total extract was evaluated in vitro on XO activity vivo an experimental model with potassium oxonate-induced hyperuricemia mice which used evaluate anti-hyperuricemic activity. crude showed expressive urate-lowering results. Solvent partitioning followed by macroporous resin column chromatography n-butanol yielded four...
Background/Aims: Clinical studies have shown that hyperuricaemia is strongly associated with cardiovascular disease. However, the molecular mechanisms of high uric acid (HUA) disease remain poorly understood. In this study, we investigated effect HUA on cardiomyocytes. Methods: We exposed H9c2 cardiomyocytes to HUA, then cell viability was determined by MTT assay, and reactive oxygen species’ (ROS) production detected a fluorescence assay. Western blot analysis used examine phosphorylation...
Xanthine oxidase is a key enzyme which can catalyze hypoxanthine and xanthine to uric acid causing hyperuricemia in humans. inhibitory activities of 24 organic extracts four species belonging Citrus genus the family Rutaceae were assayed vitro. Since ethyl acetate extract C. aurantium dried immature fruits showed highest activity, chemical evidence for potent activity was clarified on basis structure identification active constituents. Five flavanones two polymethoxyflavones isolated...
Oxidative stress and inflammatory responses are closely implicated in the progression of renal interstitial fibrosis, thereby leading to chronic kidney disease. Cryptotanshinone (CTS) is a natural compound involved antioxidant anti-inflammatory activities. We evaluated effects CTS on inflammation oxidative obstructed kidneys. Mice received gastric gavage from 7 days before unilateral ureteral obstruction operation 1 week after surgery. Administration at 50 100 mg/kg/day significantly...
In gout, autoinflammatory responses to urate crystals promote acute arthritis flares, but the pathogeneses of tophi, chronic synovitis, and erosion are less well understood. Defining pathways epigenomic immunity training can reveal novel pathogenetic factors biomarkers. The present study was undertaken seminally probe differential DNA methylation patterns utilizing epigenome-wide analyses in patients with gout.
Part of the rotational spectrum hydroxyformyl radical, HOCO, and its deuterated analog has been detected at frequencies between 230 300 GHz. The radical was formed in a flow system by reaction chlorine atoms formic acid. Analysis spectra yields reliable estimates rotational, centrifugal distortion spin–rotational parameters describing ground state this species. constants derived for HOCO DOCO are consistent with planar equilibrium structure used to confirm that carrier is trans-geometrical isomer.
Aim Numerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state several peripheral tissues to promote development type 2 diabetes mellitus (T2DM). However, effect HUA on glucose uptake and sensitivity macrophages its mechanism is unclear. Methods To assess systemic IR, we generated hyperuricemic mice by urate oxidase...