A5070218784- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Liver physiology and pathology
- Inflammatory mediators and NSAID effects
- Gout, Hyperuricemia, Uric Acid
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Chronic Lymphocytic Leukemia Research
- Nerve Injury and Rehabilitation
- Glutathione Transferases and Polymorphisms
- Ginseng Biological Effects and Applications
- Inflammatory Myopathies and Dermatomyositis
- CAR-T cell therapy research
- Genomics, phytochemicals, and oxidative stress
- Alcohol Consumption and Health Effects
- FOXO transcription factor regulation
- Fibroblast Growth Factor Research
- Ocular Diseases and Behçet’s Syndrome
- Radiopharmaceutical Chemistry and Applications
- Effects of Radiation Exposure
- Cancer, Stress, Anesthesia, and Immune Response
- Atherosclerosis and Cardiovascular Diseases
- Macrophage Migration Inhibitory Factor
- Cardiac Arrhythmias and Treatments
Shaanxi University of Chinese Medicine
2021-2025
Peterborough City Hospital
2021
Second Affiliated Hospital of Zhejiang University
2020-2021
Southern Medical University
2021
Xi'an Jiaotong University
2021
Hong Kong Polytechnic University
2019-2020
Ningxia Medical University
2019
West China Hospital of Sichuan University
2014
Sichuan University
2014
Shantou University
2013
As a newly approved oral hypoglycaemic agent, the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin, which is derived from natural product phlorizin can effectively reduce blood glucose. Recent clinical studies have found that dapagliflozin alleviates non-alcoholic fatty liver disease (NAFLD), but specific mechanism remains to be explored. This study aimed investigate underlying of in alleviating hepatocyte steatosis vitro and vivo . We fed spontaneous type diabetes mellitus...
Forkhead box O3 (FOXO3a) is a transcription factor with tumor suppressor functions that plays an important role in prostate cancer. Daidzein, one of the soy isoflavones present soy-based foods, has been shown to exert anti-tumor effects vitro and vivo. We herein investigated inhibitory S-equol, isoflavandiol metabolized from daidzein by bacterial flora intestines, on LnCaP, DU145 PC3 human cancer cell lines. Our results showed S-equol R-equol inhibited growth all three Additional studies...
Wuling capsule is a Chinese patent medicine mainly used for the treatment of chronic liver disease in clinical practice. Our previous work has revealed that could inhibit fibrosis by regulating macrophage polarization, and firstly demonstrated its anti-gout effects on monosodium urate (MSU)- induced acute gouty arthritis (AGA) rats. High uric acid (UA) levels are known to be primary cause gout. Therefore, this study investigated UA lowering, kidney protection underlying mechanisms vivo...
Upregulation of a disintegrin and metalloprotease 9 (ADAM9) is correlated with progression cancers, such as prostate, bladder, pancreatic cancers. However, its role in triple-negative breast cancer (TNBC) still unclear. Our study aimed to investigate whether ADAM9 upregulated promoted the aggressiveness TNBC. Breast cell lines patient specimens were used evaluate expression by western blotting immunohistochemistry staining, respectively. Compared non-TNBC, was significantly increased TNBC...
A lack of efficient diagnostic tools for early and noninvasive diagnosis breast cancer has restricted the clinical treatment effect. This problem might be addressed by combination aggregation-induced emission (AIE) fluorescence imaging positron tomography (PET) with dual advantages high resolution easy operation, unlimited penetration sensitivity. Here, a mitochondria-targeted AIE luminogen (AIEgen) radiolabeled 18 F was developed through two-step radiochemical reaction virtue prosthetic...
Osteoporosis (OP), as a chronic and complex metabolic bone disease, is centred on disturbances in the microcirculatory system, which exacerbates loss damage to microstructure of tissue, resulting increased fragility. Typical clinical manifestations include persistent low back pain, significant increase fracture risk, marked changes spinal morphology, all have serious impact patients' quality life. The incidence osteoporosis (OP) showing year-on-year proportion elderly population continues...
The upper limb consists of four major parts: a girdle formed by the clavicle and scapula, arm, forearm hand. Peripheral nerve lesions are divided into brachial plexus or nerves arising from it. Lesions further (proximal) lower (distal) based on their location. in can be compressed various locations wide range pathologies. A thorough understanding anatomy clinical presentations these compression neuropathies lead to prompt diagnosis management, preventing possible permanent damage. This...
Abstract BACKGROUND Human tumor xenograft models established by transplantation of human cell lines into immunodifficient mice have been routinely used for preclinical test anticancer agents. But a relatively low transplantability and resulted in limited number available selection right testing novel agents based on their antitumor mechanism. Recently, we developed large patient primary non-small lung cancer (NSCLC) transplanting patients’ fresh tissues nude mice, which employed METHODS The...
Background and purpose: Wuling capsule (WL) has good efficacy in the clinical treatment of chronic hepatitis B liver injury. Liver fibrosis is a common pathological feature disease may progress to irreversible cirrhosis cancer. Accumulating evidence reveals that modulating macrophage polarization contribute therapy fibrosis. However, effects WL on relive remain unclear. This study investigated anti-liver carbon tetrachloride (CCl4)-induced rats, modulation underlying molecular mechanism...
Abstract Objectives: As a zinc-dependent proteinase family member, A Disintegrin and Metalloproteinase 9 (ADAM9) has the metalloproteinase domain that performs proteolytic function to liberate or shed factors, such as bFGF, VEGF, EGF, TGF-α IGF, from cell surface make them more accessible tumor cells. It was shown in previous studies upregulation of ADAM9 breast cancer is associated with metastasis. In this study, we examined effect on proliferation, migration invasion elucidated molecular...
Abstract Introduction: A Disintegrin and Metalloproteinase 9 (ADAM9) promotes cancer progression via its metalloproteinase disintegrin domains, upregulated ADAM9 is found in pancreatic, prostate breast carcinomas. The expression of triple negative carcinoma (TNBC), however, still unclear. We investigated the TNBC, role tumor prognostic implication TNBC patients. Materials Methods: was non-TNBC cell lines as well tissues. mRNA data (n = 14) 11) were obtained from Gene Expression Omnibus...
Abstract Background: Zhengyuan prescription (ZYP) is a Chinese herbal medicine used in clinical practice to protect against radiotherapy-induced injuries. In this study, we investigate the protective effect of ZYP X-ray-induced injury human umbilical vein endothelial cells (HUVECs), and explore mechanisms underlying effect. Methods : After 3 h intervention, group were irradiated with 6 Gy X-rays cultured for 48 h. Subsequently, cell viability, morphology, mitochondrial membrane potential,...