A5019623686- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Immune cells in cancer
- PARP inhibition in cancer therapy
- Single-cell and spatial transcriptomics
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Chemical Synthesis and Analysis
- Sarcoma Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- Arctic and Russian Policy Studies
- Retinoids in leukemia and cellular processes
- Colorectal and Anal Carcinomas
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Neurological Disease Mechanisms and Treatments
Shanghai Jiao Tong University
2023-2025
XinHua Hospital
2023-2025
Second Military Medical University
2017-2024
China Agricultural University
2024
General Hospital of Central Theater Command
2023-2024
Wuhan General Hospital of Guangzhou
2023-2024
Chinese PLA General Hospital
2024
Eastern Hepatobiliary Surgery Hospital
2021-2022
State Council of the People's Republic of China
2022
Hebei Medical University
2019-2021
Abstract Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, mechanisms underlying genomic, transcriptomic epigenetic alternations RCC progression have not been completely defined. In this study, single-cell RNA-sequencing (scRNA-seq) data were obtained from eight tissue samples of patients, including two matched pairs primary metastatic sites (lymph nodes), along with Hi-C,...
Purpose: Cancer stem-like cells (CSC) contribute to the progression and androgen deprivation therapy (ADT) resistance of prostate cancer. As CSCs depend on their specific niche, including tumor-associated macrophages (TAM), elucidating network between TAMs may help effectively inhibit ADT cancer.Experimental Design: The underlying intracellular mechanism that sustains characteristics in cancer was assessed via RNA sequencing, co-immunoprecipitation, chromatin immunoprecipitation, other...
Purpose: Androgen deprivation therapy (ADT), including enzalutamide, induces resistance in prostate cancer; ADT is associated with neuroendocrine differentiation (NED) and tumor-associated macrophages (TAM). This study aimed to investigate the association between enzalutamide-induced NED TAMs its mechanism.Experimental Design: The was investigated by IHC using cancer tissues, enzalutamide-resistant mouse xenografts, a coculture system. underlying mechanisms were assessed vitro cytokine...
Tumor-associated macrophages (TAMs) are closely related to unfavorable prognosis of patients with clear cell renal carcinoma (ccRCC). However, the important molecules in interaction between ccRCC and TAMs unclear.TCGA-KIRC gene expression data tumor tissues normal adjacent were compared identify differentially expressed genes ccRCC. discovered by analyzing correlation these common macrophage biomarkers. Gene set enrichment analysis was performed predict functions gene. The findings further...
Abstract Renal cell carcinoma (RCC) is considered a “metabolic disease” characterized by elevated glycolysis in patients with advanced RCC. Tyrosine kinase inhibitor (TKI) therapy currently an important treatment option for RCC, but drug resistance may develop some patients. Combining TKI targeted metabolic provide more effective approach An analysis of 14 RCC (including three needle biopsy samples resistance) revealed sing-cell RNA sequencing (scRNA-seq) that played crucial role poor...
The aim of this study was to explore the key genes, microRNA (miRNA), and pathogenesis oral squamous cell carcinoma (OSCC) at molecular level through analysis bioinformatics, which could provide a theoretical basis for screening drug targets. Data OSCC were obtained from Gene Expression Omnibus (GEO) database. differentially expressed genes (DEGs) identified via GEO2R analysis. Next, protein–protein interaction (PPI) network DEGs constructed Search Tool Retrieval Interacting visualized...
Tertiary lymphoid structures (TLSs) serve as organized aggregates that influence immune responses within the tumor microenvironment. This study aims to investigate characteristics and clinical significance of TLSs tumor-infiltrating lymphocytes (TILs) in clear cell renal carcinoma (ccRCC). TILs were analyzed comprehensively 754 ccRCC patients from 6 academic centers 532 The Cancer Genome Atlas. Integrated analysis was performed based on single-cell RNA-sequencing datasets 21 TLS...
Renal cell carcinoma (RCC) is the most common form of kidney cancer, caused by renal epithelial cells. RCC remains to be a challenging public health problem worldwide. Metastases that are resistant radiotherapy and chemotherapy major cause death from cancer. However, underlying molecular mechanism regulating metastasis poorly known. Publicly available databases were obtained Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) identified using GEO2R analysis,...
TSPAN7 is an important factor in tumor progression. However, the precise function of and its role pan-cancer are not clear. Based on Xinhua cohort incorporating 370 patients with kidney neoplasm, we conducted differential expression analysis by immunohistochemistry between normal tissues, explored correlations patients' survival. Subsequently, a study, successively employed analysis, competing endogenous RNA (ceRNA) protein-protein interaction (PPI) correlation clinical characteristics,...
Clear cell renal carcinoma (ccRCC) is a frequent malignant tumor of the kidney which has dismal prognosis. At present, targeted therapies and immunotherapy have achieved significant results; however, overall survival rate patients with ccRCC remains unacceptably poor. It therefore necessary to find novel therapeutic diagnostic targets for ccRCC. been reported that enolase 2 (ENO2) an oncogene, although its function in immune microenvironment growth yet be fully elucidated. The present study...
Increasing evidence reveals that the interaction between tumor cells and tumor-associated macrophages (TAMs) facilitates progression of prostate cancer, but related mechanisms remained unclear. This study determined how gankyrin, a component 19S regulatory complex 26S proteasome, regulates androgen deprivation therapy (ADT) resistance cancer through cell-TAM interactions. In vitro functional experiments in vivo subcutaneous models were used to explore biological role molecular gankyrin 234...
Renal cell carcinoma (RCC) is a heterogeneous malignancy with diverse gene expression patterns, molecular landscapes, and differentiation characteristics of tumor cells. It imperative to develop RCC classification based on for precise risk stratification personalized therapy. We obtained scRNA-seq profiles from GSE159115 bulk RNA-seq TCGA-KIRC cohort. then performed cluster analysis, monocle2 pseudotime prognostic analysis obtain differentiation-related genes (TCDGs). Subsequently, we...
e16514 Background: The obesity paradox in clear cell renal carcinoma (ccRCC) has drawn attention, with studies suggesting perirenal fat may serve as an immune reservoir, influencing the tumor microenvironment and prognosis. However, its specificity clinical relevance compared to BMI remain uncertain, prognostic utility patient management is underexplored. This study evaluates significance of thickness (PRFT) potential improve prediction models, particularly for small tumors (≤4 cm). Methods:...
Renal cell carcinoma (RCC) is a hypermetabolic disease. Abnormal up-regulation of glycolytic signaling promotes tumor growth, and metabolism closely related to immunotherapy renal cancer. The aim the present study was determine whether how glycolysis-related biomarker TCIRG1 affects aerobic glycolysis, microenvironment (TME) malignant progression clear (ccRCC).Based on Cancer Genome Atlas (TCGA, n = 533) gene set from MSigDB, we identified by bioinformatics analysis, analyzed its...
Background: Pyroptosis is a programmed death mode of inflammatory cells, which closely related to tumor progression and immunity.Clear cell renal carcinoma (ccRCC) the major pathological type (RCC) with poor prognosis.Many theories have tried clarify mechanism in development ccRCC, but role pyroptosis ccRCC has not been well described.The main purpose this study explore establish novel prognosis prediction model pyroptosis-related molecular signatures for ccRCC.Methods: In present study, we...
In improving agricultural yields and ensuring food security, precise detection of maize leaf diseases is great importance. Traditional disease methods show limited performance in complex environments, making it challenging to meet the demands for modern agriculture. This paper proposes a model based on state-space attention mechanism, aiming effectively utilize spatiotemporal characteristics achieve efficient accurate detection. The introduces mechanism combined with multi-scale feature...
Previous bulk RNA sequencing or whole genome on clear cell renal carcinoma (ccRCC) subtyping mainly focused ccRCC origin the complex tumor microenvironment (TME). Based single-cell (scRNA-seq) data of 11 primary specimens, cancer stem-cell-like subsets could be differentiated into five trajectories, whereby we further classified cells three groups with diverse molecular features. These subgroups showed significantly different outcomes and potential targets to tyrosine kinase inhibitors...
BACKGROUND:Esophageal carcinoma (ESCA) is associated with a poor prognosis and high mortality rate. Autophagy plays important roles in promoting or suppressing tumor cell survival at different stages of cancer development. However, the autophagy-related genes (ARGs) during ESCA progression patient remain unclear. Accordingly, this study, we aimed to identify relationships ARGs prognosis. MATERIAL AND METHODS:Clinicopathological information for patients was downloaded from The Cancer Genome...
Although many intratumoral biomarkers have been reported to predict clear cell renal carcinoma (ccRCC) patient prognosis, combining and clinical indicators could ccRCC prognosis more accurately than any of these markers alone. This study mainly examined the prognostic value HECT, C2 WW domain-containing E3 ubiquitin protein ligase 1 (HECW1) expression in patients combination with established indicators.The level HECW1 was screened out by data-independent acquisition mass spectrometry...