A5055761984- Genomics, phytochemicals, and oxidative stress
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Advanced Graph Neural Networks
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- RNA Research and Splicing
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Cancer-related gene regulation
- Genomic variations and chromosomal abnormalities
- Burn Injury Management and Outcomes
- Cancer Cells and Metastasis
- Topic Modeling
- Plant Disease Resistance and Genetics
- Molecular Biology Techniques and Applications
- Cardiac Arrest and Resuscitation
- Ubiquitin and proteasome pathways
Moffitt Cancer Center
2020-2025
Tongji Hospital
2014-2024
University of Notre Dame
2022-2024
Tongji University
2023-2024
First Affiliated Hospital of Zhengzhou University
2024
Second Military Medical University
2017-2023
XinHua Hospital
2022-2023
Medical College of Wisconsin
2017-2021
Changchun Obstetrics and Gynecology Hospital
2020
University of South Florida
2020
Generative self-supervised learning (SSL), especially masked autoencoders, has become one of the most exciting paradigms and shown great potential in handling graph data. However, real-world graphs are always heterogeneous, which poses three critical challenges that existing methods ignore: 1) how to capture complex structure? 2) incorporate various node attributes? 3) encode different positions? In light this, we study problem generative SSL on heterogeneous propose HGMAE, a novel...
Large language models (LLMs) have shown remarkable generalization capability with exceptional performance in various modeling tasks. However, they still exhibit inherent limitations precisely capturing and returning grounded knowledge. While existing work has explored utilizing knowledge graphs (KGs) to enhance via joint training customized model architectures, applying this LLMs is problematic owing their large number of parameters high computational cost. Therefore, how pre-trained using...
Abstract Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles the male sex hormone androgen its receptor (AR) in melanoma, cellular molecular mechanisms underlying these sex-associated discrepancies poorly defined. Here, we delineate a previously undisclosed mechanism by which androgen-activated AR transcriptionally upregulates fucosyltransferase 4 ( FUT4 ) expression, drives melanoma invasiveness...
We evaluated whether 5hmC signatures in cell-free DNA (cfDNA) are associated with treatment failure to androgen-deprivation therapies (ADT) among men hormone-naive prostate cancer. collected a total of 139 serial plasma samples from 55 cancer patients receiving ADT at 3 time points including baseline (before initiating ADT, n = 55); months (after and disease progression (n 15) within 24 or if no was detected 14). used selective chemical labeling sequencing quantify abundance across the...
Functional characterization of disease-causing variants at risk loci has been a significant challenge. Here we report high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) technology to simultaneously screen hundreds thousands SNPs for their allele-dependent protein-binding differences. This takes advantage higher retention rate protein-bound DNA oligos in protein purification column quantitatively sequence these SNP-containing oligos. We apply this test prostate cancer-risk...
Plasma exosomal miRNAs were evaluated for prognosis in an initial set of 44 metastatic renal cell cancer (mRCC) patients by RNA sequencing. Among ∼3.49 million mappable reads per patient, accounted 93.1% the mapped RNAs. 227 with high abundance selected survival analysis. Cox regression analysis identified association 6 overall (OS) (P<0.01, False discovery rate (FDR) < 0.3). Five associated quantified independent follow-up cohort 65 mRCC TaqMan-based miRNA assays. Kaplan-Meier confirmed...
Abstract Polo-like kinase 1 (PLK1) is an essential cell-cycle regulator that frequently overexpressed in various human cancers. To determine whether Plk1 overexpression drives tumorigenesis, we established transgenic mouse lines ubiquitously express increased levels of Plk1. High were a driving force for different types spontaneous tumors. Increased resulted multiple defects mitosis and cytokinesis, supernumerary centrosomes, compromised checkpoints, allowing accumulation chromosomal...
Cluster of differentiation 44 (CD44) is a transmembrane glycoprotein that serves as the receptor for extracellular matrix component hyaluronic acid. CD44 has been reported to play key roles in cell proliferation, motility, and survival, but its role breast cancer remains controversial. In this study, we conducted meta-analysis. A total 23 published Gene Expression Omnibus databases were included evaluate association between mRNA expression clinicopathological characteristics or prognosis...
Cluster of differentiation 44 (CD44), a well-known transmembrane glycoprotein, serves as promoting factor in the carcinogenesis and progression variety neoplasms. Previous studies have demonstrated that aberrant expression CD44 was associated with initiation, invasion, metastasis, therapy-resistance breast cancer, but whether there any association between pathological characteristics cancer or epidermal growth receptor (EGFR) has not been clearly elucidated. In this study, we utilized public...
Abstract Prostate cancer (PCa) risk-associated SNPs are enriched in noncoding cis-regulatory elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we perform CRISPRi screens of 260 rCREs PCa cell lines. We find that harboring high risk more essential for proliferation H3K27ac occupancy is a strong indicator essentiality. also show cell-line-specific the 8q24.21 region, with rs11986220-containing rCRE regulating MYC PVT1 expression, tumorigenesis manner,...
The objective of this study was to evaluate the effect platinum-based drugs on nuclear-factor erythroid2 like 2 (NRF2) signaling in non-small cell lung cancer lines with or without Kelch-like ECH-associated protein 1 (KEAP1) mutations and determine role NRF2 KEAP1 drug treatment. We used real-time PCR assess relative mRNA expression western blotting immunofluorescence assays expression. Small interfering RNA shuttle plasmids were modulate NRF2, wild-type KEAP1, mutant KEAP1. Drug sensitivity...
Graph neural networks (GNNs) have shown remarkable performance on diverse graph mining tasks. While sharing the same message passing framework, our study shows that different GNNs learn distinct knowledge from graph. This implies potential improvement by distilling complementary multiple models. However, distillation (KD) transfers high-capacity teachers to a lightweight student, which deviates scenario: are often shallow. To transfer effectively, we need tackle two challenges: how compact...
Abstract Renal cell carcinoma (RCC) is considered a “metabolic disease” characterized by elevated glycolysis in patients with advanced RCC. Tyrosine kinase inhibitor (TKI) therapy currently an important treatment option for RCC, but drug resistance may develop some patients. Combining TKI targeted metabolic provide more effective approach An analysis of 14 RCC (including three needle biopsy samples resistance) revealed sing-cell RNA sequencing (scRNA-seq) that played crucial role poor...
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein expressed primarily in the liver, formerly known to maintain plasma lipid homeostasis by regulating low-density lipoprotein receptor levels, and its exact role radioresistance of prostate cancer (PCa) remains unclear. We aim investigate function PCSK9 PCa cells. Methods: small interfering RNA (siRNA) was introduced into cells transient transfection. Then, were exposed ionizing radiation (IR) at indicated dose...
Recipe recommendation systems play an essential role in helping people decide what to eat. Existing recipe typically focused on content-based or collaborative filtering approaches, ignoring the higher-order signal such as relational structure information among users, recipes and food items. In this paper, we formalize problem of with graphs incorporate into through graph modeling. particular, first present URI-Graph, a new large-scale user-recipe-ingredient graph. We then propose RecipeRec,...
Genome-wide association studies have identified 270 loci conferring risk for prostate cancer (PCa), yet the underlying biology and clinical impact remain to be investigated. Here we observe an enrichment of transcription factor genes including HNF1B within PCa risk-associated regions. While focused on 17q12/HNF1B locus, find a strong eQTL multiple potential causal variants involved in regulation expression PCa. An unbiased genome-wide co-expression analysis reveals PCa-specific somatic...
Circulating exosomes in the blood are promising tools for biomarker discovery cancer. Due to their heterogeneity, different isolation methods may enrich distinct exosome cargos generating omic profiles. In this study, we evaluated effects of plasma on detectable multi-omic profiles patients with non-small cell lung cancer (NSCLC), castration-resistant prostate (CRPC), and healthy controls, developed an algorithm quantify enrichment. Plasma were isolated from CRPC (n = 10), NSCLC 14),...