A5103246776- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Cancer-related gene regulation
- Ginseng Biological Effects and Applications
- Neurological diseases and metabolism
- Prostate Cancer Treatment and Research
- Genomic variations and chromosomal abnormalities
- Tryptophan and brain disorders
- Retinal Development and Disorders
- Circular RNAs in diseases
- Genetic and rare skin diseases.
- Hereditary Neurological Disorders
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Cancer, Lipids, and Metabolism
- Virus-based gene therapy research
- Molecular Biology Techniques and Applications
- Retinopathy of Prematurity Studies
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Galectins and Cancer Biology
- Prenatal Screening and Diagnostics
Shanghai Jiao Tong University
2018-2025
Renji Hospital
2022-2025
Jiangmen Central Hospital
2025
Chengdu University of Traditional Chinese Medicine
2021-2024
XinHua Hospital
2018-2024
Ninghai First Hospital Medicare and Health Group
2024
Shanghai University of Traditional Chinese Medicine
2022
Wenzhou Medical University
2018-2019
First Affiliated Hospital of Wenzhou Medical University
2018-2019
Xiangya Hospital Central South University
2007-2008
Abstract Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss heterogeneity on short arms chromosome 3 9 have been reported be associated NPC, a genome-wide scan identified NPC susceptibility locus 4p15.1-q12 recently. In our study, we collected samples 18 families at high risk Hunan province China, genotyped panel polymorphic markers chromosomes 3,...
The development of lethal cancer metastasis depends on the dynamic interactions between cells and tumor microenvironment, both which are embedded in extracellular matrix (ECM). acquisition resistance to detachment-induced apoptosis, also known as anoikis, is a critical step metastatic cascade. Thus, more in-depth systematic analysis needed identify key drivers anoikis resistance.Genome-wide CRISPR/Cas9 knockout screen was used using SKOV3 cell line found protein-L-isoaspartate (D-aspartate)...
Kidney fibrosis, the excessive accumulation and dysregulated remodeling of extracellular matrix, is principal pathophysiological process in chronic kidney disease (CKD). Protein L-isoaspartyl/D-aspartyl methyltransferase (PCMT1) crucial repairing post-translational modifications L-isoaspartyl residues, which are important for matrix proteins because their low turnover rate susceptibility to accelerating factors. This study aimed reveal a novel role PCMT1 fibrosis. tissues from mice humans...
Triple-negative breast cancer (TNBC) poses a challenging prognosis due to early metastasis driven by anoikis resistance. Identifying crucial regulators overcome this resistance is vital for improving patient outcomes. In study, genome-wide CRISPR/Cas9 knockout screen in TNBC cells has identified tyrosine-protein phosphatase nonreceptor type 14 (PTPN14) as key regulator of PTPN14 expression shown progressive decrease from normal tissue metastatic tumors. Overexpressing induced and inhibited...
Ferroptosis is a kind of cell death triggered by intracellular phospholipid peroxidation. Human umbilical vein blood endothelial progenitor cells-Exosomes (EPCs-Exos) affect ferroptosis. This study sought to explore the mechanism EPCs-Exos in human (HUVEC) were isolated and identified. HUVECs treated with Erastin at IC50 concentration. Ferroptosis-related indexes iron ion content detected using kits. HUVEC migration angiogenesis before/after ferroptosis inhibitor treatment observed scratch...
Messenger RNA (mRNA) carries genetic instructions to the cell machinery for transient production of antigens or therapeutic proteins and shows enormous potential in vaccine development, cancer immunotherapy, protein replacement therapy, genome engineering. Here, synthesis chemically modified nerve growth factor mutant (NGFR100W ) mRNA through vitro transcription is described. After original signal peptide sequence with Ig Kappa leader sequence, codon-optimized NGFR100W yielded high secretion...
Chronic kidney disease (CKD) is characterized by persistent damage to function or structure. Progression end-stage leads adverse effects on multiple systems. However, owing its complex etiology and long-term cause, the molecular basis of CKD not completely known. To dissect potential important molecules during progression, based databases from Gene Expression Omnibus, we used weighted gene co-expression network analysis (WGCNA) identify key genes in tissues peripheral blood mononuclear cells...
Journal Article A novel locus (DSAP2) for disseminated superficial actinic porokeratosis maps to chromosome 15q25.1–26.1 Get access K. Xia, Xia National Laboratory of Medical Genetics K.Xia. E‐mail: nlmglcy@xymu.net Search other works by this author on: Oxford Academic Google Scholar H. Deng, Deng J.H. D. Zheng, Zheng H.L. Zhang, Zhang C.Y. Lu, Lu C.Q. Li, Li Department Dermatology, Xiangya Hospital, and Q. Pan, Pan H.P. Dai, Dai Y.F. Yang, Yang Thoracic Surgery, Second Central South...
Proteins are constantly damaged by intracellular and extracellular factors, particularly under stress conditions, leading to an accumulation of modified proteins such as isoaspartate (isoD), which is linked aging various diseases. The repair enzyme PCMT1 (protein-l-isoaspartate o-methyltransferase) specifically restores isoD residues aspartate, preventing abnormal protein functions. Despite its importance, role in non-neural tissues remains underexplored. This study employed isoD-proteomics,...
Caspase-8 is a unique member of caspases with dual role in cell death and survival. expression often lost some tumors, but increased others, indicating potential pro-survival function cancer. By analyzing transcriptome enzalutamide-resistant prostate cancer cells, we found that resistance was conferred by mild caspase-8 upregulation turn led to NF-κB activation the subsequent downstream IL-8. Mechanistically, enzalutamide-resistance-promoting features were independent its proteolytic...
Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those strong responses achieve sterilizing immunity. Thus far, biomarkers associated levels vaccine-elicited still lacking. Here, we studied the age- and gender-controlled healthy cohort, who received inactivated vaccines profiled B cell receptor repertoires longitudinally...
Research Articles| May 20 2008 Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization Subject Area: Genetics L. Xu; Xu aNational Laboratory Medical Genetics, Hunan University, Changsha, (China); Search for other works this author on: This Site PubMed Google Scholar H.X. Deng; Deng bDepartment Neurology, Northwestern University School, Chicago IL (USA) Y. Yang; Yang J.H. Xia; Xia W.Y. Hung; Hung T. Siddque Cytogenetics and Cell...
Background Our previous study has identified two loci for disseminated superficial actinic porokeratosis (DSAP), but the genes responsible are still unknown. Objectives To narrow down candidate regions and to assess genes. Methods A genome‐wide scan linkage analysis were carried out in a newly collected five‐generation Chinese family with DSAP. In addition, six screened possible DSAP‐associated mutations. Results DSAP this was associated chromosome 12q. Fine mapping haplotype construction...
Background: Enzalutamide, a novel androgen receptor (AR) signaling inhibitor, has been widely used to increase survival in patients with castration-resistant prostate cancer. However, resistance enzalutamide invariably develops.Methods: To understand the underlying mechanisms of enzalutamide, we performed integrative analysis on multiple transcriptome datasets identify those genes constantly up- or down-regulated response treatment.Results: There were 703 and 581 differentially expressed...