A5101536709- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Aortic aneurysm repair treatments
- Erythrocyte Function and Pathophysiology
- Aortic Disease and Treatment Approaches
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Parathyroid Disorders and Treatments
- Nutrition, Genetics, and Disease
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
- Muscle Physiology and Disorders
- Orthopaedic implants and arthroplasty
- Blood properties and coagulation
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Leaf Properties and Growth Measurement
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Polymer Surface Interaction Studies
- Neurogenesis and neuroplasticity mechanisms
Ministry of Agriculture and Rural Affairs
2025
Second Affiliated Hospital of Zhejiang University
2017-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Chongqing Medical University
2022-2024
Zhejiang University
2015-2024
Augusta University
2020-2023
First Affiliated Hospital Zhejiang University
2019-2023
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2023
Shanghai Children's Medical Center
2023
Shanghai Jiao Tong University
2023
Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim this study was to investigate whether exosomes from hypoxia-treated MSCs (ExoH) are superior those normoxia-treated (ExoN) for myocardial repair. Mouse bone marrow-derived were cultured under hypoxia or normoxia 24 h, and conditioned media intramyocardially injected into infarcted heart C57BL/6 mouse. ExoH resulted in significantly higher survival, smaller scar size better cardiac functions recovery....
Abstract Hydrogel structures equipped with internal microchannels offer more in vivo‐relevant models for construction of tissues and organs vitro. However, currently used microfabrication methods constructing microfluidic devices are not suitable the handling hydrogel. This study presents a novel method fabricating hydrogel‐based chips by combining casting bonding processes. A twice cross‐linking strategy is designed to obtain interface that has same strength hydrogel bulk, which can be...
Hemodynamic overload induces pathological cardiac hypertrophy, which is an independent risk factor for intractable heart failure in long run. Beyond neurohumoral regulation, mechanotransduction has been recently recognized as a major regulator of hypertrophy under myriad conditions. However, the identification and molecular features mechanotransducer on cardiomyocytes are largely sparse. For first time, we identified Piezo1 (Piezo type mechanosensitive ion channel component 1), novel with...
Background: Vascular homeostasis is maintained by the differentiated phenotype of vascular smooth muscle cells (VSMCs). The landscape protein coding genes comprising transcriptome VSMCs has been intensively investigated but many gaps remain including emerging roles noncoding genes. Methods: We reanalyzed large-scale, publicly available bulk and single-cell RNA sequencing datasets from multiple tissues cell types to identify VSMC-enriched long RNAs. in vivo expression pattern a novel...
The pore morphology design of bioceramic scaffolds plays a substantial role in the induction bone regeneration. Specifically, effects different scaffold geometry designs on angiogenesis and new regeneration remain unclear. Therefore, we fabricated Mg/Sr co-doped wollastonite (MS-CSi) with three geometries (gyroid, cylindrical, cubic) compared their osteogenesis vitro vivo. MS-CSi were by digital light processing (DLP) printing technology. structure, mechanical properties, degradation rate...
Percutaneous vertebroplasty (PVP) is a surgical procedure that has been widely used to treat patients suffering from osteoporotic vertebral compression fractures (OVCFs). The involves injection of bone cement into fractured vertebra. In this study, we investigated whether the distribution in body related occurrence recompression after surgery.A total 172 diagnosed with OVCF, January 2008 June 2013, were retrospectively reviewed. Fifty these experienced surgery during follow-up period...
Primary familial brain calcification is a monogenic disease characterized by bilateral calcifications in the basal ganglia and other regions, commonly presents motor, psychiatric, cognitive symptoms. Currently, four autosomal dominant (SLC20A2, PDGFRB, PDGFB, XPR1) one recessive (MYORG) causative genes have been identified. Compared with patients primary calcification, form of present more severe clinical imaging phenotypes, deserve research attention. Biallelic mutations MYORG cannot...
Abstract Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis progression, but the functional changes VSMCs and associated cellular crosstalk during progression remain unknown. Here we show that scRNA-seq analysis of proximal adjacent (PA) atherosclerotic core (AC) regions human carotid artery plaques identifies alterations macrophage-like VSMCs, elucidating main state differences between PA AC VSMCs. And, IL-1β mediates macrophage-macrophage-like VSMC through...
Background: Angiogenesis is a promising strategy for those with peripheral artery disease. Macrophage-centered inflammation intended to govern the deficiency of angiogenic response after hindlimb ischemia. However, little known about mechanism macrophage activation beyond signals from cytokines and chemokines. We sought identify novel mechanical signal ischemic microenvironment that provokes macrophages subsequent inflammatory cascade investigate potential role Piezo-type mechanosensitive...
Abstract Zwitterionic hydrogels exhibit great potential in biomedical applications due to their antifouling properties and biocompatibility. However, the single‐network structure of pure zwitterionic leads a low toughness strength, limiting application fields. In this work, high entanglement sulfobetaine methacrylate‐dopamine hydrogel (SBMA‐DA‐PE) with cross‐linker content monomer concentration is prepared by using dopamine oxidative radical polymerization method. Compared regular hydrogel,...
Fresh sweet and waxy maize (Zea mays) are valuable specialty crops in southern China. Hyperspectral remote sensing offers a powerful tool for detecting foliar nutrients non-destructively. This study aims to investigate the capability of leaf spectroscopy (SVC HR-1024i spectrometer, wavelength range: 400–2500 nm) retrieve nutrients. Specifically, we (1) explored effects nitrogen application rates (0, 150, 225, 300, 450 kg·N·ha−1), cultivars (GLT-27 TGN-932), growth stages (third (vegetation...
To date, our understanding of the role HO-1 (heme oxygenase-1) in inflammatory diseases has mostly been limited to its catalytic function and potential for heme-related catabolic products suppress inflammation oxidative stress. Whether how macrophages plays a development septic cardiac dysfunction never explored.Here, we investigated macrophage-derived dysfunction.Intraperitoneal injection lipopolysaccharide significantly activated expression infiltrated macrophages. Surprisingly, found that...
Vascular calcification (VC) is a marker of the severity atherosclerotic disease. Hormones play important roles in regulating calcification; estrogen and parathyroid hormones exert opposing effects, former alleviating VC latter exacerbating it. To date no treatment strategies have been developed to regulate clinical VC.The objective this study was investigate effect growth hormone-releasing hormone (GHRH) its agonist (GHRH-A) on blocking mouse model.Young adult osteoprotegerin-deficient mice...
Bio-sourced hydrogels are attractive materials for diagnosing, repairing and improving the function of human tissues organs. However, their mechanical strength decreases with an increase in water content. Furthermore, it is challenging to mold these high precision, which significantly limits applications. Herein, we modified a biocompatible biodegradable material, hyaluronic acid, methacrylic anhydride then cured four-arm star structure cross-linking agent under ultraviolet light. The acid...
Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarction (MI). Accumulating data show that ischemia, sympathetic activation, and inflammation contribute to arrhythmogenesis. However, the role mechanisms abnormal mechanical stress in ventricular arrhythmia MI remain undefined. We aimed examine impact increased identify sensor Piezo1 MI. Concomitant with pressure, Piezo1, as newly recognized mechano-sensitive cation channel, was most up-regulated...
Acute lung injury (ALI) causes inflammation and edema as well resulting in gut microbiota disorder. Probiotics, however, can improve the composition modulate its immune response, playing an important role ALI pathogenesis. Therefore, our study aims to investigate effect of Lactobacillus reuteri on Lipopolysaccharide (LPS)-induced mice probe mechanism synergistic modulatory lungs intestines. We assessed therapeutic effects L. mouse model by histopathology, alveolar lavage fluid serum...
Abstract Lipofectamine 2000 (Lipo2000) delivery system is commonly used for short interfering RNA (siRNA) transfection, whereas the cellular responses have attracted little attention. The purpose of this study to evaluate effect siRNA transfection using Lipo2000 on functions and possible underlying mechanism. Primary human umbilical vein endothelial cells (HUVECs) adult coronary artery cell line (HCAECs) were treated with different concentrations a Lipo2000/negative control (NC siRNA)...