A5110375137- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Pancreatic function and diabetes
- Ion Channels and Receptors
- Lanthanide and Transition Metal Complexes
- Selenium in Biological Systems
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Neurobiology and Insect Physiology Research
- Crystal structures of chemical compounds
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
- Trace Elements in Health
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Tetrazole Derivatives
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- DNA and Nucleic Acid Chemistry
- Parkinson's Disease Mechanisms and Treatments
- RNA modifications and cancer
- Calcium signaling and nucleotide metabolism
- Bone Metabolism and Diseases
- Electrocatalysts for Energy Conversion
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Nano Carbon (Poland)
2025
Sichuan University
2019-2024
State Key Laboratory of Oral Diseases
2019-2024
China Pharmaceutical University
2018-2023
Dalian Medical University
2019-2023
Second Affiliated Hospital of Dalian Medical University
2023
Xi'an Jiaotong University
2020-2022
National Health and Family Planning Commission
2020-2022
Abstract Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed nerves, mechanical loads-induced withdrawal using orthodontic tooth movement (OTM) model. Firstly, was activated after 3rd day OTM, coinciding with a decrease nerves an increase pain threshold. Sema3A, rather than growth factor (NGF), highly both trigeminal ganglion axons periodontal ligament following OTM. Moreover,...
Two proteins, STIM1 in the endoplasmic reticulum and Orai1 plasma membrane, are required for activation of Ca(2+) release-activated (CRAC) channels at cell surface. How these proteins interact to assemble functional CRAC has remained uncertain. Here, we determine how many molecules form a channel. We engineered several genetically expressed fluorescent tandem multimers fluorescent, constitutively active mutant. The assembled into channels, as seen by rectifying inward currents cytoplasmic...
Fixed appliances have been the mainstream for orthodontic treatment, while clear aligners, such as Invisalign system, become increasingly popular. The prevalence of apical root resorption (ARR) in patients with aligners is still controversial. aim this study was to investigate and compare severity ARR treated fixed using cone beam computed tomography (CBCT).A total 373 roots from 70 subjects, similar baseline characteristics ABO discrepancy index scores (i.e., treatment difficulty), were...
Background/Aims: Long noncoding RNAs (lncRNAs) have recently emerged as novel and potentially promising therapeutic targets in various cancers. However, the expression pattern biological function of lncRNAs glioma remain largely elusive. In present study, we investigated functional role an lncRNA, small nucleolar RNA host gene 16 (SNHG16), glioma. Methods: The levels SNHG16 miR-4518 were measured using qRT-PCR. relationship between clinicopathologic features statically analyzed. proteins...
Long noncoding RNAs (lncRNAs) play important roles in the development and progression of human cancers. The lncRNA prostate cancer-associated transcript 1 (PCAT1) has been reported to be involved multiple cancers, including oesophageal squamous cell carcinoma (ESCC). However, detailed biological functions, underlying mechanisms clinical relevance PCAT1 ESCC remain unclear. Here, we confirmed that was highly expressed tissues lines. Knockdown inhibited growth cells, whereas overexpression...
CalliSpheres® Beads (CB) is the first drug-eluting bead (DEB) product in China. Our aim was to compare effect on pharmacokinetics of doxorubicin (DOX) and its local concentration between lipiodol emulsions CB process TACE rabbit livers. Twenty-five rabbits were distributed into two groups; Group 1 received with DOX, 2 loaded DOX (CBDOX). measured peripheral blood at different times after treatment. Livers sampled week month for embolization. distribution liver. The administration by CBDOX...
Abstract Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the detailed mechanisms by which tumor cells evade premature to malignant progression remain largely elusive. Here we reported that RBM4 adversely impacted cellular favor glutamine-dependent survival of esophageal squamous cell carcinoma (ESCC) dictating activity LKB1, critical governor cancer metabolism. The level was specifically elevated ESCC...
The safe and functional delivery of progesterone through the vaginal route remains an unmet clinical need. purpose this work is to prepare a new (P4) gel for application using thermosensitive mucoadhesive polymer, glycol chitin (GC). Thermogelling, mucoadhesive, mechanical, viscoelastic properties GC formulation were evaluated rheometry. In vitro release profile bioactivity P4 determined fluid simulant (VFS) pH 4.2, PR-reporter gene assay, respectively. safety formulations was tested...
// Yu Zhang 1, 3 , Jing-Jing Yan Tian Zheng-Zheng Li Cai-Yi Shu-Fen Lan-Qin Cao Yi Chen-Yue Qian 2 Wei Hong-Hao Zhou Ji-Ye Yin Zhao-Qian Liu 1 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China Institute Hunan Key Laboratory Pharmacogenetics, 410078, Obstetrics & Gynecology, Correspondence to: Liu, e-mail: liuzhaoqian63@126.com Yin, yinjiye@csu.edu.cn Keywords: eIF3a, platinum, ovarian cancer, drug resistance, XPC Received: April 30,...
Abstract Background Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by infiltration immune cells into brain and demyelination. The unwanted immunosuppressive side effect therapeutically successful natalizumab led us to focus on choroid plexus (CP), a key site for first wave cell in experimental encephalomyelitis (EAE), control trafficking. Adenosine A 2A receptor (A R) emerging as potential pharmacological target EAE pathogenesis. However, cellular basis...
Human mesenchymal stem cells (hMSCs) possess the potential to differentiate into endothelial (EC). DNA methylation plays an important role in cell differentiation during development. However, of methyltransferases Dnmt1 and Dnmt3a specific arterial hMSCs is not clear. Here, we show that CpG islands promoter regions EC specification marker genes were highly methylated based on bisulfite genomic sequencing. Treatment with DNMT inhibitor 5-aza-dc induced reactivation by promoting demethylation...
Animal models for Parkinson's disease (PD) are very useful in understanding the pathogenesis of PD and screening new therapeutic approaches. The present study compared two commonly used neurotoxin‑induced mouse chronic to guide model selection, explore mechanisms underlying develop effective treatments. were established via treatment with rotenone or 1‑methyl‑4‑phenyl‑1,2,3,6-tetrahydropyridine (MPTP) 6 weeks. effects MPTP mice by assessing neurobehavior, neuropathology mitochondrial...
The microtubule protein inhibitor C118P shows excellent anti-breast cancer effects. However, the potential targets and mechanisms of in breast remain unknown.Real-time cellular analysis (RTCA) was used to detect cell viability. Apoptosis cycle were detected by flow cytometry. Computer docking simulations, surface plasmon resonance (SPR) technology, microscale thermophoresis (MST) conducted study interaction between alanine-serine-cysteine transporter 2 (ASCT2). Seahorse XF technology measure...
Traditional carbon-based materials suffer from fragility, low mechanical strength, and electrical conductivity when they are used as a gas diffusion layer (GDL) in proton exchange membrane fuel cells (PEMFCs), resulting power density. In this study, flexible carbon nanofiber (CFM) was studied for use GDL, prepared by polyacrylonitrile (PAN) electrospinning with the incorporation of carboxylated multiwalled nanotubes (MWCNTs), polyethylenimine (PEI) impregnation, glutaraldehyde (GA)...
Abstract Lipofectamine 2000 (Lipo2000) delivery system is commonly used for short interfering RNA (siRNA) transfection, whereas the cellular responses have attracted little attention. The purpose of this study to evaluate effect siRNA transfection using Lipo2000 on functions and possible underlying mechanism. Primary human umbilical vein endothelial cells (HUVECs) adult coronary artery cell line (HCAECs) were treated with different concentrations a Lipo2000/negative control (NC siRNA)...