We report on the generation of a femtosecond pulse in fiber ring laser by using polyvinyl alcohol (PVA)-based molybdenum disulfide (MoS2) saturable absorber (SA). With optical intensity 34 MW/cm2 and modulation depth ∼4.3%, PVA-based MoS2 SA had been employed with an erbium-doped as mode locker. The mode-locking operation could be achieved at low pump threshold 22 mW. A ∼710 fs centered 1569.5 nm wavelength repetition rate 12.09 MHz proper cavity dispersion. variation net dispersion, output...

Abstract The widespread multidrug resistance resulting from the abuse of antibiotics motivates researchers to explore alternative methods treat bacterial infections. Recently, emergence nanozymes has provided a potential approach combat bacteria. Such can mimic functions natural enzymes induce production highly toxic reactive oxygen species (ROS) as an antibacterial. However, lack effective interaction between and bacteria, intrinsic short lifetime diffusion distance ROS greatly compromise...

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment...

Tumor-derived exosomes play a pivotal role in regulating tumor progression by mediating crosstalk between cells and immune such as macrophages within the microenvironment. Macrophages can adopt two distinct polarization statuses switch M1 or M2 activation phenotypes response to different external stimuli. However, of derived macrophage phenotypic development have not been elucidated renal cell carcinoma (RCC). Here we found that high infiltration was associated with worse prognosis RCC...

Obesity, particularly increased visceral fat, positively correlates with various metabolic challenges, including atherosclerosis, but the mechanism is not fully understood. The aim of this study to determine role visceral-fat-derived exosomes (Exo) in endothelial cells and atherosclerosis. We show that obesity changes miRNA profile adipose mice. Importantly, exosomal miR-27b-3p efficiently enters into vascular activates NF-κB pathway by downregulating PPARα. Mechanistically, binds directly...

Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on...

Abstract Given that type I photosensitizers (PSs) possess a good hypoxic tolerance, developing an innovative tactic to construct PSs is crucially important, but remains challenge. Herein, we present smart molecular design strategy based on the Förster resonance energy transfer (FRET) mechanism develop photodynamic therapy (PDT) agent with encouraging amplification effect for accurate tumor therapy. Of note, benefiting from FRET effect, obtained nanostructured PDT (NanoPcSZ) boosted...

We reported on the generation of dual-wavelength rectangular pulses in a Yb-doped fiber laser (YDFL) by using microfiber-based graphene saturable absorber (GSA). The duration pulse could be varied from 1.41 ns to 4.23 with increasing pump power. With tunable bandpass filter, it was found that characteristics centered at 1061.8 nm and 1068.8 are similar each other. Moreover, switchable operation also realized properly rotating polarization controllers (PCs). demonstration YDFL would open some...

Abstract There are still huge challenges in the development of carbon dots (CDs) based long afterglow materials with multicolor emissions, especially aqueous solutions. This work reports a novel strategy achieving solution by incorporating phosphorescent CDs and fluorescent dyes into sub‐20 nm monodispersed silica nanoparticles. The matrix not only stabilizes triplet excitons but also facilitates efficient cascade Förster resonance energy transfer between donor acceptor (fluorescent dyes),...

The fibrillization and deposition of the human islet amyloid polypeptide (hIAPP) are pathological hallmark type 2 diabetes mellitus (T2DM), these insoluble fibrotic depositions hIAPP considered to strongly affect insulin secretion by inducing toxicity toward pancreatic β-cells. current strategy preventing aggregation nanoparticle-assisted inhibitors can only disassemble amyloids into more toxic oligomers and/or protofibrils. Herein, for first time, we propose a cysteine-derived chiral carbon...

Teeth staining is a common dental health challenge in many parts of the world. Traditional teeth whitening techniques often lead to enamel damage and soft tissue toxicity due use bioincompatible reagents continuous strong light irradiation. Herein, an "afterglow" photodynamic therapy (aPDT) for proposed, which realized by energy transition pathways intersystem crossing. The covalent hydrogen bonds formed carbon dots embedded silica nanoparticles (CDs@SiO2) facilitate passage through crossing...

Wound healing impairment is a dysfunction induced by hyperglycemia and its effect on endothelial precursor cells (EPCs) in type 2 diabetes mellitus. There increasing evidence showing that exosomes (Exos) derived from adipose-derived mesenchymal stem (ADSCs) exhibit the potential to improve cell function along with wound healing. However, therapeutic mechanism which ADSC Exos contribute diabetic mice remains unclear.To reveal of mice.Exos ADSCs fibroblasts were used for high-throughput RNA...

Breast cancer is the most commonly occurring and second leading cause of mortality in women. Metformin a widely prescribed anti-hyperglycemic drug, which emerging as potential preventative treatment agent. However, mechanisms underlying suppressive effects metformin on cell growth induction apoptosis are not fully elucidated. The present study aimed to identify pathways regulated by two breast lines, MDA‑MB‑231 MDA‑MB‑435. Cells were treated with various concentrations then evaluated respect...

Abstract Carbon dots (CDs) are considered as promising candidates with superior biocompatibilities for multimodel cancer theranostics. However, incorporation of exogenous components, such targeting molecules and chemo/photo therapeutic drugs, is often required to improve the efficacy. Herein, an “all‐in‐one” CDs that exhibit intrinsic bioactivities bioimaging, potent tumor therapy, postoperative management proposed. The multifunctional derived from gallic acid tyrosine (GT‐CDs) consist a...

The nonlinear mechanical behavior perception and deformation control of engineering rock masses are crucial technical challenges in the fields underground support safety monitoring. An intelligent terminal structure (ITS) rockbolts was designed for deformable systems monitoring applications. It is a type device installed at end traditional bolt. ITS comprises two key components: memory tooth yielding ring. This study introduces design principle an rockbolt systems. proposes parameters...