A5066523923- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced Photocatalysis Techniques
- Crystallography and molecular interactions
- Cancer, Hypoxia, and Metabolism
- Supramolecular Self-Assembly in Materials
- Antimicrobial Peptides and Activities
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Photochromic and Fluorescence Chemistry
- Metal complexes synthesis and properties
- Advanced X-ray and CT Imaging
- Photosynthetic Processes and Mechanisms
- Renal cell carcinoma treatment
- Medical Imaging Techniques and Applications
- Magnetism in coordination complexes
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
Fuzhou University
2016-2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Dalian Medical University
2025
Ewha Womans University
2016-2019
Hunan University
2019
State Key Laboratory of Chemobiosensing and Chemometrics
2019
Ewha Womans University Medical Center
2018
Seoul Institute
2018
Sun Yat-sen University
2015
Recent developments in the design of bifunctional and activatable photosensitizers rejuvenate aging field photodynamic sensitization therapy. While systematic studies have uncovered new dyes that can serve as potential photosensitizers, most promising results come from aimed at gaining precise control over location rate cytotoxic singlet oxygen generation. As a consequence, higher selectivities efficiencies treatment protocols are now within reach. This feature article highlights variety...
Abstract Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super‐quenched, thus, preventing use photodynamic therapy (PDT). Although some of these materials undergo stimuli‐responsive disassembly, which leads partial recovery PDT activity, therapeutic potentials unsatisfactory owing a limited ability promote generation...
Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field precision nanomedicine. Here, we develop a "one-for-all" nanomaterial that self-assembles from flexible versatile phthalocyanine building blocks. The nanostructured assemblies (NanoPcTBs) display intrinsically unique photothermal photoacoustic properties. Fluorescence reactive oxygen species generation can be triggered depending on targeted,...
We for the first time demonstrate that diversified molecular tuning approaches are available to effectively tailor phthalocyanine dyes PTT.
Albumin is a promising candidate as biomarker for potential disease diagnostics and has been extensively used drug delivery carrier decades. In these two directions, many albumin-detecting probes exogenous albumin-based nanocomposite systems have developed. However, there are only few cases demonstrating the specific interactions of with albumin in vivo, usually suffer from tedious fabrication processes toxicity complexes. Herein, we demonstrate facile "one-for-all" switchable...
Most photodynamic therapy (PDT) paradigms work through the highly O2-dependent type II photoreaction to generate singlet oxygen (1O2). The hypoxic microenvironment of solid tumors severely hampers therapeutic outcomes. Here, we present a novel design that could transfer photophysical and photochemical properties traditional phthalocyanine-based photosensitizers from efficient I vibrational relaxation-induced photothermal conversion. These features enable obtained nanostructured...
Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report facile strategy directly assemble phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) form uniform (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen...
Abstract Given that type I photosensitizers (PSs) possess a good hypoxic tolerance, developing an innovative tactic to construct PSs is crucially important, but remains challenge. Herein, we present smart molecular design strategy based on the Förster resonance energy transfer (FRET) mechanism develop photodynamic therapy (PDT) agent with encouraging amplification effect for accurate tumor therapy. Of note, benefiting from FRET effect, obtained nanostructured PDT (NanoPcSZ) boosted...
Abstract Phototherapeutic nanoplatforms that combine photodynamic therapy (PDT) and photothermal (PTT) with the guidance of photoacoustic (PA) imaging are an effective strategy for treatment tumors, but establishing a universal method this has been challenging. In study, we present supramolecular assembly based on Förster resonance energy transfer to construct nanostructured phototherapeutic agent (PcDA) via anion cation interaction between two water‐soluble phthalocyanine ramifications, PcD...
A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers.The tumor-specific activation considered to be an effective strategy for designing these photosensitizers.Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS 8 , which not photoactive under neutral conditions but precisely and efficiently activated slightly acidic environment (pH 6.5).LDH-ZnPcS prepared by using simple coprecipitation method based...
With the ever-increasing threat posed by multi-drug resistance of bacteria, development non-antibiotic agents for broad-spectrum eradication clinically prevalent superbugs remains a global challenge. Here, we demonstrate simple supramolecular self-assembly structurally defined graphene nanoribbons (GNRs) with cationic porphyrin (Pp4N) to afford unique one-dimensional wire-like GNR superstructures coated Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual-modal properties...
Abstract Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging‐guided therapy. Herein, we develop a supramolecular approach to fabricate nanostructured phototheranostic agent through the direct self‐assembly two water‐soluble phthalocyanine derivatives, PcS4 PcN4. The nature molecular recognition between PcN4 facilitates formation nanostructure (PcS4‐PcN4) consequently enables fabrication PcS4‐PcN4 with completely quenched fluorescence reduced singlet...
Abstract Trotz ihres Potentials für klinische Anwendungen besitzt die photodynamische Therapie einen entscheidenden Nachteil, der mit inhärenten Abhängigkeit von Sauerstoff einhergeht und ihre Effektivität bei Behandlung hypoxischer Tumore einschränkt. Des Weiteren befördern sowohl Sauerstoffverbrauch als auch Schädigung Mikrovaskulatur Tumorhypoxie beeinträchtigen daher den möglichen Therapieerfolg. In letzten Jahren widmeten sich zahlreiche Untersuchungen Entwicklung innovativer Methoden,...
A boronic acid functionalized phthalocyanine displays aggregation-enhanced reactive oxygen species (ROS) generation and excellent photodynamic antibacterial activity.
Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through self-assembly morpholine-substituted silicon phthalocyanine (PcM) albumin. NanoPcM displays turn-on fluorescence depending on acid-induced abolition photoinduced electron transfer effect (change molecular structure) disassembly nanostructure supramolecular structure), which enables...