A5051761504- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Sulfur Compounds in Biology
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Advanced Nanomaterials in Catalysis
- Redox biology and oxidative stress
- Nanoparticle-Based Drug Delivery
- Tactile and Sensory Interactions
- Cancer, Hypoxia, and Metabolism
- Graphene and Nanomaterials Applications
- Electron Spin Resonance Studies
- Carbon and Quantum Dots Applications
- Advanced Photocatalysis Techniques
- Extracellular vesicles in disease
- BIM and Construction Integration
- Interactive and Immersive Displays
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Photochromic and Fluorescence Chemistry
- Organoselenium and organotellurium chemistry
- Gold and Silver Nanoparticles Synthesis and Applications
Princess Margaret Cancer Centre
2023-2025
University Health Network
2023-2025
Queen's University
2025
University of Toronto
2025
Ewha Womans University
2015-2024
Ewha Womans University Medical Center
2015-2023
Baewha Women's University
2022
Seoul Institute
2019-2021
Government of the Republic of Korea
2015-2020
Kyung Hee University East-West Neo Medical Center
2009
A novel strategy for designing highly efficient and activatable photosensitizers that can effectively generate reactive oxygen species (ROS) under both normoxia hypoxia is proposed. Replacing atoms in conventional naphthalimides (RNI-O) with sulfur led to dramatic changes the photophysical properties. The remarkable fluorescence quenching (ΦPL ≈ 0) of resulting thionaphthalimides (RNI-S) suggested intersystem crossing from singlet excited state triplet was enhanced by substitution....
Abstract The ability to monitor and quantify glutathione (GSH) in live cells is essential order gain a detailed understanding of GSH‐related pathological events. However, owing their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed ratiometric probe (QG‐ 1 ) quantitatively monitoring cellular GSH. responds specifically reversibility with an ideal dissociation constant ( K d 2.59 m fast time t 1/2 =5.82 s). also...
Novel BODIPY photosensitizers were developed for imaging-guided photodynamic therapy. The introduction of a strong electron donor to the core through phenyl linker combined with twisted arrangement between and acceptor is essential reducing energy gap lowest singlet excited state triplet (ΔEST ), leading significant enhancement in intersystem crossing (ISC) BODIPYs. Remarkably, BDP-5 smallest ΔEST (ca. 0.44 eV) exhibited excellent oxygen generation capabilities both organic aqueous...
Albumin is a promising candidate as biomarker for potential disease diagnostics and has been extensively used drug delivery carrier decades. In these two directions, many albumin-detecting probes exogenous albumin-based nanocomposite systems have developed. However, there are only few cases demonstrating the specific interactions of with albumin in vivo, usually suffer from tedious fabrication processes toxicity complexes. Herein, we demonstrate facile "one-for-all" switchable...
Abstract Selective fluorescence imaging of biomarkers in vivo and situ for evaluating orthotopic hepatocellular carcinoma (HCC) chemotherapy remains a great challenge due to current agents suffering from the potential interferences other hydrolases. Herein, we observed that carbamate unit showed high selectivity toward HCC‐related biomarker carboxylesterase (CE) evaluation treatment. A near‐infrared two‐photon fluorescent probe was developed not only specially image CE activity but also...
We designed and investigated novel mitochondria-targeting heavy-atom-free BODIPY photosensitizers (R-<bold>BODs</bold>) that possessed considerable singlet oxygen generation abilities good fluorescence properties for imaging-guided photodynamic therapy (PDT).
With the ever-increasing threat posed by multi-drug resistance of bacteria, development non-antibiotic agents for broad-spectrum eradication clinically prevalent superbugs remains a global challenge. Here, we demonstrate simple supramolecular self-assembly structurally defined graphene nanoribbons (GNRs) with cationic porphyrin (Pp4N) to afford unique one-dimensional wire-like GNR superstructures coated Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual-modal properties...
Abstract Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging‐guided therapy. Herein, we develop a supramolecular approach to fabricate nanostructured phototheranostic agent through the direct self‐assembly two water‐soluble phthalocyanine derivatives, PcS4 PcN4. The nature molecular recognition between PcN4 facilitates formation nanostructure (PcS4‐PcN4) consequently enables fabrication PcS4‐PcN4 with completely quenched fluorescence reduced singlet...
Fluorescent probe 2 was designed for selectively determining mitochondria membrane potential changes. The detects changes in the a manner that is more sensitive than of commercially available indicator, Rodamine 123. As result, ideal future studies to assess functions cells.
A boronic acid functionalized phthalocyanine displays aggregation-enhanced reactive oxygen species (ROS) generation and excellent photodynamic antibacterial activity.
Abstract Trotz ihres Potentials für klinische Anwendungen besitzt die photodynamische Therapie einen entscheidenden Nachteil, der mit inhärenten Abhängigkeit von Sauerstoff einhergeht und ihre Effektivität bei Behandlung hypoxischer Tumore einschränkt. Des Weiteren befördern sowohl Sauerstoffverbrauch als auch Schädigung Mikrovaskulatur Tumorhypoxie beeinträchtigen daher den möglichen Therapieerfolg. In letzten Jahren widmeten sich zahlreiche Untersuchungen Entwicklung innovativer Methoden,...
Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through self-assembly morpholine-substituted silicon phthalocyanine (PcM) albumin. NanoPcM displays turn-on fluorescence depending on acid-induced abolition photoinduced electron transfer effect (change molecular structure) disassembly nanostructure supramolecular structure), which enables...