A5000726053- Molecular Sensors and Ion Detection
- Catalytic C–H Functionalization Methods
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- CO2 Reduction Techniques and Catalysts
- Catalytic Cross-Coupling Reactions
- Luminescence and Fluorescent Materials
- Synthesis and pharmacology of benzodiazepine derivatives
- Organic Electronics and Photovoltaics
- Antimicrobial agents and applications
- Asymmetric Synthesis and Catalysis
- Conducting polymers and applications
- Radical Photochemical Reactions
- Nanopore and Nanochannel Transport Studies
- Electrocatalysts for Energy Conversion
- Molecular Junctions and Nanostructures
- Cancer therapeutics and mechanisms
- Asymmetric Hydrogenation and Catalysis
- Organic Light-Emitting Diodes Research
- Ionic liquids properties and applications
- Antimicrobial Peptides and Activities
- Redox biology and oxidative stress
- Electrochemical Analysis and Applications
- Oxidative Organic Chemistry Reactions
- biodegradable polymer synthesis and properties
East China University of Science and Technology
2021-2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
China National Pharmaceutical Group Corporation (China)
2024
Suzhou University of Science and Technology
2023-2024
North Sichuan Medical University
2024
Liaoning University
2024
Affiliated Hospital of Guizhou Medical University
2024
Guizhou University
2023-2024
University of Florence
2024
Abstract The ability to monitor and quantify glutathione (GSH) in live cells is essential order gain a detailed understanding of GSH‐related pathological events. However, owing their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed ratiometric probe (QG‐ 1 ) quantitatively monitoring cellular GSH. responds specifically reversibility with an ideal dissociation constant ( K d 2.59 m fast time t 1/2 =5.82 s). also...
Abstract The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid precise manner is essential order alleviate serious threats humankind public security caused by unexpected terrorist attacks industrial accidents. In this investigation, we designed o ‐phenylenediamine‐pyronin linked dye that capable of both fluorogenic colorimetric discrimination between phosgene the prototypical nerve‐agent mimic, diethyl chlorophosphate (DCP) solution or gas phase....
Abstract Kharasch–Sosnovsky reaction is one of the most powerful methods for allylic oxidation alkenes. However, inherent radical mechanism and use peroxides as both oxidants oxygen nucleophiles render dearth universal catalytic systems highly enantioselective variants limited scope. Herein, an alternative to asymmetric that utilized a chiral copper catalyst purple‐LED irradiation enable three‐component coupling 1,3‐dienes, oxime esters, carboxylic acids reported. This protocol features mild...
Abstract A new strategy for fast fluorescent detection of cysteine (Cys), based on a response‐assisted electrostatic attraction, is demonstrated. By utilizing this strategy, we designed and synthesized three probes the specific Cys under actual physiological conditions. The probe m ‐ CP , coumarin fluorophore conjugated with substituted methyl pyridinium group through an unsaturated ketone unit, showed highly selective sensitive (Cys) over homocysteine (Hcy) glutathione (GSH). kinetic...
A hydrophobic core–shell architecture was constructed to control local H 2 O availability on the surface of copper-based materials, which could provide a maximum generation rate −434 mA cm −2 towards CH 4 .
Atom transfer radical addition (ATRA) reaction of alkenes has had a significant impact on the field difunctionalization alkenes. Particularly, in three-component photo-ATRA-type processes, rich chemical space and structural diversity could be achieved by smart combination redox-active precursors third coupling components (e.g., halides, C-, N-, O-nucleophiles) under mild conditions. However, inherent complicated mechanisms involving chain or outer-sphere SET incipient intermediates have led...
Electrochemical CO2 -to-CO conversion provides a possible way to address problems associated with the greenhouse effect; however, developing low-cost electrocatalysts mediate high-efficiency reduction remains challenge on account of limited understanding nature real active sites. Herein, we reveal Znδ+ metalloid sites as stable nonstoichiometric ZnOx structure derived from Zn2 P2 O7 through operando X-ray absorption fine analysis in conjunction evolutionary-algorithm-based global...
Abstract Metal-halide perovskite thin monocrystals featuring efficient carrier collection and transport capabilities are well suited for radiation detectors, yet their growth in a generic, well-controlled manner remains challenging. Here, we reveal that mass transfer is one major limiting factor during solution of monocrystals. A general approach developed to overcome synthetic limitation by using high solute flux system, which diffusion coefficient improved from 1.7×10 –10 5.4×10 m 2 s –1...
A new turn-on fluorescent probe for fast detection of cysteine in physiological conditions, based on a response-assisted electrostatic attraction strategy, is reported. The practical utility the protein labeling and subcellular imaging also demonstrated.
We design the tetraalkylammonium carboxylate-initiated superfast polymerization on α-amino acid N-carboxyanhydrides (NCA) for efficient synthesis of polypeptides. Carboxylates, as a new class initiator NCA polymerization, can initiate without need extra catalysts and be operated in open vessels at ambient condition use glove box. Tetraalkylammonium easily affords block copolymers with least 15 blocks. Moreover, this method avoids tedious purification steps enables direct crude NCAs aqueous...
Abstract Chronic osteomyelitis is a painful and serious disease normally caused by infected surgical prostheses or fractures. Currently, antibiotic‐loaded cements are extensively used as the treatment in clinical practice. However, quick emergence of antibiotic‐resistant bacteria has resulted formidable challenge treating chronic osteomyelitis, such methicillin‐resistant Staphylococcus aureus (MRSA). Aiming to address MRSA‐infected an antibacterial peptide polymer doped...
It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices. Host defense peptide-mimicking polymers have been actively explored in recent years fight against drug-resistant microbes. Our report on lithium hexamethyldisilazide-initiated superfast polymerization amino acid N-carboxyanhydrides enables the quick synthesis of host peptide polymers. Here we reported a facile and cost-effective thermoplastic polyurethane (TPU) surface...
Abstract Objectives In the current study, for first time, we reported a novel HCV molecular diagnostic approach termed reverse transcription loop-mediated isothermal amplification integrated with gold nanoparticles-based lateral flow biosensor (RT-LAMP-AuNPs-LFB), which developed rapid, sensitive, specific, simple, and visual identification of HCV. Methods A set LAMP primer was designed according to 5’untranslated region (5’UTR) gene from major genotypes 1b, 2a, 3b, 6a, 3a, are prevalent in...
A new fluorescent probe with a unique sequential dual FRET process was designed and constructed. This showed distinguished responses towards Fe(3+) Hg(2+), making it an ideal candidate for multiple logic operations at the molecular level.
Abstract The ability to monitor and quantify glutathione (GSH) in live cells is essential order gain a detailed understanding of GSH‐related pathological events. However, owing their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed ratiometric probe (QG‐ 1 ) quantitatively monitoring cellular GSH. responds specifically reversibility with an ideal dissociation constant ( K d 2.59 m fast time t 1/2 =5.82 s). also...
Dopamine (DA) is an important neurotransmitter, which not only participates in the regulation of neural processes but also plays critical roles tumor progression and immunity. However, direct identification DA-containing exosomes, as well quantification DA single vesicles, still challenging. Here, we report a nanopipette-assisted method to detect exosomes their dopamine contents via amperometric measurement. The resistive-pulse current measured can simultaneously provide accurate information...
An efficient method for the enantioselective construction of tertiary 1,3-diols via Pd-catalyzed asymmetric allylic cycloaddition vinyloxetanes with an abundant feedstock, formaldehyde, is developed. Using palladium complex generated in situ from Pd2(dba)3·CHCl3 and phosphoramidite L3 as a catalyst under mild conditions, process allows one to convert racemic 2-substituted 2-vinyloxetanes (1) corresponding 1,3-dioxanes (2) methylene acetal protected high yields good excellent enantioselectivities.
Abstract In this paper, bimetallic sulfide Co 9 S 8 /N−C@MoS 2 dodecahedral heterogeneous nanocages (DHNCs) are designed and synthesized via pyrolysis sulfidation. The DHNCs with unique structure composition display superior lithium storage performance (a reversible capacity of approximate 557 mA h g −1 at 5 A after 400 cycles) potassium about 100 1 cycles). remarkable electrochemical properties attributed to the synergistic effect sulfides special polyhedral hollow conductive N‐doped...
A new water-soluble receptor 1 has been synthesized and it showed selective recognition of zwitterionic arginine in aqueous media. Moreover, the could be regard as a facile tool for protein labeling quantitative determination (LOD = 15 nM).
Pd-catalyzed regio- and enantioselective allylic etherification of vinylethylene carbonates (VECs) with diols has been developed. By using cooperative catalysts the chiral palladium complex triethylborane in mild conditions, process gave monoetherified bisetherified polyglycol derivatives tetrasubstituted stereocenters high yields complete regioselectivities levels enantio- diastereoselectivities.