Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment...

Abstract Abnormal tumor metabolism causes the hypoxic microenvironment, which greatly limits efficacy of photodynamic therapy (PDT). In this work, a strategy metabolic reprogramming is proposed to economize O 2 for enhanced PDT against tumors. The carrier‐free ‐economizer (designated as LonCe) prepared based on antitumor drug Lonidamine (Lon) and photosensitizer chlorin e6 (Ce6). By virtue intermolecular interactions, Lon Ce6 self‐assemble into nanosized LonCe with favorable stability high...

Inflammation activation is accompanied by tumor growth, migration, and differentiation. Photodynamic therapy (PDT) can trigger an inflammatory response to cause negative feedback of inhibition. In this paper, a feedback-elevated antitumor amplifier developed constructing self-delivery nanomedicine for PDT cascade anti-inflammation therapy. Based on the photosensitizer chlorin e6 (Ce6) COX-2 inhibitor indomethacin (Indo), prepared via molecular self-assembly technology without additional drug...

Abstract Malignant proliferation of tumor cells induces abnormal tissue microenvironments, leading to therapeutic resistance and poor outcome. In this paper, manganese dioxide (MnO 2 ) nanoshells are coated on a porphyrinic metal–organic framework porous coordination network (PCN)‐224 for doxorubicin (DOX) loading hyaluronic acid (HA) modification obtain an intelligent nanoplatform PCN@MnO @DOX@HA (PMDH). Benefiting from the HA functionalization, PMDH prefers accumulate in sites enhance...

A chlorine e6 and curcumin based self-delivery nanomedicine is prepared to inhibit the TrxR activity for chemotherapy sensitized photodynamic therapy.

Antioxidant-defense systems of tumor cells protect them from oxidative damage. Herein, a carrier-free nanomedicine is developed based on chlorine e6 (Ce6) and coniferyl ferulate (Con), which inhibits glutathione S-transferase (GST) activity to hamper antioxidant amplify intracellular stress for enhanced photodynamic therapy.

As a critical regulator of tumor proliferation, the mTOR pathway could enhance growth, metabolism, and metastasis numerous malignant tumors, which would weaken antitumor effect photodynamic therapy (PDT). Herein, we conceived pure-drug-assembled nanomedicine (named CeBez) only comprised photosensitizer chlorine e6 (Ce6) Bez235 (Bez) for chemo-/photodynamic therapy. Bez, potent inhibitor PI3K/AKT/mTOR targeting both PI3K mTOR, specifically downregulate to achieve chemotherapy. CeBez exhibited...

Tumor cells activate DNA repair pathways to combat the oxidative damage induced by reactive oxygen species (ROS), contributing their resistance photodynamic therapy (PDT). Herein, a self-delivery sensitizer is developed enhance blocking pathway through poly(ADP-ribose) polymerase (PARP) inhibition. Specifically, (CeOla) constructed based on self-assembly of photosensitizer chlorine e6 (Ce6) and PARP inhibitor olaparib (Ola). Of note that carrier free CeOla has high drug content favorable...

Oxygen-dependent photodynamic therapy (PDT) could exacerbate tumor hypoxia to induce the upregulation of hypoxia-inducible factor-1α (HIF-1α), which would promote growth and metastasis. In this paper, a self-remedied nanomedicine is developed based on photosensitizer HIF-1α inhibitor surmount Achilles' heel PDT for enhanced antitumor efficacy. Specifically, (designated as CYC-1) prepared by self-assembly chlorine e6 (Ce6) 3-(5′-hydroxy-methyl-2′-furyl)-1-benzylindazole (YC-1) through π–π...

Hypoxia is a common feature for most malignant tumors, which was also closely related to the oxygen-dependent photodynamic therapy. Based on Förster resonance energy transfer (FRET), smart nanoprobe (designated as H-Probe) designed in this paper hypoxia imaging and tumor Due FRET process, H-Probe could respond with significant fluorescence recovery. Moreover, abundant vitro investigations demonstrated that photosensitizer of PpIX generate large amounts singlet oxygen kill cancer cells...

Cronartium species (Basidiomycota, Pucciniales, Melampsorineae) infect two or five-needle pines, resulting in considerable economic losses and ecological damage.Many are considered of quarantine importance, however, precise identification is challenging due to the poorly resolved generic boundaries other members Melampsorineae, as well limits within genus Cronartium.In this study, delimitation was carried out based on morphological examination multi-locus phylogenetic assessment using...

Abstract Oxygen‐dependent photodynamic therapy (PDT) holds unique advantages on tumor treatment by inducing cell apoptosis, but it is often limited owing to the unfavorable microenvironments. In this study, a self‐delivery O 2 ‐ecomonizer (designated as CeTam) prepared relieve hypoxia and reverse antiapoptotic pathway for enhanced therapy. Based Chlorin e6 (Ce6) Tamoxifen (Tam), CeTam assembled through intermolecular hydrophobic interaction without any vehicles. Nanosized has an stability...

Objective: To analyze the genetic mutations and clinical features of subtypes classical BCR-ABL-negative myeloproliferative neoplasm (MPN) . Methods: Mutations 108 newly diagnosed MPN patients [including 55 with essential thrombocytopenia (ET) , 24 polycythemia vera (PV) 29 primary myelofibrosis (PMF) ] were identified using next-generation sequencing 127-gene panel, relationship between gene analyzed. Results: Total 211 in 32 genes detected 100 (92.59% ) per capita carried (1.96±1.32)...

Mammalian DNA derived from invertebrates (iDNA), including blowfly iDNA, is an alternative tool to conventional camera trapping in assessing mammalian diversity. The method has been used tropical mammal surveillance but no attempt made compare the efficacy of iDNA and for monitoring diversity subtropical forests. We compared with assess Jiulongfeng Nature Reserve (JLF), China, over a one-month period. traps captured 2508 animal photos 11 species belonging four orders, eight genera, families,...

Abstract A carbonate oilfield in the Middle East carries out mixed water injection of produced and fresh water, after 1 year its rapid exploration. The injected is highly corrosive, with high salinity, chloride concentration hydrogen sulfide. Recently, there are dozens corrosion perforations on L80 tubing injectors within 2 years field rate reaches 3.6 mm/a. After leaks, enters into annulus between casing, which causes casing corrosion, damages well integrity, greatly influences production....

Abstract Background: Photodynamic therapy (PDT) has been recognized as a promising tumor treatment for its minimal invasiveness, low side effects and on-demand light controllability. However, the oxygen-dependent PDT could exacerbate hypoxia to upregulate expression of hypoxia-inducible factor-1α (HIF-1α), which would promote growth metastasis. Inhibition HIF-1α activity is very necessary effective suppression. Results: Herein, we developed self-remedied nanomedicine based on photosensitizer...