A5036334377- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Neonatal Respiratory Health Research
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- Photosynthetic Processes and Mechanisms
- Hemodynamic Monitoring and Therapy
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- Forest ecology and management
- Plant Water Relations and Carbon Dynamics
- Plant Molecular Biology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Hydrogels: synthesis, properties, applications
- Mechanical Circulatory Support Devices
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Conditions and Treatments
Wuhan University
2015-2025
Shenyang Agricultural University
2019-2025
Southern Medical University
2023-2024
Guangdong Academy of Medical Sciences
2014-2024
Guangdong Provincial People's Hospital
2020-2024
Zigong First People's Hospital
2024
Zhejiang Chinese Medical University
2020-2023
Liaoning Academy of Agricultural Sciences
2023
Huaibei Normal University
2023
Peking University
2021-2023
Pyroptosis is a lytic and inflammatory form of programmed cell death could be induced by chemotherapy drugs via caspase-3 mediation. However, the key protein gasdermin E (GSDME, translated DFNA5 gene) during caspase-3-mediated pyroptosis process absent in most tumor cells because hypermethylation (deafness autosomal dominant 5) gene. Here, we develop strategy combining decitabine (DAC) with nanodrugs to trigger epigenetics, further enhancing immunological effect chemotherapy. DAC...
Natural nanoparticles have been extensively studied due to their diverse properties and easy accessibility. Here, the extracted from cuttlefish ink (CINPs) with significant antitumor efficacy are explored. These CINPs, spherical morphology, good dispersibility, biocompatibility, rich in melanin contain a variety of amino acids monosaccharides. Through activation mitogen-activated protein kinase (MAPK) signaling pathway, CINPs can efficiently reprogram tumor-associated macrophages (TAMs)...
Abstract Surface modification of nanomaterials is essential for their biomedical applications owing to passive immune clearance and damage reticuloendothelial systems. Recently, a cell membrane‐coating technology has been proposed as an ideal approach modify its facile functionalized process good biocompatibility improving performances synthetic nanomaterials. Here, recent advances membrane‐coated are reviewed based on the main biological functions membrane in living cells. An overview...
Developing appropriate photothermal agents to meet complex clinical demands is an urgent challenge for therapy of tumors. Here, platinum-doped Prussian blue (PtPB) nanozymes with tunable spectral absorption, high conversion efficiency, and good antioxidative catalytic activity are developed by one-step reduction. By controlling the doping ratio, PtPB exhibit localized surface plasmon resonance (LSPR) frequency significantly enhanced efficiency allow multiwavelength photoacoustic/infrared...
As an emerging cancer treatment strategy, ferroptosis is greatly restricted by excessive glutathione (GSH) in tumor microenvironment (TME) and low reactive oxygen species (ROS) generation efficiency. Here, this work designs self-assembled copper-alanine nanoparticles (CACG) loaded with glucose oxidase (GOx) cinnamaldehyde (Cin) for situ activated enzymatic cascade-enhanced immunotherapy. In response to GSH-rich acidic TME, CACG allows effectively co-deliver Cu2+ , Cin, GOx into tumors....
Quaternized celluloses (QCs) were homogeneously synthesized by reacting cellulose with 3-chloro-2-hydroxypropyltrimethylammonium chloride (CHPTAC) in NaOH/urea aqueous solutions. The structure and solution properties of the QCs characterized using elemental analysis, FTIR, 13C NMR, SEC-LLS, viscometer, ζ-potential measurement. results revealed that water-soluble QCs, a degree substitution (DS) value 0.20−0.63, could be obtained adjusting molar ratio CHPTAC to anhydroglucose unit (AGU)...
In this paper, an intracellular glutathione (GSH) responsive mesoporous silica nanoparticle (MSN-S-S-RGD) was developed as a drug nanocarrier by immobilizing the gatekeeper (RGD containing peptide) onto MSNs using disulfide bonds. The antitumor drug, DOX loaded porous structure of and DOX@MSN-S-S-RGD system has been proved to be effective nanocarrier. It determined that most could entrapped with only slight leakage. After being accumulated in tumor cells via receptor-mediated endocytosis,...
Hydrogels with pH-sensitive poly(acrylic acid) (PAAc) chains and biodegradable acryloyl−poly(ϵ-caprolactone)−2-hydroxylethyl methacrylate (AC-PCL-HEMA) were designed synthesized. The morphology of hydrogel was observed by scanning electron microscopy. degradation the in presence Pseudomonas lipase studied. vitro release bovine serum albumin from investigated. Cytotoxicity study shows that AC-PCL-HEMA/AAc copolymer exhibits good biocompatibility. Cell adhesion migration into networks...
Activatable photosensitizers (aPSs) have emerged as promising photodynamic therapy (PDT) agents for simultaneous imaging and selective ablation of cancer. However, traditional synthetic aPSs are limited by complex design tedious synthesis. Here, aPS regulated cucurbit[8]uril (CB[8]) targeted cancer PDT is reported. This system based on the host–guest interaction between biotinylated toluidine blue (TB-B) CB[8] to form 2TB-B@CB[8]. Moreover, a facile strategy turn off/on fluorescence activity...
Abstract Keratins extracted from human hair have emerged as a promising biomaterial for various biomedical applications, partly due to their wide availability, low cost, minimal immune response, and the potential engineer autologous tissue constructs. However, fabrication of keratin‐based scaffolds typically relies on limited crosslinking mechanisms, such via physical interactions or disulfide bond formation, which are time‐consuming result in relatively poor mechanical strength stability....
Tumor cells adapt to reactive oxygen species (ROS) attacking by launching DNA damage repairing mechanisms such as nucleotide pool sanitizing enzyme mutt homologue 1 (MTH1) mitigate the oxidatively induced lesions, which could greatly limit therapeutic efficiency of current oxidation therapy. Here, an amplified oxidative strategy for tumor therapy was proposed that focused not only on enhancement ROS generation but also inhibition subsequent MTH1 activity simultaneously. In our formulation,...
Abstract Traditional phototherapies face the issue that insufficient penetration of light means it is difficult to reach deep lesions, which greatly reduces feasibility cancer therapy. Here, an implantable nitric oxide (NO)‐release device developed achieve long‐term, long‐distance, remote‐controllable gas therapy for cancer. The consists a wirelessly powered light‐emitting diode (wLED) and S‐nitrosoglutathione encapsulated with poly(dimethylsiloxane) (PDMS), obtaining NO‐release wLED...
A dark/light relay strategy based on a remote-controllable multi-enzyme system was proposed to kill tumor cells upon light irradiation.
Abstract Cancer cells, with unique their metabolism, frequently exhibit a high level of redox homeostasis, which could be feasible target for cancer treatment. Here, liquid metal (LM) nanoparticles are used as template to guide the growth yolk‐shell structured LM@MnO 2 (LMN). With structures, LMNs is applied load cinnamaldehyde (CA) (CLMN) and further coated hyaluronic acid (HA) construct CA&LM@MnO ‐HA nanoflowers (CLMNF) targeted Owing urchin‐like shell, it found that obtained CLMNF...
Therapies based on stem cells have shown very attractive potential in many clinical studies. However, the data about safety of application remains insufficient. The present study was designed to evaluate overall toxicology human umbilical cord mesenchymal (hUC-MSCs) cynomolgus monkeys with repeated administrations. hUC-MSCs were administered by intravenous injection once every 2 weeks for 6 weeks. dose levels employed this 2×106, 1×107 cells/kg body weight. Toxicity evaluated observations...