A5081380883- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- Heme Oxygenase-1 and Carbon Monoxide
- Click Chemistry and Applications
- Molecular Sensors and Ion Detection
- TGF-β signaling in diseases
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Ferroelectric and Piezoelectric Materials
- Neonatal Health and Biochemistry
- Cancer Cells and Metastasis
- Electronic and Structural Properties of Oxides
- Extracellular vesicles in disease
- Robotics and Sensor-Based Localization
- Analytical Chemistry and Sensors
- Cancer, Hypoxia, and Metabolism
- Metal and Thin Film Mechanics
- HER2/EGFR in Cancer Research
- High-Temperature Coating Behaviors
- Microwave Dielectric Ceramics Synthesis
Affiliated Hospital of North Sichuan Medical College
2025
China Pharmaceutical University
2018-2025
Northeastern University
2024
The University of Texas Health Science Center at Houston
2024
Wuhan University
2013-2021
State Key Laboratory of Natural Medicine
2019
Ministry of Education
2016
Shanghai Institutes for Biological Sciences
2012-2016
Shanghai Jiao Tong University
2009-2016
Chinese Academy of Sciences
2012-2016
A multifunctional prodrug, designated as TPP‐L‐GEM, is fabricated to realize image‐guided in situ tumor photodynamic therapy (PDT) with red light activatable chemotherapy. Gemcitabine conjugated a fluorescent photosensitizer, meso‐tetraphenylporphyrin (TPP), by reactive oxygen species cleavable thioketal linker. Under the irradiation of low‐energy light, TPP can generate singlet and damage cells therapy. Simultaneously, linkage be cleaved result cascaded gemcitabine release, causing...
In this paper, mesoporous silica nanoparticle (MSN) loaded with doxorubicin (DOX) and capped tumor-homing/-penetrating peptide tLyP-1-modified tungsten disulfide quantum dots (WS2-HP) was designed applied as a stimuli-responsive "Cluster Bomb" for high-performance tumor suppression. The tLyP-1 on the surface can both facilitate homing of DOX@MSN-WS2-HP to 4T1 greatly enhance penetration WS2-HP in tumor. benzoic-imine bonds linkers between "bomblets" "dispenser" are stable under normal...
Exosomes derived from tumor cells are essential for processes involved in progression, including angiogenesis, cell proliferation and immunoregulation. In addition, exosome secretion may contribute to the mechanisms of hypoxia-induced angiogenesis metastasis tumors. present study, as it is one most common cancers females, breast cancer, lines were cultured under hypoxic (1% O2) normoxic conditions evaluate effects hypoxia on production. Under an increase number exosomes medium, determined by...
The application of functional genomic analysis breast cancer metastasis has led to the identification a growing number organ-specific genes, which often function in concert facilitate different steps metastatic cascade. However, gene regulatory network that controls expression these genes remains largely unknown. Here, we demonstrate computational approach for deconvolution transcriptional networks discover master regulators bone metastasis. Several known such as Smad4 and HIF1 were...
Abstract The transforming growth factor β (TGFβ) pathway plays critical roles during cancer cell epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional target negative regulator of TGFβ signalling, thus mediating feedback loop that may potentially restrain responses cells. Here, however, we show treatment induces transcription but not its protein level in panel Mechanistic studies reveal activates the expression microRNA-182 (miR-182), which suppresses...
Carbon monoxide (CO) is regarded as a potential therapeutic agent with multiple beneficial functions for biomedical applications. In this study, versatile CO nanogenerator (designated PPOSD) was fabricated and developed tumor therapy anti-inflammation. Partially oxidized tin disulfide (SnS2) nanosheets (POS NSs) were decorated tumor-targeting polymer (polyethylene glycol-cyclo(Asp-d-Phe-Lys-Arg-Gly), PEG-cRGD), followed by the loading of chemotherapeutic drug doxorubicin (DOX) to prepare...
Fighting metastasis is a major challenge in cancer therapy, and stimulation of the immune system particular importance treatment metastatic cancers. Here, an integrated theranostic nanoplatform was developed for efficient highly tumors. Versatile functions including "And" logically controlled drug release, prolonged circulation time, tumor targeting, anti-metastasis were into doxorubicin (DOX) loaded, mesoporous silica nanoparticles (DOX@HIMSNs) systemic triple negative breast (TNBC). It...
A novel cancer targeting and pH-responsive prodrug was successfully designed synthesized. This M-prodrug demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin a coumarin derivative.
Mesoporous silica nanoparticles (MSNs) have proved to be an effective carrier for controlled drug release and can functionalized easily use as stimuli-responsive vehicles. Here, a novel intelligent drug-delivery system (DDS), camptothecin (CPT)-loaded doxorubicin (DOX)-conjugated MSN (CPT@MSN-hyd-DOX), is reported via facile one-pot preparation in synergistic chemotherapy of glioblastoma. DOX was conjugated MSNs acid-labile hydrazone bonds, CPT loaded the pores MSNs. At pH 6.5 (analogous...
A dual-Förster resonance energy transfer (FRET)-based versatile prodrug (V-prodrug), in which the fluorescence of both 5(6)-carboxylfluorescein (FAM) and doxorubicin (DOX) can be quenched by 4-(dimethylaminoazo)benzene-4-carboxylic acid (Dabcyl) with high quenching efficiency, is developed this paper. The V-prodrug selectively bind to αvβ3 integrin overexpressed cancer cells through Arg-Gly-Asp (RGD) targeting moiety. After that, acid-mediated DOX release real-time monitored increase red...
Bone metastasis is a frequent complication of breast cancer that often accelerated by TGF-β signaling; however, little known about how the pathway regulated during bone metastasis. Here we report deleted in liver 1 (DLC1) an important regulator responses and osteolytic cells. In murine models, cells lacking DLC1 expression exhibited enhanced capabilities Knockdown promoted metastasis, leading to manifested osteolysis death mice, while overexpression suppressed Activation Rho-ROCK signaling...
Graphene oxide (GO)‐based theranostic nanohybrid is designed for tumor induced imaging and potential combinational therapy. The anti‐tumor drug, Doxorubicin (DOX) chemically conjugated to the poly(ethylenimine)‐co‐poly(ethylene glycol) (PEI‐PEG) grafted GO via a MMP2‐cleavable PLGLAG peptide linkage. therapeutic efficacy of DOX locked its intrinsic fluorescence quenched by under normal physiological condition. Once stimulated MMP2 enzyme over‐expressed in tissues, resulting cleavage permits...
A dark/light relay strategy based on a remote-controllable multi-enzyme system was proposed to kill tumor cells upon light irradiation.
In this paper, a novel stepwise-acid-active multifunctional mesoporous silica nanoparticle (MSN-SATAT&DMAK11) was developed as drug carrier. The MSN-SATAT&DMAK11 is able to reverse its surface charge from negative positive in the mildly acidic tumor extracellular environment. Then, fast endo/lysosomal escape and subsequent nucleus targeting well intranuclear release can be realized after cellular internalization. Because of difference acidity between environment that endo/lysosomes, exhibits...