A5057100472- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Drug Transport and Resistance Mechanisms
- Advancements in Transdermal Drug Delivery
- Graphene and Nanomaterials Applications
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Drug Solubulity and Delivery Systems
- Advanced Nanomaterials in Catalysis
- Bone health and treatments
- Estrogen and related hormone effects
- Peptidase Inhibition and Analysis
- Proteins in Food Systems
- Protein Degradation and Inhibitors
- Photodynamic Therapy Research Studies
- Inflammasome and immune disorders
China Pharmaceutical University
2015-2024
State Key Laboratory of Natural Medicine
2015-2022
State Key Laboratory of Natural and Biomimetic Drugs
2019
Peking University
2019
Advanced Pharma
2018
657 Oslo
2014
Abstract A new synergistic treatment that combines photothermal therapy (PTT) and inflammation‐mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the tumor ablation accompanied by an inflammatory effect upregulation of factors at site, which may accelerate regeneration. Moreover, PTT‐induced inflammation can also recruit neutrophils (NEs) to site. To convert disadvantages into strengths, NEs are investigated as for IMAT further inhibit...
A novel "collaborative assembly" approach was reported for the synthesis of an siRNA delivery system via a combination electrostatically driven physical assembly and facile click reaction-mediated chemical assembly, which showed various advantages more safety, efficiency, flexibility over conventional that is only based on assembly. This strategy remained high cationic property lipid-based complex loading capacity. The direct modification model polyanion, hyaluronic acid (HA) chemistry...
In this study, a dual-targeting drug delivery system based on bovine serum albumin nanoparticles (BSA-NPs) modified with both lactoferrin (Lf) and mPEG2000 loading doxorubicin (DOX) was designed, its blood–brain barrier (BBB) penetration brain glioma cells targeting properties were explored. BSA-NPs prepared by desolvation technique, incorporated onto the surface of reacting free amino-group BSA to form mPEG2000-modified (P2000-NPs). Finally, Lf-modified P2000-NPs (Lf-NPs) obtained absorbing...
Multifunctional nanomedicines with active targeting and stimuli-responsive drug release function utilizing pathophysiological features of the disease are regarded as an effective strategy for treatment rheumatoid arthritis (RA). Under inflammatory environment RA, activated macrophages revealed increased expression folate receptor elevated intracellular reactive oxygen species (ROS) level. In this study, we successfully conjugated to polyethylene glycol 100 monostearate film-forming material...
A new conjugate, octreotide-polyethylene glycol(100) monostearate (OPMS), was developed for the enhancement of targeting delivery hydroxycamptothecine (HCPT) loaded in nanostructured lipid carrier (NLC). 2 × 10(-3) and 5 mmol OPMS were respectively used to modify NLC so that targeted nanocarriers with low high ligand density obtained. For comparison, pegylated NLCs without octreotide prepared by adding equal molar amounts polyethylene (PGMS). The relation between modification levels...
Abstract A multimodal cancer therapeutic nanoplatform is reported. It demonstrates a promising approach to synergistically regulating the tumor microenvironment. The combination of intracellular reactive oxygen species (ROS) generated by irradiation photosensitizer and endoplasmic reticulum (ER) stress induced 2‐deoxy‐glucose (2‐DG) has profound effect on necrotic or apoptotic cell death. Especially, targeting metabolic pathway 2‐DG strategy promote photodynamic therapy chemotherapy. can...
Cholesterol crystals (CCs), originally accumulating in the lysosome of cholesterol-laden cells, can aggravate progression atherosclerosis. β-cyclodextrin (CD) is a potent cholesterol acceptor or CC solubilizer. However, random extraction impedes vivo application CD for removing lysosomal CCs. Here, we exploit poly-β-cyclodextrin (pCD) as solubilizer and dextran sulfate grafted with benzimidazole (BM) pH-sensitive switch (pBM) to self-assemble into supramolecular nanoassembly (pCD/pBM-SNA)....
Octreotide is believed to be the ligand of somatostatin receptors (SSTRs) which are widely used in tumor diagnosis and clinical therapy. In present work, a new targeting conjugate, octreotide-polyethylene glycol-phosphatidylethanolamine (Oct-PEG-PE), was developed for assembling liposome, effect octreotide-modification on enhancement delivery doxorubicin-loaded liposomes investigated vitro vivo. Oct-PEG-PE synthesized by three-step reaction involving two derivative intermediate formations...
Given the multiple interactions between neutrophils (NEs) and atherosclerosis (AS), in this study, we exploited NEs as cellular vehicles loaded with cationic liposomes for actively targeting atherosclerotic sites. The based on possess efficient internalization of sensitive response to chemotaxis inflammatory cells, which ultimately realize targeted delivery cargos into target cells vitro. Moreover, these effects also translated significant enhancement accumulation NEs' plaque vivo after...
Multidrug resistance (MDR) due to P-glycoprotein (P-gp) overexpression is a major obstacle successful leukemia chemotherapy. The combination of anticancer chemotherapy with chemosensitizer P-gp inhibitor promising overcome MDR, generate synergistic effects, and maximize the treatment effect. Herein, we co-encapsulated chemotherapeutic drug mitoxantrone (MTO) β-elemene (βE) in solid lipid nanoparticles (MTO/βE-SLNs) for reversing MDR leukemia. MTO/βE-SLNs about 120 nm particle size possessed...
Limb and CNS expressed 1 like (LIX1L) is over-expressed in several types of tumors. However, the function LIX1L glucose metabolism hepatocellular carcinoma (HCC) progression remains elusive. Here we report that human HCC tissues, which predicts unfavorable prognosis. deficiency vivo significantly attenuated liver cancer initiation mice. Functional studies indicated overexpression elevated proliferation, migratory, invasive capacities cells vitro, promoted growth metastasis vivo. knockdown...