A5060608811- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Lipid Membrane Structure and Behavior
- Advanced Drug Delivery Systems
- Epigenetics and DNA Methylation
- Dendrimers and Hyperbranched Polymers
- Advanced Nanomaterials in Catalysis
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Photodynamic Therapy Research Studies
- Phagocytosis and Immune Regulation
- Ginseng Biological Effects and Applications
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
- Luminescence and Fluorescent Materials
- Drug Solubulity and Delivery Systems
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
China Pharmaceutical University
2016-2025
Anhui Provincial Hospital
2021-2025
Nanjing Drum Tower Hospital
2022
State Key Laboratory of Natural Medicine
2017
Abstract Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths. Near-infrared dye IR-780 could be used as photosensitizer both for PTT PDT, but its lipophilicity limits practical use in vivo efficiency. Herein, a simple multifunctional IR780-loaded nanoplatform based on transferrin was developed targeted imaging phototherapy cancer...
Nanozymes as artificial enzymes that mimicked natural enzyme-like activities have received great attention in cancer diagnosis and therapy. Biomimetic nanozymes require more consideration regarding complicated tumor microenvironments to mimic biological enzymes, thus achieving superior nanozyme activity vivo. Here we report a biomimetic hybrid (named rMGB) which integrates enzyme glucose oxidase (GOx) with manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic of MnO2 GOx....
The high redox level of tumor microenvironment inhibits the oxidation treatment and immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmenting photothermal immunotherapy breast cancer. ML effectively depletes intracellular GSH up-regulates reactive oxygen species (ROS) in both DCs. In cells, ROS boosted ABTS·+ production activate...
CXCR4 antagonistic nanocomplex regulates the immune process to enhance anti–PD-L1 immunotherapy.
The abundant glutathione (GSH) in "cold" tumors weakens ferroptosis therapy and the immune response. Inspired by lipids, we fabricated cinnamaldehyde dimers (CDC) into lipid-like materials to form dimersomes capable of depleting GSH delivering therapeutics potentiate immunotherapy breast cancer. exhibited superior storage stability for over one year. After reaching tumor, they quickly underwent breakage cytosol owing conjugation hydrophilic on CDC Michael addition, which not only triggered...
Abstract Protein‐based theranostic agents (PBTAs) exhibit superior performance in the diagnosis and therapy of cancers. However, vivo applications PBTA are largely limited by undesired accumulation, penetration, or selectivity. Here, an ATP‐supersensitive protein cluster is fabricated for promoting delivery enhancing magnetic resonance imaging (MRI)‐guided tumor photothermal therapy. Gd 3+ ‐ CuS‐coloaded small bovine serum albumin nanoparticles (GdCuB) synthesized as model with a size 9 nm...
This study introduces a novel cross-linking strategy capable of successfully stabilizing CaP nanoparticles and stimuli-responsive small interfering RNA (siRNA) release. We synthesized polysaccharide derivative thiolated hyaluronic acid (HA-SH), which was slightly modified but multifunctional developed smart redox-responsive delivery system. siRNA efficaciously condensed by calcium phosphate (CaP) via electrostatic interaction to form positively charged inner "core". Disulfide cross-linked HA...
Abstract Poor antigenic presentation of tumor tissues and a lack specific targets currently limit the success nanoparticle delivery system. Cellular carrier technique has been recently explored extensively as substitutive or supplement for traditional targeting Here, we demonstrate usage mesenchymal stem cells (MSCs) loaded with doxorubicin containing polymer nanoparticles in pulmonary melanoma metastases therapy, modified targeted The characterizations prepared MSCs sensitivity to DOX...
Photodynamic therapy relies on photosensitizers to generate cytotoxic reactive oxygen species (ROS) resulting in the apoptois of tumor cells. However, there is an antioxidant system that impedes elevation oxidation levels Thus, photodynamic may exhibit insufficient curative effects due ungenerous levels. Herein, we describe tumor-specific activated using oxidation-regulating strategy. Methods: We first synthesised a species-sensitive amphipathic prodrug gambogic acid-grafted hyaluronic acid...
The unsatisfied results of cancer therapy are caused by many issues and metastasis cells is one the major challenge. It has been reported that inhibiting SDF1/CXCR4 interaction can significantly reduce breast to regional lymph nodes lung. Herein, a nanogel system equipped with FDA-approved CXCR4 antagonist AMD3100 was developed evaluated for its combined antimetastatic tumor targeting effects. Briefly, bioreducible cross-linked dextrin (DNG) coated designed possess multiple functions,...
Clinical investigations have shown that a nonimmunogenic "cold" tumor is usually accompanied by few immunopositive cells and more immunosuppressive in the microenvironment (TME), which still bottleneck of immune activation. Here, fluorine assembly nanocluster was explored to break shackles immunosuppression, reawaken system, turn cold "hot." Once under laser irradiation, FS@PMPt produces sufficient reactive oxygen species (ROS) fracture ROS-sensitive linker, thus releasing cisplatin...
Development of T1/T2 dual-mode MRI contrast agents that can also treat cancer is an attractive prospect for personalized precision medicine. Unfortunately, conventional suffer from toxicity and lack any ability to cancer. An all-iron MR imaging agent with photothermal drug delivery capability would overcome these issues. Here, avocado-like Fe3+/Fe2O3 composed T1-T2 based on Fe-TA coordination network (CNMN) developed. This material possesses suitable longitudinal transverse relaxation...
Tumor-associated macrophages (TAMs) play a crucial part in cancer evolution. Dynamic imaging of TAMs is great significance for treatment outcome evaluation and precision tumor therapy. Currently, most fluorescence nanoprobes tend to accumulate the liver are difficult metabolize, which leads strong background signals inadequate quality nearby such as pancreatic cancer. Herein, we aim develop metabolizable dextran-indocyanine green (DN-ICG) second near-infrared window (NIR-II, 1 000-1 700 nm)...
Acquired drug resistance and epithelial-mesenchymal transition (EMT) mediated metastasis are two highly interacting determinants for non-small-cell lung cancer (NSCLC) prognosis. This study investigated the common mechanisms of EMT from perspective metabolic reprogramming, which may offer new ideas to improve anticancer therapy. resistant cells were found grow faster have a greater migratory invasive capacity than their parent cells. Metabolomics analysis revealed that acquired relied on...