A5100434026- Nanoplatforms for cancer theranostics
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Advanced NMR Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Atomic and Subatomic Physics Research
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Medical Imaging Techniques and Applications
- Extracellular vesicles in disease
- Advanced Proteomics Techniques and Applications
- Magnetism in coordination complexes
- Advanced Photocatalysis Techniques
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Liquid Crystal Research Advancements
- Electron Spin Resonance Studies
- Hydrocarbon exploration and reservoir analysis
- Methane Hydrates and Related Phenomena
- Advanced X-ray Imaging Techniques
- Synthetic Aperture Radar (SAR) Applications and Techniques
Chinese Academy of Sciences
2016-2025
Wuhan Institute of Physics and Mathematics
2022-2025
Wuhan National Laboratory for Optoelectronics
2013-2025
University of Chinese Academy of Sciences
2010-2025
Northwest Normal University
2025
Huazhong University of Science and Technology
2010-2025
Tongji University
2024
Zhongshan Hospital
2024
Fudan University
2002-2024
Sun Yat-sen University
2016-2024
Large bone defects resulting from fractures and disease are a major clinical challenge, being often unable to heal spontaneously by the body's repair mechanisms. Lines of evidence have shown that hypoxia-induced overproduction ROS in defect region has impact on delaying regeneration. However, replenishing excess oxygen short time cause high tension affect activity osteoblast precursor cells. Therefore, reasonably restoring hypoxic condition microenvironment is essential for facilitating...
The development of near-infrared (NIR) J-aggregates has received increasing attention due to their broad applications. Here, we report the nitrosation an amine-containing aza-BODIPY precursor (BDP-NH2 ), affording first nitric oxide (NO)-releasing NIR J-aggregate (BDP-NO). introduction N-nitrosamine moieties efficiently inhibits aromatic interactions BDP-NH2 , which instead promotes formation within micellar nanoparticles with a remarkable bathochromic shift ≈109 nm window (820 nm)....
Despite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy remains limited by the insufficient response in "cold" tumor. Nanozyme-based antitumor catalysis is associated with precise activation tumor microenvironment (TME). In this study, a cascade-augmented nanoimmunomodulator (CMZM) multienzyme-like activities, which includes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione oxidase (GSHOx), that dissociates under an acidic abundant...
Lung cancer is often asymptomatic or causes only nonspecific symptoms in its early stages. Early detection represents one of the most promising approaches to reduce growing lung burden. Human saliva an attractive diagnostic fluid because collection less invasive than that tissue blood. Profiling proteins over course disease progression could reveal potential biomarkers indicative oral systematic diseases, which may be used extensively future medical diagnostics. There were 72 subjects...
Abstract A new synergistic treatment that combines photothermal therapy (PTT) and inflammation‐mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the tumor ablation accompanied by an inflammatory effect upregulation of factors at site, which may accelerate regeneration. Moreover, PTT‐induced inflammation can also recruit neutrophils (NEs) to site. To convert disadvantages into strengths, NEs are investigated as for IMAT further inhibit...
This paper targets the day-time charging scenario for plug-in electric vehicles at parking-lots near commercial places, where most have extended parking time. Compared with night-time charge scenarios residential buildings, building parking-lot during feature significant stochastic vehicle arrival and departure, as well highly dynamic electricity price. A two-stage approximate programming framework is proposed to determine optimal strategy, utilizing predicted short-term future information...
Indocyanine green (ICG) is capable of inducing a photothermal effect and the production cytotoxic reactive oxygen species for cancer therapy. However, major challenge in applying ICG molecules antitumor therapy associated with their instability aqueous conditions rapid clearance from blood circulation, which causes insufficient bioavailability at tumor site. Herein, we conjugated Prussian blue nanoparticles enclosing Fe3O4 nanocore, was facilitated by cationic polyethyleneimine via...
Abstract Encapsulation of active biomolecules and/or nanoparticles in metal–organic frameworks (MOFs) remains a great challenge biomedical applications. In this work, through stepwise situ growth method, black phosphorus quantum dot (BQ) and catalase were precisely encapsulated into the inner outer layers MOFs, respectively. The integrated MOF system as tandem catalyst could convert H 2 O MOF‐stabilized layer, then was directly injected MOF‐sensitized BQ inner, leading to high yield singlet...
Abstract To realize sensing and labeling biomarkers is quite challenging in terms of designing multimodal imaging probes. In this study, we developed a novel β ‐galactosidase ( ‐gal) activated bimodal probe that combines near‐infrared (NIR) fluorescence magnetic resonance (MRI) to enable real‐time visualization activity living organisms. Upon ‐gal activation, Gal‐Cy‐Gd‐1 exhibits remarkable 42‐fold increase NIR intensity at 717 nm, allowing covalent adjacent target enzymes or proteins...
The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, low response limits immunotherapy efficiency. Here, we report a ROS-responsive Fe
Abstract The limited regulation strategies of the regeneration microenvironment significantly hinder bone defect repair effectiveness. One potential solution is using biomaterials capable releasing bioactive ions and biomolecules. However, most existing lack real‐time control features, failing to meet high requirements. Herein, a new Strontium (Sr) epigallocatechin‐3‐gallate (EGCG) based metal–phenolic network with polydopamine (PMPNs) modification prepared. This material reinforces...
Three hyperbranched fluoropolymers were synthesized and their micelles constructed as potential 19F MRI agents. A star-like core was first via atom transfer radical self-condensing vinyl (co)polymerization (ATR-SCVCP) of 4-chloromethyl styrene (CMS), lauryl acrylate (LA), 1,1,1-tris(4′-(2′′-bromoisobutyryloxy)phenyl)ethane (TBBPE). The polymerization gave a small with Mn 5.5 kDa PDI 1.6, which served macroinitiator. Trifluoroethyl methacrylate (TFEMA) tert-butyl (tBA) in different ratios...
Chiral transfer: The fluorinated sulfoximine (see scheme; Ts=p-toluenesulfonyl) was synthesized and used as the first chiral fluoromethylenation reagent for synthesis of cyclopropanes that contain tertiary stereogenic carbon centers in good yields, diastereoselectivity, excellent enantioselectivity.
Due to the limitation of inorganic nanomaterials in present clinical applications induced by their inherent nonbiodegradability and latent long-term side effects, we successfully prepared double switch degradable clearable trinickel monophosphide porous hollow nanospheres (NiP PHNPs) modified with bovine serum albumin (BSA). Attributed acidic oxidative degradation capacities, NiP PHNPs can be effectively excreted from mice without toxicity. Moreover, because paramagnetic high molar...
In spite of widespread applications nano-photosensitizers, poor tumor penetration and severe hypoxia in the microenvironment (TME) always result an undesirable therapeutic outcome photodynamic therapy (PDT). Herein, a biocompatible agarose-based hydrogel incorporated with sodium humate (SH), manganese oxide (MnO2) chlorin e6 (Ce6) was synthesized as agarose@SH/MnO2/Ce6 through "co-trapped" strategy during sol-gel process employed for combined photothermal (PTT) enhanced PDT. NIR-induced...
Nitroreductase (NTR) is an important biomarker widely used to evaluate the degree of tumor hypoxia. Although a few optical methods have been reported for detecting nitroreductase at low concentration ranges, effective strategy monitoring in vivo without limits imaging depth still lacking. Herein, novel dual-mode NIR fluorescence and 19 F MRI agent, FCy7-NO2 , proposed We show that serves as not only rapid enhanced probe bioimaging tumors, but also MR chemical shift-sensitive contrast agent...
Transarterial radioembolization (TARE) is a local radionuclide therapy and successfully used in hepatocellular carcinoma (HCC) treatment. Radioactive microspheres have been widely studied for TARE. Preparation of ideal radioactive significant clinical research patient In this study, we designed novel multifunctional microsphere, i.e., polydopamine (PDA)-coated 177Lu-radiolabeled silica (MS) denoted as 177Lu-MS@PDA, which can be TARE photothermal (PTT). The radiostability 177Lu-MS@PDA was...
We aimed to demonstrate the feasibility of generating high-resolution human brain magnetic resonance imaging (MRI) at 5 Tesla (T) using a quadrature birdcage transmit/48-channel receiver coil assembly.A assembly was designed for 5T. The radio frequency (RF) validated by electromagnetic (EM) simulations and phantom experimental studies. simulated B1+ field inside head model generated coils driven in circularly polarized (CP) mode 3T, 5T 7T compared. Signal-to-noise ratio (SNR) maps, inverse...
Abstract Mechanically induced disorder–order transitions have been studied in fluid surfactant solutions or polymer thermotropic liquid crystals. However, isothermally ordered phases do not persist after cessation of shear, which limits their technological applicability. Moreover, no such stimuli‐responsive materials involving biomacromolecules reported although biopolymer liquids are gaining a lot attention. A biological system is introduced anionic polypeptides complexed with cationic...