A5029529654- Lignin and Wood Chemistry
- Plant-based Medicinal Research
- Potato Plant Research
- Pharmacological Effects of Natural Compounds
- Metallurgy and Material Science
- Zebrafish Biomedical Research Applications
- Enzyme-mediated dye degradation
- Oxidative Organic Chemistry Reactions
- Advanced Cellulose Research Studies
- Sulfur Compounds in Biology
- Polymer Science and PVC
- Fermentation and Sensory Analysis
- Sesame and Sesamin Research
- Bioactive Natural Diterpenoids Research
- Material Properties and Processing
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
- Bioactive natural compounds
- Berberine and alkaloids research
- Phytochemicals and Antioxidant Activities
- Ferroptosis and cancer prognosis
- Plant pathogens and resistance mechanisms
- Neuroscience and Neuropharmacology Research
- Postharvest Quality and Shelf Life Management
- Traditional Chinese Medicine Analysis
Chengdu University of Traditional Chinese Medicine
2018-2025
Northwestern Polytechnical University
2023
Fuyang City People's Hospital
2021
University of Miami
2020
Huazhong University of Science and Technology
2015-2018
Ministry of Ecology and Environment
2015
China Agricultural University
2012-2014
Shanghai Jiao Tong University
2014
École Polytechnique Fédérale de Lausanne
2013
ETH Zurich
2013
Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Melatonin (MT) shown to be potentially effective preventing oxidative stress related neurodegenerative disorders. In this study, whether MT exerted protective effect against ACR-induced damage was investigated. Results cells showed that reactive oxygen species (ROS) malondialdehyde (MDA) significantly increased after ACR treatment for 24 h. preconditioning or cotreatment with reduced ROS MDA products, whereas...
Bone metastasis is a frequent complication of breast cancer that often accelerated by TGF-β signaling; however, little known about how the pathway regulated during bone metastasis. Here we report deleted in liver 1 (DLC1) an important regulator responses and osteolytic cells. In murine models, cells lacking DLC1 expression exhibited enhanced capabilities Knockdown promoted metastasis, leading to manifested osteolysis death mice, while overexpression suppressed Activation Rho-ROCK signaling...
Grape seeds are rich in nutrients possessing high nutritional and medicinal value. seed extract (GSE) mainly contains 15 phenolic compounds, such as (+)-catechin, (−)-epicatechin, proanthocyanidin, gallate, flavonols others. Several studies on GSE its components indicated that it has pharmacological attributes, antioxidation, anti-inflammation, anticancer, neuroprotection, lowering lipid, bacteriostatic, reduced blood pressure. This article reviewed the research progress bioactivity of...
In this study, a high sensitive and selective hydrogen peroxide (H2O2) sensor was successfully constructed with Pt-Au bimetallic nanoparticles (Pt-Au NPs)/reduced graphene sheets (rGSs) hybrid films. Various molar ratios of Au to Pt different electrodeposition conditions were evaluated control the morphology electrocatalytic activity nanoparticles. Upon optimal conditions, wide linear ranges from 1 µM 1.78 mM 16.8 obtained, detection limit as low 0.31 µM. Besides, due synergetic effects NPs...
Coronary heart disease (CHD), the leading cause of death globally, might be developed or exacerbated by air pollution, resulting high burden to patients. To date, limited studies have estimated relations between short-term exposure pollution and CHD in China, with inconsistent results. Hence, we aimed estimate impact ambient PM pollutants on hospitalizations specific CHD.PM10 PM2.5 were measured at 82 monitoring stations 9 cities Sichuan Province, China during 2017-2018. Based...
Trimethyltin chloride (TMT) is a classic neurotoxicant that can cause severe neurodegenerative diseases. Some signaling pathways involving cell death play pivotal roles in the central nervous system. In this study, role of Sonic Hedgehog (Shh) and PI3K/Akt TMT-induced apoptosis protective effect Lycium barbarum polysaccharides (LBP) on mouse neuro-2a (N2a) cells were investigated. Results showed TMT treatment significantly enhanced apoptosis, upregulated proapoptotic Bax, downregulated...
Fuzi, a Chinese herb widely used in clinical settings, exhibits varying levels of toxicity depending on its geographical origin. Diester-type alkaloids are the primary contributors to Fuzi. This study aims investigate regional differences and underlying mechanisms Fuzi-induced neurotoxicity across China. Matrix-assisted laser desorption/Ionization mass spectrometry imaging (MALDI-MSI) method was employed map spatial distribution six key diester-type from Fuzi samples originating five major...
Acrylamide (ACR), a common environmental and food contaminant, can cause neurotoxicity increase the risk of neurodegenerative diseases. While induced by high-dose ACR exposure in occupational workers is evident, potential adverse effects low-dose daily remain subject debate. In this present study, we aim to explore whether induces based on interactions between microglia neurons. Results demonstrated that did not significantly impair mitochondrial homeostasis SH-SY5Y cells, but microglial...
Green-ripe (Gr) tomato carries a dominant mutation and yields nonripening fruit phenotype. The results from 334 bp deletion in gene of unknown function at the Gr locus. putative influence gene-deletion on biochemical changes underlying phenotype remains largely unknown. Respiration was found to be reduced mature green breaker stage ripening, while softening dramatically prolonged. We studied proteome mutant using high-throughput iTRAQ high-resolution mass spectrometry identified 43 proteins...
Abstract Acrylamide (ACR) is a potent neurotoxin that can be produced during high‐temperature food processing, but the underlying toxicological mechanism remains unclear. In this study, detrimental effects of ACR on striatal dopaminergic neurons and roles mitogen‐activated protein kinases (MAPKs) nuclear factor κB (NF‐κB) in ACR‐induced neuronal apoptosis were investigated. Acute exposure caused loss as revealed by decreased tyrosine hydroxylase (TH)‐positive cells TH level increased...