A novel type of cellular-uptake-shielding multifunctional envelope-type mesoporous silica nanoparticle (MEMSN) was designed for tumor-triggered targeting drug delivery to cancerous cells. β-Cyclodextrin (β-CD) anchored on the surface nanoparticles via disulfide linking glutathione-induced intracellular release. Then a peptide sequence containing Arg-Gly-Asp (RGD) motif and matrix metalloproteinase (MMP) substrate Pro-Leu-Gly-Val-Arg (PLGVR) introduced onto host–guest interaction. To protect...

In this study, we developed a general method to decorate plasmonic gold nanorods (GNRs) with CD44-targeting functional polymer, containing hyaluronic acid (HA)-targeting moiety and small molecule Glut1 inhibitor of diclofenac (DC), obtain GNR/HA-DC. This nanosystem exhibited the superiority selectively sensitizing tumor cells for photothermal therapy (PTT) by inhibiting anaerobic glycolysis. Upon specifically targeting CD44, sequentially time-dependent DC release could be achieved trigger...

Functional mesoporous silica particles have attracted growing research interest for controlled drug delivery in targeted cancer therapy. For the purpose of efficient targeting tumor cells and reducing adverse effect antitumor doxorubicin (DOX), biocompatible enzyme-responsive nanoparticles (MSNs) with specificity were desired. To construct these functional MSNs, classic rotaxane structure formed between alkoxysilane tether α-cyclodextrin (α-CD) was employed to anchor onto orifices MSNs as...

Zeolitic Zn2+-imidazolate cross-linked framework nanoparticles, ZIF-8 NMOFs, are used as "smart" glucose-responsive carriers for the controlled release of drugs. The NMOFs loaded with respective drug and glucose oxidase (GOx), GOx-mediated aerobic oxidation yields gluconic acid H2O2. acidification NMOFs' microenvironment leads to degradation nanoparticles In one sense-and-treat system, GOx insulin in NMOFs. presence glucose, unlocked, resulting insulin. is by concentration glucose. second...

To integrate treatments of photothermal therapy, photodynamic therapy (PDT), and chemotherapy, this study reports on a multifunctional nanocomposite based mesoporous silica‐coated gold nanorod for high‐performance oncotherapy. Gold core is used as the hyperthermal agent silica shell reservoir photosensitizer (Al(III) phthalocyanine chloride tetrasulfonic acid, AlPcS 4 ). The modified with β‐cyclodextrin (β‐CD) gatekeeper via redox‐cleavable Pt(IV) complex controlled drug release....

A multifunctional enveloped nanodevice based on mesoporous silica nanoparticle (MSN) was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor cells. Mesoporous MCM-41 nanoparticles were used as the core loading antineoplastic topotecan (TPT). The surface decorated with mitochondria-targeted agent (Tpep) containing triphenylphosphonium (TPP) antibiotic (KLAKLAK)2 via disulfide linkage, followed by coating a charge reversal polyanion poly(ethylene...

Novel PEG–polypeptide hybrid drug carriers, poly(ethylene glycol)-b-poly(L-cysteine)-b-poly(L-phenylalanine) (PEG-PCys-PPhe) triblock copolymers, were prepared via the ring-opening polymerization of amino acid N-carboxyanhydrides. The copolymers can self-assemble to form core–shell–corona micelles in aqueous solutions. shell has ability self-cross-link (SCL) by oxidation thiol groups PCys segments. morphology and stability SCL characterized TEM, DLS SEM. results showed could hold physical...

Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The able enhance cell uptake via the receptor-mediated endocytosis and respond stimulus of excessive secreted protease MMP-2 release anticancer drug induce apoptosis cells in a targeted manner.

Poor tumor selectivity and short life span of reactive oxygen species (ROS) are two major challenges in photodynamic therapy (PDT). In this study, a self‐transformable pH‐driven membrane anchoring photosensitizer (pHMAPS) is used to realize tumor‐specific accumulation situ PDT on cell maximize the therapeutic potency. It found that pHMAPS was able form α‐helix structure under acidic condition (pH 6.5 or 5.5), while remain random coil at normal pH 7.4. This secondary switch enables successful...

The excessive lactate in the tumor microenvironment always leads to poor therapeutic outcomes of chemotherapy. In this study, a self-driven bioreactor (defined as SO@MDH, where SO is Shewanella oneidensis MR-1 and MDH MIL-101 metal–organic framework nanoparticles/doxorubicin/hyaluronic acid) rationally constructed via integration doxorubicin (DOX)-loaded (MOF) nanoparticles with sensitize Owing intrinsic tropism electron-driven respiration SO, biohybrid SO@MDH could actively target colonize...

Macrophage-mediated cellular phagocytosis (MMCP) plays a critical role in conducting antitumor immunotherapy but is usually impaired by the intrinsic evading ability of tumor cells and immunosuppressive microenvironment (TME). Herein, MMCP-boosting hydrogel (TCCaGM) was elaborately engineered encapsulating granulocyte-macrophage colony-stimulating factor (GM-CSF) therapeutic nanoplatform (TCCaN) that preloaded with tunicamycin (Tuni) catalase (CAT) assistance CaCO3 nanoparticles (NPs)....

Supramolecular microcapsules (SMCs) with the drug-loaded wall layers for pH-controlled drug delivery were designed and prepared. By using layer-by-layer (LbL) technique, SMCs constructed based on self-assembly between polyaldenhyde dextran-graft-adamantane (PAD-g-AD) carboxymethyl dextran-graft-β-CD (CMD-g-β-CD) CaCO3 particles via host-guest interaction. Simultaneously, adamantine-modified doxorubicin (AD-Dox) was also loaded LbL The in vitro release study carried out at different pHs....

Mitochondria are vital organelles to eukaryotic cells. Damage mitochondria will cause irreversible cell death or apoptosis. In this report, we aim at programmed cancer via specific mitochondrial damage. Herein, a functionalized pro-apoptotic peptide demonstrates dual-targeting capability using folic acid (FA) (targeting agent I) and triphenylphosphonium (TPP) cation II). FA is cancer-targeting agent, which can increase the cellular uptake of receptor-mediated endocytosis. And TPP targeting...

Mesoporous silica nanoparticles (MSNs) have proved to be an effective carrier for controlled drug release and can functionalized easily use as stimuli-responsive vehicles. Here, a novel intelligent drug-delivery system (DDS), camptothecin (CPT)-loaded doxorubicin (DOX)-conjugated MSN (CPT@MSN-hyd-DOX), is reported via facile one-pot preparation in synergistic chemotherapy of glioblastoma. DOX was conjugated MSNs acid-labile hydrazone bonds, CPT loaded the pores MSNs. At pH 6.5 (analogous...

To develop a smart nanovalve on mesoporous silica nanoparticles (MSNs) for biomedical applications, new type of peptide-functionalized MSN with plug-gate (PGN) was designed targeted drug release in cancer cells. The outer shell functionalized K8 peptide (octa-lysine sequence) by click chemistry, followed reacting citraconic anhydride via α,β-unsaturated bond to prepare negatively charged MSN–K8(Cit). Subsequently, cationic K8(RGD)2 containing two Arg–Gly–Asp (RGD) sequences targeting...

Nanomaterials that integrate diagnostic and therapeutic functions within a single nanoplatform promise great advances in revolutionizing cancer therapy. A smart multifunctional theranostic drug‐delivery system (DDS) based on gold nanorods (abbreviated as GNR/TSDOX) is designed for cancer‐targeted imaging imaging‐guided In this intelligent DDS, the active targeting ligand biotin introduced to track sites vivo. With aid of photothermal/photoacoustic imaging, GNR/TSDOX can ablate specifically...

Graphene oxide (GO)‐based theranostic nanohybrid is designed for tumor induced imaging and potential combinational therapy. The anti‐tumor drug, Doxorubicin (DOX) chemically conjugated to the poly(ethylenimine)‐co‐poly(ethylene glycol) (PEI‐PEG) grafted GO via a MMP2‐cleavable PLGLAG peptide linkage. therapeutic efficacy of DOX locked its intrinsic fluorescence quenched by under normal physiological condition. Once stimulated MMP2 enzyme over‐expressed in tissues, resulting cleavage permits...

Multidrug resistance (MDR) is one of the main causes failure in cancer chemotherapy. To address this challenge, work develops a tumor-triggered nanomedicine (HA-MSDOX-KLA; comprised tumor active targeting segment (hyaluronic acid, HA) and two programmed therapeutic agents, MMP-substrate peptide (CPLGLAGG) conjugated doxorubicin (designated as MSDOX) proapoptotic (KLAKLAK)2 KLA)) with switchable morphology transformation that significantly enhances tumor-specific accumulation retention for...

Poly(N-isopropylacrylamide) (PNIPAAm)-based thermally responsive micelles are of great importance as smart materials for a number applications such drug delivery and biosensing, owing to their tunable lower critical solution temperature (LCST). Their design synthesis in the nanoscale size range have been widely studied, research interest structural physic-chemical properties is continually growing. In this Viewpoint, representative on construction PNIPAAm-based well highlighted discussed,...