A5036666980- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Hydrogels: synthesis, properties, applications
- Surgical Sutures and Adhesives
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Graphene and Nanomaterials Applications
- Connective tissue disorders research
- Polymer Surface Interaction Studies
- Neuroscience and Neural Engineering
- Additive Manufacturing and 3D Printing Technologies
- Corneal Surgery and Treatments
- Silk-based biomaterials and applications
- Hemostasis and retained surgical items
- Ocular Surface and Contact Lens
- Innovative Microfluidic and Catalytic Techniques Innovation
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Conducting polymers and applications
- Advanced Drug Delivery Systems
- Cellular Mechanics and Interactions
- Collagen: Extraction and Characterization
- Nerve injury and regeneration
Massachusetts Institute of Technology
2014-2025
University of California, Los Angeles
2018-2025
Harvard–MIT Division of Health Sciences and Technology
2013-2025
California NanoSystems Institute
2019-2025
Brigham and Women's Hospital
2013-2024
Harvard University
2013-2024
Northeastern University
2015-2024
University of Nebraska–Lincoln
2021
Samueli Institute
2018-2021
Innovation Research Center
2014-2019
Functional carbon-based nanomaterials (CBNs) have become important due to their unique combinations of chemical and physical properties (i.e., thermal electrical conductivity, high mechanical strength, optical properties), extensive research efforts are being made utilize these materials for various industrial applications, such as high-strength electronics. These advantageous CBNs also actively investigated in several areas biomedical engineering. This Perspective highlights different types...
Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural used support epidermal regeneration mainly collagen‐ or gelatin‐based, which mimic the dermal extracellular matrix but often suffer from insufficient and uncontrollable mechanical degradation properties. In this study, a photocrosslinkable gelatin (i.e., methacrylamide (GelMA)) with tunable mechanical, degradation, biological properties is epidermis for skin tissue engineering applications. The results reveal...
The inadequacy of animal models in correctly predicting drug and biothreat agent toxicity humans has resulted a pressing need for vitro that can recreate the vivo scenario. One most important organs assessment is liver. Here, we report development liver-on-a-chip platform long-term culture three-dimensional (3D) human HepG2/C3A spheroids assessment. bioreactor design allowed situ monitoring environment by enabling direct access to hepatic construct during experiment without compromising...
Fabricating 3D large‐scale bone tissue constructs with functional vasculature has been a particular challenge in engineering tissues suitable for repairing large defects. To address this challenge, an extrusion‐based direct‐writing bioprinting strategy is utilized to fabricate microstructured bone‐like containing perfusable vascular lumen. The bioprinted are used as biomimetic vitro matrices co‐culture human umbilical vein endothelial cells and marrow derived mesenchymal stem naturally...
Biomimetic hybrid hydrogels have generated broad interest in tissue engineering and regenerative medicine. Hyaluronic acid (HA) gelatin (hydrolyzed collagen) are naturally derived polymers biodegradable under physiological conditions. Moreover, collagen HA major components of the extracellular matrix (ECM) most tissues (e.g., cardiovascular, cartilage, neural). When used as a material, HA-gelatin may enable mimicking ECM native tissues. Although promising biomimetic substrates, their...
A highly elastic and adhesive photocrosslinkable surgical sealant using a modified human protein controls liquid leakages without the need for suturing.
Corneal injuries are common causes of visual impairment worldwide. Accordingly, there is an unmet need for transparent biomaterials that have high adhesion, cohesion, and regenerative properties. Herein, we engineer a highly biocompatible bioadhesive corneal reconstruction using visible light cross-linkable, naturally derived polymer, GelCORE (gel regeneration). The physical properties could be finely tuned by changing prepolymer concentration photocrosslinking time. revealed higher tissue...
Abstract Chronic wounds are characterized by impaired healing and uncontrolled inflammation, which compromise the protective role of immune system may lead to bacterial infection. Upregulation miR‐223 microRNAs (miRNAs) shows driving polarization macrophages toward anti‐inflammatory (M2) phenotype, could aid in acceleration wound healing. However, local‐targeted delivery is still challenging, due their low stability. Here, adhesive hydrogels containing 5p mimic (miR‐223*) loaded hyaluronic...
A highly elastic hybrid hydrogel of methacryloyl-substituted recombinant human tropoelastin (MeTro) and graphene oxide (GO) nanoparticles are developed. The synergistic effect these two materials significantly enhances both ultimate strain (250%), reversible rotation (9700°), the fracture energy (38.8 ± 0.8 J m−2) in network. Furthermore, improved electrical signal propagation subsequent contraction muscles connected by hydrogels observed ex vivo tests.
Engineering visible light crosslinked GelMA hydrogels with tunable physical properties.