A5003833924- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Hematopoietic Stem Cell Transplantation
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- Laser Applications in Dentistry and Medicine
- Wound Healing and Treatments
- Neonatal Respiratory Health Research
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Hydrogen's biological and therapeutic effects
- Renal cell carcinoma treatment
- Immune cells in cancer
- Platelet Disorders and Treatments
- Ion Transport and Channel Regulation
- Cardiac Fibrosis and Remodeling
- Chemical Reactions and Isotopes
- Acute Kidney Injury Research
- Telomeres, Telomerase, and Senescence
Institute of Hematology & Blood Diseases Hospital
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Cell Technology (China)
2015-2024
Sinovac Biotech
2021-2024
Tianjin Medical University
2024
Tianjin University
2024
Hangzhou Institute of Applied Acoustics
2023
Chaohu University
2021-2022
Guangxi Normal University
2022
Tianjin University of Commerce
2021
Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for cell-free treatment of various diseases. However, maintaining the retention and stability over time in vivo after transplantation is a major challenge clinical application MSC-derived exosomes. Here, we investigated if human placenta-derived incorporated with chitosan hydrogel could boost further enhance their therapeutic effects. Our results demonstrated that notably increased proteins microRNAs...
Wound healing is regulated by a complex series of events and overlapping phases. A delicate balance cytokines mediators in tissue repair required for optimal therapy clinical applications. Molecular imaging technologies, with their versatility monitoring cellular molecular living organisms, offer tangible options to better guide regulating the at injured sites. Methods: murine cutaneous wound model was developed investigate if incorporation prostaglandin E2 (PGE2) into chitosan (CS) hydrogel...
Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from different tissues share many similarities but also show some differences term biological properties. We aim to search for significant among various sources explore their implications physiopathology clinical translation. compared phenotype properties isolated human placental chorionic villi (CV), umbilical cord (UC), adult bone marrow...
Background: The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role adipogenic differentiation human bone marrow derived MSCs (BM-MSCs). Methods: inhibited by γ-secretase inhibitor N-[N-(3,5-difluor- ophenacetyl-L-alanyl)]-S-phenylglycine t-butylester (DAPT). markers involving MSCs, relative PTEN-PI3K/Akt/mTOR and autophagy activation were then analyzed. Furthermore, chloroquine (CQ)...
Background: Mesenchymal stem cell (MSC)-based therapies hold great promise for the treatment of inflammatory bowel disease (IBD). In order to optimize and maximize therapeutic benefits MSCs, we investigated whether cotransplantation a chitosan (CS)-based injectable hydrogel with immobilized IGF-1 C domain peptide (CS-IGF-1C) human placenta-derived MSCs (hP-MSCs) could ameliorate colitis in mice. Methods: IGF-1C was generated by immobilizing CS hydrogel. Colitis induced 2,4,6-trinitrobenzene...
Multipotent mesenchymal stromal cell (MSC) therapy has been widely recognized as a feasible strategy for regenerating injured myocardial tissue. However, little is known about the efficacy of intravenous injection allogeneic umbilical cord (UC) MSCs in preclinical models porcine infarction.Different dosages UC-MSCs or vehicle [phosphate-buffered saline (PBS)] were delivered intravenously into an acute infarction (AMI) model twice after coronary ligation. Echocardiography was performed to...
Aims: Radiotherapy is an effective treatment for thoracic malignancies, but it can cause pulmonary injury and may lead to respiratory failure in a subset of patients. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are now recognized as new candidate cell-free lung diseases. Here, we investigated whether MSC-derived EVs (MSC-EVs) could ameliorate radiation-induced injury. Results: We exposed mice radiation with total dose 15 Gy assessed the protective effects MSC-EVs...
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to therapeutic potential for ischemic diseases and are considered an alternative therapy. However, the low retention poor stability of EVs post-transplantation in vivo remain obstacle prior clinical application EVs.This study was designed investigate whether collagen matrix could increase further improve effects murine acute kidney injury (AKI) model. were isolated from human placental MSCs (hP-MSC-EVs)...
Abstract Background The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP), which ultimately skin aging. Recently, mesenchymal stem cell (MSC)-derived vesicles (EVs) have been recognized as a promising cell-free therapy for degenerative diseases, opens new avenue aging treatment. Methods In this study, we utilized chitosan (CS) hydrogel...
Abstract Endothelial cell injury plays a critical part in ischemic acute kidney (AKI) and participates the progression of AKI. Targeting renal endothelial therapy may ameliorate vascular further improve prognosis Here, P‐selectin as biomarker AKI cells is identified binding peptide (PBP)‐engineered extracellular vesicles (PBP‐EVs) with imaging therapeutic functions are developed. The results show that PBP‐EVs exhibit selective targeting tendency to injured kidneys, while providing...
Patients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising alternative, capitalizing on their low immunogenicity potent immunomodulatory effects for treating diverse autoimmune disorders. This prospective phase I trial enrolled eighteen eligible patients explore the safety efficacy of UC-MSCs in ITP. The research...
Cell-based therapy represents a promising strategy in the treatment of neurological disorders. Human umbilical cord tissue has recently been recognized as an ideal source mesenchymal stromal cells due to accessibility, vast abundance and safety. Here, intracerebral hemorrhage (ICH) rat model was established by injection bacterial collagenase VII CM-DiI labeled human derived (UC-MSC) were intracerebrally transplanted into brain 24h after ICH. The results demonstrated that UC-MSC significantly...
Neovasculogenesis induced by stem cell therapy is an innovative approach to improve critical limb ischemia (CLI) in diabetes. Mesenchymal cells (MSCs) are ideal candidates due their angiogenic and immunomodulatory features. The aim of this study determine the therapeutic effects human placenta-derived MSCs (P-MSCs) on diabetic CLI, with or without exogenous insulin administration, underlying mechanism any effect. A series vitro experiments were performed assess stemness vasculogenic activity...
With the immunoregulation potential, mesenchymal stem cells (MSCs) have been used for tissue regeneration by relieving inflammation in injured tissues. When this repair process is interfered immune disorders or pathological angiogenesis, delays corneal epithelial wound healing can lead to a persistent defect. Stem cell-derived extracellular vesicles (EVs), which carry abundant bioactive molecules from cells, provided an alternative therapy. In study, we aimed investigate if EVs human...
Mesenchymal stem cell (MSC)–derived extracellular vesicles (EVs) have been shown to stimulate regeneration in the treatment of kidney injury. Renal is also thought be stimulated by activation Sox9+ cells. However, whether and how mechanisms underlying EV cell–dependent intersect unclear. We reasoned that a high-resolution imaging platform living animals could help untangle this system. To test idea, we first applied EVs derived from human placenta–derived MSCs (hP-MSCs) Sox9-CreERT2; R26mTmG...
Longitudinal studies have indicated VCAM-1+ mesenchymal stem/stromal cells (MSCs) as promising resources in regenerative medicine, yet the abundance gene expression is far from adequate advantaged and "discarded" hUC-MSCs. Thus, high-efficient preparation systematic dissection of signatures biofunctions subpopulation prerequisite for large-scale clinical applications.We primarily took advantage a cytokine-based programming strategy hUC-MSC generation (III-MSCs). Thereafter, we conducted...
Abstract Background Mesenchymal stem cells (MSCs) have demonstrated remarkable therapeutic promise for acute lung injury (ALI) and its severe form, respiratory distress syndrome (ARDS). MSC secretomes contain various immunoregulatory mediators that modulate both innate adaptive immune responses. Priming MSCs has been widely considered to boost their efficacy a variety of diseases. Prostaglandin E2 (PGE2) plays vital role in physiological processes mediate the regeneration injured organs....
Therapies based on stem cells have shown very attractive potential in many clinical studies. However, the data about safety of application remains insufficient. The present study was designed to evaluate overall toxicology human umbilical cord mesenchymal (hUC-MSCs) cynomolgus monkeys with repeated administrations. hUC-MSCs were administered by intravenous injection once every 2 weeks for 6 weeks. dose levels employed this 2×106, 1×107 cells/kg body weight. Toxicity evaluated observations...
Abstract Background Intravenous administration of mesenchymal stromal cells (MSCs) has an acknowledged competence cardiac repair, despite a lack systematic description the underlying biological mechanisms. The lung, but not heart, is main trapped site for intravenously transplanted MSCs, which leaves spatial gap between MSCs and injured myocardium. How lung-trapped after intravenous transplantation rejuvenate myocardium remains unknown. Methods were isolated from human placenta tissue,...