A5100748829- Mesenchymal stem cell research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Immune cells in cancer
- Extracellular vesicles in disease
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Inflammasome and immune disorders
- Bone and Joint Diseases
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Hematological disorders and diagnostics
- Antifungal resistance and susceptibility
- Angiogenesis and VEGF in Cancer
- Inflammatory mediators and NSAID effects
- Acute Myeloid Leukemia Research
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Retinoids in leukemia and cellular processes
Institute of Hematology & Blood Diseases Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Bengbu Medical College
2024
National Clinical Research
2023
Peking Union Medical College Hospital
2008-2022
Nankai University
2018
Edwards Lifesciences (United States)
2015-2016
University of California, Irvine
2015-2016
The Military General Hospital of Beijing PLA
2016
Shenyang Aerospace University
2013
Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for cell-free treatment of various diseases. However, maintaining the retention and stability over time in vivo after transplantation is a major challenge clinical application MSC-derived exosomes. Here, we investigated if human placenta-derived incorporated with chitosan hydrogel could boost further enhance their therapeutic effects. Our results demonstrated that notably increased proteins microRNAs...
Abstract Both lytic and apoptotic cell death remove senescent damaged cells in living organisms. However, they elicit contrasting pro- anti-inflammatory responses, respectively. The precise cellular mechanism that governs the choice between these two modes of remains incompletely understood. Here we identify Gasdermin E (GSDME) as a master switch for neutrophil pyroptotic death. tightly regulated GSDME cleavage activation aging neutrophils are mediated by proteinase-3 caspase-3, leading to...
Abstract Introduction Mesenchymal stem cells (MSCs) represent a heterogeneous cell population that is promising for regenerative medicine. The present study was designed to assess whether VCAM-1 can be used as marker of MSC subpopulation with superior angiogenic potential. Methods MSCs were isolated from placenta chorionic villi (CV). +/− CV-MSCs separated by Flow Cytometry and subjected comparative analysis their properties including genes expression, vasculo-angiogenic abilities on...
Candida albicans is the most common cause of fungal sepsis. Inhibition inflammasome activity confers resistance to polymicrobial and LPS-induced sepsis; however, signaling appears protect against C. infection, so inhibitors are not clinically useful for candidiasis. Here we show disruption GSDMD, a known target key pyroptotic cell death mediator, paradoxically alleviates candidiasis, improving outcomes survival Candida-infected mice. Mechanistically, hijacked canonical inflammasome-GSDMD...
The Sonic hedgehog (SHH) protein produced in the zone of polarising activity (ZPA) is a major determinant identity and numbers digits early limb development. Preaxial polydactyly types II (PPD2) III (PPD3) have been mapped to critical region at 7q36, subsequently shown be caused by point mutations ZPA regulatory sequence (ZRS), long range cis-regulator for SHH gene. Triphalangeal thumb-polysyndactyly syndrome (TPTPS) syndactyly type IV (SD4) were also 7q36 but pathogenic ZRS not yet...
Aplastic anemia (AA) is generally considered as an immune-mediated bone marrow failure syndrome with defective hematopoietic stem cells (HSCs) and microenvironment. Previous studies have demonstrated the HSCs aberrant T cellular-immunity in AA using a microarray approach. However, little known about overall specialty of mesenchymal (BM-MSCs). In present study, we comprehensively compared biological features gene expression profile BM-MSCs between patients healthy volunteers. comparison...
Although emerging evidence links mesenchymal stem cells (MSCs) with cancer metastasis, the underlying mechanisms are poorly understood. In present study, we found that human umbilical cord-derived MSCs (UC-MSCs) promoted MCF-7 cell migration in vitro and metastasis vivo. To explore mechanisms, characteristics of cocultured UC-MSCs were assessed. The expression secretion interleukin-8 (IL-8) IL-6 induced UC-MSCs. However, neutralization IL-8 or secreted by could attenuate enhanced UC-MSCs,...
Mesenchymal stem cells (MSCs) have been implicated in antitumor therapy for hematopoietic and non-hematopoietic tumors. Cell-contact soluble factors are demonstrated to play a role the growth inhibition of tumor mediated by MSCs vitro, while there is little clue about signaling pathways involved process. P38 MAPK has as suppressor cell proliferation tumorigenesis. We here investigate whether p38 MSC-induced leukemic cells.We characterized effect human umbilical cord mesenchymal (UC-MSCs) on...
Purpose of review CXCR2 is key stimulant immune cell migration and recruitment, especially neutrophils. Alleviating excessive neutrophil accumulation infiltration could prevent prolonged tissue damage in inflammatory disorders. This focuses on recent advances our understanding the role regulating use antagonists for therapeutic benefit Recent findings studies have provided new insights into how signaling regulates hematopoietic mobilization function both health disease. We also summarize...
Multiple myeloma (MM) shows inherent clinical and biological heterogeneity, leading to variable treatment responses outcomes. The complex molecular landscape of MM makes precise risk stratification through genetic testing difficult. Thus, identifying better biomarkers is essential enhance existing methods guide personalized therapy decisions. Here, we systematically analyzed the intratumor heterogeneity tumor cells from 12 newly diagnosed patients with different outcomes at single-cell...
Abstract Lin28a is a pluripotent factor that promotes somatic cell reprogramming. Unlike other factors, expression transient and accumulated in primed embryonic stem (ES) cells, but its exact function mechanism the conversion of ES cells from naïve to state remain unclear. Here, we present evidence for Dppa3, protein originally known role germ development, as downstream target naïve–primed conversion. Using rescue experiment, demonstrate Dppa3 functions predominantly during Higher level...
Aplastic anemia (AA) is a marrow failure syndrome mediated by aberrant T-cell subsets. Mesenchymal stem cells (MSCs) play an important role in maintaining immune homeostasis through modulating variety of cells. However, little known about the immunomodulation potential bone MSCs (BM-MSCs) AA. Here, we reported that BM-MSCs from AA patients were reduced suppressing proliferation and clonogenic CD4+ T production tumor necrosis factor-α (TNF-α) interferon-γ (IFN-γ), which was associated with...
Survival of neutrophils is prolonged, and their function preserved by simultaneously targeting multiple cell death pathways.