A5071209771- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Immune cells in cancer
- Antibiotic Resistance in Bacteria
- Sexual function and dysfunction studies
- Bacterial Identification and Susceptibility Testing
- Sperm and Testicular Function
- Reproductive Health and Technologies
- Circular RNAs in diseases
- Hormonal and reproductive studies
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Nutrition, Genetics, and Disease
- Reproductive tract infections research
- Reproductive Health and Contraception
- Inflammasome and immune disorders
- Sepsis Diagnosis and Treatment
- Global Public Health Policies and Epidemiology
- Leprosy Research and Treatment
- Prenatal Screening and Diagnostics
- Nutritional Studies and Diet
- Sexual Differentiation and Disorders
- Cytomegalovirus and herpesvirus research
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Institute of Hematology & Blood Diseases Hospital
2021-2025
Shanghai First Maternity and Infant Hospital
2013-2024
Southeast University
2024
National Clinical Research
2023
Huainan Normal University
2011
Harbor–UCLA Medical Center
1993
University of California, Los Angeles
1993
UCLA Medical Center
1993
Abstract Both lytic and apoptotic cell death remove senescent damaged cells in living organisms. However, they elicit contrasting pro- anti-inflammatory responses, respectively. The precise cellular mechanism that governs the choice between these two modes of remains incompletely understood. Here we identify Gasdermin E (GSDME) as a master switch for neutrophil pyroptotic death. tightly regulated GSDME cleavage activation aging neutrophils are mediated by proteinase-3 caspase-3, leading to...
Abstract The TRacing Etiology of Non-communicable Diseases (TREND) cohort is a prospective longitudinal and biobank that mainly based in Ma’anshan, Anhui Province, China. primary aim the study to decipher comprehensive molecular characterization deep phenotyping for broad spectrum chronic non-communicable diseases (NCDs), which focuses on providing mechanistic insights with diagnostic, prognostic therapeutic implications. recruitment was initiated 2023 expected complete 2025 20,000...
Abstract Background Several studies have suggested that short-course antibiotic therapy was effective in Pseudomonas aeruginosa (PA) bloodstream infections (BSI) immunocompetent patients. But similar patients with hematological malignancies were rare. Methods This cohort study included onco-hematology at 2 hematology centers China. Inverse probability of treatment weighting used to balance the confounding factors. Multivariate regression model evaluate effect on clinical outcomes. Results In...
Objective: To analyze the mental health and erectile function status of men using sperm donor during pregnancy after ICSI failure in severe oligoasthenospermia to provide reference for clinical implementation more targeted psychological intervention nursing this group. Methods: A total 410 sterile who received assisted treatment our hospital from December 2020 2022 met inclusion exclusion criteria were collected as study subjects. Among them, 68 patients with used Sixty-eight continued...
Survival of neutrophils is prolonged, and their function preserved by simultaneously targeting multiple cell death pathways.
The average lifespan of a neutrophil is less than 24 h, which limits basic research on neutrophils and the application studies. Our previous indicated that multiple pathways could mediate spontaneous death neutrophils. A cocktail was developed by simultaneously targeting these pathways, caspases-lysosomal membrane permeabilization-oxidant-necroptosis inhibition plus granulocyte colony-stimulating factor (CLON-G), prolonged to greater 5 days without significantly compromising function....
Journal Article Accepted manuscript The study design and methodology of antibiotic duration in hematological patients with pseudomonas aeruginosa bloodstream infection Get access Xiaomeng Feng, Feng State Key Laboratory Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Cell Ecosystem, Institute Hematology & Diseases Hospital, Chinese Academy Medical Sciences Peking Union College, Tianjin, ChinaTianjin Institutes Health Science, China Search other works by...
Abstract Modelling complex smoking histories, with more comprehensive and flexible methods, to show what profile of behavior is associated the risk different cancers remains poorly understood. This study aims provide insight into association between exposure history pan-cancer by modelling both intensity duration in a large-scale prospective cohort. Here, we used data including total 0.5 million cancer incidences 12 smoking-related cancers. To jointly interpret effects smoking, modelled...
Emergency myelopoiesis (EM) represents a general hematopoietic response to infection, but how infection frequency and duration are sensed is unknown. Here we describe IL1R1-mediated trained program, termed emergency (TEM), in recurring E.coli sustained C. albicans infection. IL1R1 upregulation, triggered by primary via TLR2 specific BM stem progenitor cells, formed an intrinsic transplantable short-lived hematological memory that contributed IL-1 signaling upregulation reinforced...
Objective To investigate the implementation of system older pregnant women prenatal ultrasound screening for diagnosis and clinioal significance.Methods Clinical data from March 2004 to April 2009 a total 10 630 cases receiving examination fetal malformation data,of which 712 advanced maternal age( expected date birth aged≥35 years) implement follow-up all age pregnancy outcome,the final post-natal malformations in standard,both young screened as control group comparison assess value...
Objective To label granulocytes in a state of differentiation mouse bone marrow (BM) with EdU (5-ethynyl-2′-deoxyuridine) for further understanding the changes granulocyte production at different stages during inflammation. Methods C57BL/6 mice were intraperitoneally (i.p.) injected and heat-inactivated Escherichia coli (HI E. coli). BM cells harvested time points after HI injection then stained fluorescent-conjugated antibodies (Abs). Myeloblasts, promyelocytes, myelocytes,...