A5067662514- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- Single-cell and spatial transcriptomics
- Genetic and Kidney Cyst Diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Renal and Vascular Pathologies
- Immune cells in cancer
- Immune Response and Inflammation
- Renal and related cancers
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Institute of Hematology & Blood Diseases Hospital
2019-2025
Nanfang Hospital
2022
Southern Medical University
2022
Abstract Both lytic and apoptotic cell death remove senescent damaged cells in living organisms. However, they elicit contrasting pro- anti-inflammatory responses, respectively. The precise cellular mechanism that governs the choice between these two modes of remains incompletely understood. Here we identify Gasdermin E (GSDME) as a master switch for neutrophil pyroptotic death. tightly regulated GSDME cleavage activation aging neutrophils are mediated by proteinase-3 caspase-3, leading to...
Summary The full neutrophil heterogeneity and differentiation landscape remains incompletely characterized. Here we profiled >25,000 differentiating mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional of maturation, function, fate decision in their steady state during bacterial infection. Eight populations were defined by distinct molecular signatures. three peripheral blood subsets arise from maturing bone marrow subsets. Driven both known...