A5100461284- Immune cells in cancer
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Reproductive System and Pregnancy
- Hematopoietic Stem Cell Transplantation
- Inflammasome and immune disorders
- interferon and immune responses
- Acute Myeloid Leukemia Research
- Vector-borne infectious diseases
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
- Insect symbiosis and bacterial influences
- Vasculitis and related conditions
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Fungal Biology and Applications
- Phytochemical compounds biological activities
- Cancer Immunotherapy and Biomarkers
- Reproductive tract infections research
- Chronic Kidney Disease and Diabetes
- Viral Infections and Vectors
- Tannin, Tannase and Anticancer Activities
- Folate and B Vitamins Research
- Immunotherapy and Immune Responses
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Institute of Hematology & Blood Diseases Hospital
2025
Guangzhou Medical University
2023
Key Laboratory of Guangdong Province
2023
Third Affiliated Hospital of Guangzhou Medical University
2023
Tianjin Medical University General Hospital
2019-2022
First Hospital of China Medical University
2022
China Medical University
2022
Union Hospital
2022
Jilin University
2022
Immunosuppressive tumor microenvironments (TMEs) create tremendous obstacles for an effective cancer therapy. Herein, we developed a melittin-RADA32 hybrid peptide hydrogel loaded with doxorubicin (DOX) potent chemoimmunotherapy against melanoma through the active regulation of TMEs. The formed melittin-RADA32-DOX (MRD) has interweaving nanofiber structure and exhibits excellent biocompatibility, controlled drug release properties both in vitro vivo, enhanced killing effect to cells. A...
Diabetic nephropathy (DN) is one of the main causes end-stage renal disease (ESRD). Existing treatments cannot control progression diabetic very well. In nephropathy, Many monocytes and macrophages infiltrate kidney tissue. However, role these cells in pathogenesis has not been fully elucidated. this study, we analyzed patient biopsy specimens, model animals. Meanwhile, cocultured found that damaged intrinsic (glomerular mesangial tubular epithelial cells) recruited monocytes/macrophages to...
Abstract Both lytic and apoptotic cell death remove senescent damaged cells in living organisms. However, they elicit contrasting pro- anti-inflammatory responses, respectively. The precise cellular mechanism that governs the choice between these two modes of remains incompletely understood. Here we identify Gasdermin E (GSDME) as a master switch for neutrophil pyroptotic death. tightly regulated GSDME cleavage activation aging neutrophils are mediated by proteinase-3 caspase-3, leading to...
Serum resistance, an important virulence determinant of Borrelia burgdorferi sensu lato strains belonging to the afzelii and B. stricto genotypes, is related binding complement inhibitor factor H spirochete surface protein outer E (OspE) its homologues. In this study, we show that C-terminal short consensus repeats 18-20 both human mouse bind OspE. Analogously, H-related 1, a distinct plasma with three repeat domains homologous those in H, bound Deleting 15-aa residues (region V) from C...
Abstract Background The significance of S100A8/A9 and S100A12 in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has not been clarified. This study was dedicated to exploring the potential pathogenic roles patients with myeloperoxidase (MPO)-ANCA-positive vasculitis. Methods Serum urine concentrations forty-two AAV were evaluated. influence on chemotaxis, apoptosis, release IL-1β, complement activation, respiratory burst, as well neutrophil extracellular traps (NETs)...
Although no study has directly shown the relationship between bacterial vaginosis (BV) and homocysteine (HCY), we still found some association these two through extensive literature data analysis. BV score was calculated by Nugent's method, less than equal to 6 is negative greater 7 positive. This article describes interrelationships mined from extracted NHANES regarding HCY under multiple covariates. We used cycles of 2001-2002 2003-2004 in our study. included 2398 participants who recently...
Gliomas are the most common tumors of central nervous system and classified into grades I-IV based on their histological characteristics. Lower-grade gliomas (LGG) can be divided grade II diffuse low-grade III moderate have a relatively good prognosis. However, LGG often develops high-grade glioma within few years. This study aimed to construct identify prognostic value an inflammatory signature discover potential drug targets for primary LGG. We first screened differentially expressed genes...
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