A5038580651- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Renal and related cancers
- Organ Transplantation Techniques and Outcomes
- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Plant-Microbe Interactions and Immunity
- Cancer-related molecular mechanisms research
- Microbial Metabolic Engineering and Bioproduction
- Microbial Natural Products and Biosynthesis
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Plant-Derived Bioactive Compounds
- Drug Transport and Resistance Mechanisms
- Plant tissue culture and regeneration
- Liver Disease Diagnosis and Treatment
- Insect Resistance and Genetics
- Polyamine Metabolism and Applications
- RNA Interference and Gene Delivery
- Telomeres, Telomerase, and Senescence
- Circular RNAs in diseases
- Cassava research and cyanide
Nankai University
2017-2025
Tianjin Central Hospital of Gynecology Obstetrics
2020-2025
Shenzhen Second People's Hospital
2023-2024
Army Medical University
2011-2023
Southwest Hospital
2011-2023
Chengdu University
2023
Peking University
2021-2023
Peking University Third Hospital
2021-2023
Hunan Normal University
2020-2022
Jiangxi Provincial Children's Hospital
2022
•Tsc1 deficiency facilitates p53 (haplo)insufficiency-mediated activation of the PTEN/Akt/mTOR axis to drive HCC tumorigenesis and metastasis.•Inhibiting mTOR is a potential therapeutic strategy for insufficiency Tsc1 insufficiency-driven hepatocarcinogenesis.•The oncogenic activity Akt/mTOR relies on Abcc4, which labels an aggressive subtype human HCC. Background & Aimsp53 mutations occur frequently in Activation mammalian target rapamycin (mTOR) pathway also associated with However, it...
Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133+ EpCAM+ CSCs HCC, although it is unclear whether miRNAs regulate CD90+ HCC.The miRNA profiles CD90- HCC were analyzed using a microarray quantitative real-time PCR (qRT-PCR). CSC characteristics examined by qRT-PCR Western blot pluripotency-associated genes, clone sphere formation assay, transwell migration nude mice...
Abstract Due to the lack of effective diagnostic tools, most patients with cholangiocarcinoma (CCA) have no chance surgical resection. Ars2 is a protein that was reported be important for microRNA (miR) biogenesis, and its depletion can reduce levels several miRs, including miR‐21, which overexpressed in CCAs. We hypothesized also present CCAs could an early marker. In our experiments, Ars2, PTEN, PDCD4, miR‐21 were evaluated 18 paired normal tissues. ShArs2, mimics, transfected into CCA...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with very poor prognosis. Therefore, it important to fully understand the molecular mechanism underlying its occurrence and development. Pumilio RNA-binding family member 1 (PUM1) has been reported function as an oncogene in ovarian cancer nonsmall cell lung cancer. However, role PDAC have not illuminated. Here, we found that PUM1 protein levels were higher tissues than adjacent significantly associated TNM stage overall...
Abstract Numerous long noncoding RNAs (lncRNAs) are aberrantly expressed in pancreatic cancer (PC); however, their functions and mechanisms progression largely unknown. In this study, we identified a novel PC-associated lncRNA, RUNX1-IT1, that was significantly upregulated PC patient samples from multiple centers associated with poor prognosis. vitro vivo, alterations RUNX1-IT1 expression markedly affected proliferation, migration invasion. contributed to the of by interacting adjacent gene...
The appearance of trophectoderm (TE) is a hallmark event in preimplantation development during murine embryogenesis. However, little known about the mechanisms underlying TE specification. We find that depletion Rif1 breaks down barrier to transition from embryonic stem cells (ESCs) trophoblast (TSCs). Rif1-null-induced TSCs show typical properties and potential differentiate into terminal lineages. Global transcriptome analysis reveal deletion activates 2-cell embryo (2C)-related genes...
Owing to their single genome, haploid cells are powerful uncover unknown genes by performing genetic screening in mammals. However, no cell line from an extraembryonic lineage has been achieved yet, which limits the application of placental screening. Here, we show that overexpression Cdx2 can convert embryonic stem trophoblast (TSCs). p53 deletion reduces diploidization during conversion and guarantees generation haploid-induced TSCs (haiTSCs). haiTSCs not only share same molecular...
Telomere length (TL) shortening is a pivotal indicator of biological aging and associated with many human diseases. The genetic determinates TL have been widely investigated, however, most existing studies were conducted based on adult tissues which are heavily influenced by lifetime exposure. Based the analyses terminal restriction fragment (TRF) telomere, individual genotypes, gene expressions 166 healthy placental tissues, we systematically interrogate TL-modulated genes their potential...
Preterm prelabor rupture of membranes (pPROM) is a leading cause neonatal morbidity and mortality. While intra-amniotic infection well-established driver pPROM, the role sterile inflammation remains unclear. Recent evidence suggests that interleukin-1 beta (IL-1β) promotes extracellular matrix (ECM) remodeling via downstream effectors, disintegrin-like metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9), while protein O-fucosyltransferase 2 (POFUT2) facilitates its...
Variations of the ABCB4 and ABCB11 genes affect composition bile are associated with cholestasis cholelithiasis. However, their roles in formation primary intrahepatic stones (PIS) remains to be elucidated. The aim present study was determine whether there is an association between PIS variations these genes. Exon sequencing performed order analyze 176 patients 178 healthy subjects. One mutation (no. 69233, G>A) two other mutations ABCB11, reference single nucleotide polymorphism...
Eight new neo-clerodane diterpenoids (1–8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted definition their structures, and experimental calculated electronic circular dichroism used to define absolute configurations. Compounds 2 4–8 found have NO inhibitory effects with IC50 values 20.2, 45.5, 34.0, 27.0, 45.0, 25.8 μM, respectively. The more potent compounds 2, 6, 8 analyzed establish anti-inflammatory mechanism, including regulation expression...