A5024628817- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Prenatal Screening and Diagnostics
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Renal and related cancers
- Reproductive System and Pregnancy
- Neurogenesis and neuroplasticity mechanisms
- Circular RNAs in diseases
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Telomeres, Telomerase, and Senescence
- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Ectopic Pregnancy Diagnosis and Management
- Muscle Physiology and Disorders
- Neonatal and Maternal Infections
- Radiopharmaceutical Chemistry and Applications
- Cardiac Structural Anomalies and Repair
- Congenital heart defects research
Tianjin Central Hospital of Gynecology Obstetrics
2021-2025
Nankai University
2017-2025
State Key Laboratory of Medicinal Chemical Biology
2021
Tianjin Medical University
2013
Abstract Tissue‐resident cardiac macrophage subsets mediate tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing macrophages have phenotypical similarities to M1‐polarized macrophages, are pro‐inflammatory, recruit CCR2 + circulating monocytes infarcted myocardium. Small extracellular vesicles (sEV) from ̶ which phenotypically resemble M2‐polarized promote anti‐inflammatory activity repair. Here, the authors harvested M2...
Intervertebral disc degeneration (IDD), being the predominant root cause of lower back pain, has led to an enormous socioeconomic burden in world. Ferroptosis is iron-dependent nonapoptotic and nonpyroptotic programmed cell death associated with increase reactive oxygen species (ROS), which been implicated pathogenesis IDD. Activation transcription factor 3 (ATF3) widely reported promote ferroptosis apoptosis multiple diseases, but its roles underlying regulatory mechanism IDD have not...
The abnormal function of nucleus pulposus cells (NPCs) plays a crucial role in the pathogenesis intervertebral disc degeneration (IVDD). Recent studies have demonstrated that circular RNAs (circRNAs) are involved pathological process IVDD by regulating NPCs’ function. Nevertheless, investigation on circRNA-circRNA interaction has not yet been reported. Here, we identified top upregulated circ_0040039 and circ_0004354 IVDD, derived from syntrophin beta 2 gene but had different degrees...
Abstract Background Resistance to androgen deprivation therapy remains a major challenge for the clinical treatment of patients with castration-resistant prostate cancer (CRPC). CYP1B1, critical enzyme that catalyzes conversion estradiol 4-Hydroxy-17β-estradiol (4-OHE2), has been reported promote development and progression hormone-related cancer, but its role in CRPC is unclear. Methods To explore underlying mechanism which CYP1B1 promotes stem cells (PCSCs) characteristics, bioinformatics...
Prostate cancer (PCa) is the second leading cause of mortality and a malignant tumors in males. stem cells (PCSCs) are likely responsible cell types for initiation, clinical treatment failure, tumor relapse, metastasis. Estrogen receptor alpha (ERα) mainly expressed basal layer normal prostate gland has key roles coordinating to control organ development. Here, we investigated estrogen-ERα signaling pathway regulating PCSCs.Correlation CD49f ERα/NOTCH1 was analyzed human datasets tissue...
Abstract Cancer‐associated fibroblasts (CAFs) can promote the development and metastasis of prostate cancer partly by mediating tumor‐associated inflammation. An increasing amount studies have focused on functional interactions between CAFs immune cells in tumor microenvironment (TME). We previously reported that G protein‐coupled receptor 30 (GPR30) was highly expressed plays a crucial role stromal cell activation. However, effect underlying mechanism GPR30 expression affecting interaction...
Telomere length (TL) shortening is a pivotal indicator of biological aging and associated with many human diseases. The genetic determinates TL have been widely investigated, however, most existing studies were conducted based on adult tissues which are heavily influenced by lifetime exposure. Based the analyses terminal restriction fragment (TRF) telomere, individual genotypes, gene expressions 166 healthy placental tissues, we systematically interrogate TL-modulated genes their potential...
Preterm prelabor rupture of membranes (pPROM) is a leading cause neonatal morbidity and mortality. While intra-amniotic infection well-established driver pPROM, the role sterile inflammation remains unclear. Recent evidence suggests that interleukin-1 beta (IL-1β) promotes extracellular matrix (ECM) remodeling via downstream effectors, disintegrin-like metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9), while protein O-fucosyltransferase 2 (POFUT2) facilitates its...
Abstract Objective: To analyze fetal renal abnormality genetic features and the prenatal characteristics of 17q12 microdeletion syndrome. Methods: This prospective cohort study examined ultrasound findings abnormalities in pregnant women who underwent single nucleotide polymorphism (SNP) array or copy number variation sequencing (CNV-seq) testing on amniotic fluid tissue at Tianjin Central Obstetrics Gynecology Hospital between January 2016 August 2022. The comprised with advanced maternal...
Bicalutamide is a nonsteroidal antiandrogen widely used as first-line clinical treatment for advanced prostate cancer (PCa). Although patients initially show effective responses to bicalutamide treatment, resistance frequently occurs and leads the development of castration-resistant PCa (CRPC). This research investigated roles oestrogen receptor α (ERα)-nuclear factor E2-related 2 (NRF2) signalling pathway in cells.We performed bioinformatic analysis immunohistochemical staining on normal...
Abstract Yes-associated protein (YAP) is a pivotal regulator in cellular proliferation, survival, differentiation, and migration, with significant roles embryonic development, tissue repair, tumorigenesis. At the maternal–fetal interface, emerging evidence underscores importance of precisely regulated YAP activity ensuring successful pregnancy initiation progression. However, despite established association between dysregulation adverse outcomes, insights into impact aberrant levels...
Prostate cancer (PCa) is a leading cause of cancer‑associated mortality in men; however, the factors that contribute to disease development have yet be fully elucidated. Previous studies suggested prohibitin-2 (PHB2), which multifunctional protein contributes various cellular processes, positively correlated with malignant progression PCa; molecular mechanisms underlying effects PHB2 on enhancement cell migration not been identified. The present study induced overexpression and knockdown PCa...
The promising therapeutic strategy for the treatment of peripheral artery disease (PAD) is to restore blood supply and promote regeneration skeletal muscle regeneration. Increasing evidence revealed that prostaglandin E2 (PGE2), a lipid signaling molecule, has significant potential tissue repair Though PGE2 been well reported in regeneration, application hampered by its short half-life vivo lack viable system sustained release PGE2.In this study, we designed synthesized new matrix chemically...
Abstract Preeclampsia (PE) is the most common medical complication during pregnancy and second leading cause of maternal death worldwide. However, a better predictive model PE remains to be explored. A total 15 severe preeclampsia (sPE) 75 healthy control patients were included in this study. Patient data was obtained from September 2019 2021. Nuchal translucency (NT) crown‐rump length (CRL) fetus acquired by ultrasound. Maternal blood samples collected at 11 +0 13 +6 weeks gestation....
Treatment of patients with castration-resistant prostate cancer (CRPC) remains a major clinical challenge. We previously showed that estrogenic effects contribute to CRPC progression and are primarily caused by the increased endogenous estradiol produced via highly expressed aromatase. However, mechanism aromatase upregulation its role in poorly described. In this study, we report HeyL is aberrantly upregulated tissues, expression positively correlated levels. overexpression levels estrogen...
Abstract In 2019, preterm births (PTB) accounted for approximately 0.66 million deaths globally. PTB is also associated with a significantly higher risk of mortality and long-term complications newborns. Long-term studies several factors, including disruption immune tolerance inflammation, PTB. However, the pathogenesis remains unclear. Gonadal steroid hormones are critical pregnancy maintenance regulation inflammatory responses. it not clear how unbalanced gonadal hormones, such as...
Steroid hormones, including progestagens, estrogens, androgens, corticosteroids, and their precursor cholesterol, perform essential functions in the successful establishment maintenance of pregnancy normal fetal development. As core endocrine organ at prenatal stage, human placenta is involved biosynthesis, metabolism, delivery steroid hormones. Steroidogenic pathways are tightly regulated by placenta-intrinsic cytochrome P450 hydroxysteroid dehydrogenase. However, relationship between...
Fetal membrane providing mechanical support and immune protection for the growing fetus until it ruptures during parturition. The abnormalities of fetal (thickening, separation, etc.) are related to adverse perinatal outcomes such as premature delivery, deformities death. As a noninvasive method, imaging methods play an important role in prenatal examination. In this paper, we comprehensively reviewed manuscripts on method their potential predicting prognosis. We also discussed prospect...