A5014015791- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Pregnancy-related medical research
- Cancer-related molecular mechanisms research
Tianjin Hospital
2022
Tianjin Medical University
2022
Tianjin Medical University General Hospital
2021
Intervertebral disc degeneration (IDD), being the predominant root cause of lower back pain, has led to an enormous socioeconomic burden in world. Ferroptosis is iron-dependent nonapoptotic and nonpyroptotic programmed cell death associated with increase reactive oxygen species (ROS), which been implicated pathogenesis IDD. Activation transcription factor 3 (ATF3) widely reported promote ferroptosis apoptosis multiple diseases, but its roles underlying regulatory mechanism IDD have not...
The abnormal function of nucleus pulposus cells (NPCs) plays a crucial role in the pathogenesis intervertebral disc degeneration (IVDD). Recent studies have demonstrated that circular RNAs (circRNAs) are involved pathological process IVDD by regulating NPCs’ function. Nevertheless, investigation on circRNA-circRNA interaction has not yet been reported. Here, we identified top upregulated circ_0040039 and circ_0004354 IVDD, derived from syntrophin beta 2 gene but had different degrees...