A5102895970- Pluripotent Stem Cells Research
- Photodynamic Therapy Research Studies
- Cancer Immunotherapy and Biomarkers
- Neurogenesis and neuroplasticity mechanisms
- Nanoplatforms for cancer theranostics
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pregnancy and preeclampsia studies
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Photoacoustic and Ultrasonic Imaging
- Global Cancer Incidence and Screening
- Optical Imaging and Spectroscopy Techniques
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Reproductive System and Pregnancy
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Trauma and Emergency Care Studies
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
- Maternal and fetal healthcare
- Cancer, Hypoxia, and Metabolism
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Risk Factors
Tianjin Medical University Cancer Institute and Hospital
2020-2025
Beijing Jishuitan Hospital
2025
Xuzhou Central Hospital
2022-2025
Capital Medical University
2025
Peking University
2025
Beijing University of Technology
2021-2024
Southern Medical University
2009-2024
Nanfang Hospital
2009-2024
University Hospital Bonn
2024
University of Bonn
2018-2024
Clinical application of stem cell derivatives requires clinical-grade cells and sufficient preclinical proof safety efficacy, preferably in primates. We previously successfully established a human parthenogenetic embryonic (hPESC) line, but the suitability its subtype-specific progenies for therapy is not clear. Here, we compared function hPESC-derived midbrain dopaminergic (DA) neurons two canonical protocols primate Parkinson's disease (PD) model. found that grafts did form tumors produced...
Abstract Preeclampsia (PE) is a multisystem disorder with high maternal morbidity and mortality rates. Currently, no practical therapeutic approach available to prevent PE progression, except for early delivery. Gut dysbiosis associated development. Previous data showed that the abundance of Akkermansia muciniphila ( Am ) was lower in patients than normotensive pregnant women. Here, this study, decreased observed mouse model. Also, we found administration could significantly attenuate...
Previous studies focused more on the short-term risk of cardiovascular (CV) death due to traumatic psychological stress after a cancer diagnosis and acute cardiotoxicity anticancer treatments than long-term CV death.Time trends in proportions (PCV), (PCA), other causes deaths from all were used show preliminary relationships among three 4,806,064 patients with Surveillance, Epidemiology, End Results (SEER) program. Competing mortality curves investigate when cumulative rate (CMRCV) began...
Micro(nano)plastics (MNPs) are emerging pollutants that can adsorb in the environment and biological molecules ultimately affect human health. However, aspects of adsorption intracellular proteins onto MNPs its effects cells have not been investigated to date. The present study revealed 100 nm polystyrene nanoplastics (NPs) could be internalized by THP-1 specifically adsorbed proteins. In total, 773 NPs with high reliability were identified using proteomics approach analyzed via...
Abstract Background: Thyroid cancer (TC) is the most common malignancy of endocrine system. This study aimed to assess global distribution TC incidence and mortality in 2022, as well predict burden for year 2050. Methods: Data from GLOBOCAN 2022 database were used analyze age-standardized rates by sex, age group (<55 years ≥55 years), country, world region, level Human Development Index (HDI) 185 countries. The predicted 2050 was calculated based on demographic projections. Results: In an...
An improved method to estimate dose esophageal tissue was investigated in the setting of photodynamic therapy with aminolevulinic acid-induced protoporphyrin IX (PpIX) treatment. A model treatment-induced edema esophagus mucosa proved be a well controlled and useful way test dosimetry model, light from treatment laser together PpIX fluorescence intensity could quantified reliably real time. Dosimetry calculations based upon detected bleaching kinetics were used calculate "effective" tissue,...
Recent reports suggest that induced neurons (iNs), but not pluripotent stem cell (iPSC)-derived neurons, largely preserve age-associated traits. Here, we report on the extent of preserved epigenetic and transcriptional aging signatures in directly converted neural cells (iNSCs). Employing restricted integration-free expression SOX2 c-MYC, generated a fully functional, bona fide NSC population from adult blood remains highly responsive to regional patterning cues. Upon conversion, low passage...
Abstract Immune checkpoint inhibitors (ICIs) are most commonly used for melanoma and non-small cell lung cancer (NSCLC) patients. FAT atypical cadherin 1 (FAT1), which frequently mutates in NSCLC. In this study, we aim to investigate the association of FAT1 mutations with ICI response outcome. We collected somatic mutation profiles clinical information from ICI-treated 631 109 NSCLC samples, respectively. For validation, a pan-cancer cohort 1661 patients an immunotherapy setting was also...
Abstract Purpose Protein tyrosine phosphatase receptor type T (PTPRT), which is a well‐known and mutates frequently in melanoma non‐small cell lung cancer (NSCLC). Our research aims to elucidate its mutation association with immune checkpoint inhibitors (ICI) efficacy. Methods We integrated whole‐exome sequencing (WES) ‐ based somatic profiles clinical characteristics of 631 samples received ICI agents from eight studies 109 NSCLC two studies. For validation, 321 350 immunotherapy targeted...
Background Immune checkpoint inhibitor (ICI) therapy dramatically prolongs melanoma survival. Currently, the identified ICI markers are sometimes ineffective. The objective of this study was to identify novel determinants efficacy. Methods We comprehensively curated pretreatment somatic mutational profiles and clinical information from 631 patients who received blockade immune checkpoints (i.e., CTLA-4, PD-1/PD-L1, or a combination). Significantly mutated genes (SMGs), signatures, potential...
Background: Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. Because the diversity IR applied in medicine, agriculture, industry, and growing threats global terrorism, acquisition radioprotectors is an urgent need for nation. However, applicability currently under investigation limited due their inherent toxicity. Objective: This study investigated effect a standardized North...
Despite the acknowledged sex-related differences in immune response and checkpoint inhibitor (ICI) efficacy, little is known about sex disparities melanoma of novel genomic determinants for ICI therapies.Pretreatment profiles clinical characteristics 631 patients treated with ICIs (i.e., inhibitors CTLA-4, PD-1/PD-L1, or both) were comprehensively curated. Genomic factors, i.e., significantly mutated genes (SMGs), mutational signatures, molecular subtypes identified, their associations...
Fluorescence measurements have been used to track the dosimetry of photodynamic therapy (PDT) for many years, and this approach can be especially important treatments with aminolevulinic-acid-induced protoporphyrin IX (ALA-PpIX). PpIX photobleaches rapidly, bleaching is known oxygen dependent, at same time, fractionation or reduced irradiance shown significantly increase efficacy. Thus, in vivo measurement either rate and/or total yield could deposited dose tissue determine optimal treatment...
Lmx1a plays a central role in the specification of dopaminergic (DA) neurons, which potentially could be employed as key factor for trans-differentiation to DA neurons. In our previous study, we have converted somatic cells directly into neural stem cell—like cells, namely induced (iNSCs), further can differentiated subtypes neurons and glia vitro. present continued test whether these iNSCs therapeutic effects when transplanted mouse model Parkinson's disease (PD), especially was introduced...
Preeclampsia is a common obstetric disorder affecting 2-8% of pregnancy worldwide. Fibrosis an important histological change occurring in preeclamptic placenta, and might depend on the excess deposition collagen I. However, role fibrotic placenta I pathogenesis preeclampsia remains unclear. Therefore, we analyzed expression Collagen human by Masson staining, Sirius red staining western blotting. Further, was studied C57BL/6 mice. HTR-8/SVneo cells were used to investigate mechanisms...
To determine whether risk stratification can optimize the benefits of flexible sigmoidoscopy (FSG) screening.
Background: Acute ischemic stroke (AIS) is a prevalent and challenging neurological condition associated with high mortality morbidity rates. This study aimed to evaluate the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) combined ginkgo diterpene lactone meglumine injection (GDLMI) on cognitive function recovery in patients AIS. Methods: A total 120 AIS, admitted between January 2021 2022, received rTMS GDLMI after admission. Their functions were assessed using...
Background: Currently, large-sample epidemiological studies on congenital upper limb differences (CULD) in China are relatively rare. This report presents our centre’s experience the spectrum of diseases and related factors. Methods: Information was collected from patients with CULD who underwent surgical treatment at centre September 2018 to October 2023. Data collection included patient name, gender, age, clinical features diagnosis, family history, parents’ medical pregnancy history...