A5060733420- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Peroxisome Proliferator-Activated Receptors
- Reproductive Physiology in Livestock
- Ruminant Nutrition and Digestive Physiology
- Chromatography in Natural Products
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Sphingolipid Metabolism and Signaling
- Alzheimer's disease research and treatments
- Alcoholism and Thiamine Deficiency
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Growth Hormone and Insulin-like Growth Factors
- Ginseng Biological Effects and Applications
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plant Pharmacodynamics Research
- Inflammasome and immune disorders
- Phytochemical Studies and Bioactivities
- Cholesterol and Lipid Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
Jilin University
2016-2023
Jilin Medical University
2021
Athinoula A. Martinos Center for Biomedical Imaging
2019
Harvard University
2019
Massachusetts General Hospital
2019
Background/Aims: Dairy cows with ketosis are characterized by oxidative stress and hepatic damage. The aim of this study was to investigate the apoptotic status ketotic cows, as well underlying apoptosis pathway. Methods: blood aspartate aminotransferase (AST), alanine (ALT), glutamate dehydrogenase (GLDH) gamma-glutamyl transferase (GGT) activities haptoglobin (HP), serum amyloid A (SAA) cytokeratin 18 neo-epitope M30 (CK18 M30) concentrations were determined commercially available kits...
Identifying safe and effective compounds that target to mitophagy eliminate impaired mitochondria may be an attractive therapeutic strategy for non-alcoholic fatty liver disease. Here, we investigated the effects of cyanidin-3-O-glucoside (C3G) on disease (NAFLD) underlying mechanism.Non-alcoholic was induced by a high-fat diet 16 weeks. C3G administered during last 4 In vivo, recombinant adenoviruses AAV8 were used overexpression knockdown PTEN-induced kinase 1 (PINK1), respectively. AML-12...
The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation hepatic metabolism to overcome metabolic stress. Fatty liver is one main health disorders after parturition. Therefore, investigate changes lipid status mitochondria dairy cows with mild fatty liver, blood samples were collected from healthy (n = 15) 15). To determine effects palmitic acids (PA), major component acids, on vitro, calf hepatocytes isolated calves treated various...
Acetaminophen (APAP) overdose is a major cause of liver injury. Neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) an E3 ubiquitin ligase that has been implicated in the pathogenesis numerous diseases; however, its role APAP-induced injury (AILI) unclear. Thus, this study aimed to investigate NEDD4-1 AILI. We found was dramatically response APAP treatment mouse livers and isolated hepatocytes. Hepatocyte-specific knockout exacerbated mitochondrial damage resultant...
This study provides evidence that nuciferine exerts anti-obesity effects in mice fed a high fat diet by reducing the intestinal permeability <italic>via</italic> enhancement of autophagy and increasing relative abundance <italic>Akkermansia</italic>.
Reduced feed intake during the transition period renders cows unable to meet their energy needs for maintenance and lactation, leading a state of negative balance. Severe balance initiates fat mobilization increases circulating levels free fatty acids (FFA), which could induce hepatic mitochondrial dysfunction, oxidative stress, apoptosis. Enhancing supply propionate (major gluconeogenic substrate) is feasible preventive therapeutic strategy alleviate metabolic disorders period. Whether...
During the transition period in dairy cows, high circulating concentrations of nonesterified fatty acids (NEFA) increase hepatic lipid deposits and are considered a major pathological factor for liver damage. We investigated whether AdipoRon, synthetic small-molecule agonist adiponectin receptors 1 2 shown to prevent accumulation nonruminants, could alleviate NEFA-induced mitochondrial dysfunction. Bovine hepatocytes were isolated from 5 healthy Holstein female newborn calves (1 d age, 30–40...
High blood concentrations of nonesterified fatty acids (NEFAs) provoke various metabolic disorders and are associated with mammary tissue injury decreased milk production in dairy cows. Nuciferine, an alkaloid found Nelumbo nucifera leaves, has great potential for correcting lipid metabolism derangements lipotoxicity. In this study, we evaluated the lipotoxicity induced by excessive NEFA bovine epithelial cells (bMECs) investigated whether nuciferine alleviates NEFA-induced underlying...
Fatty liver is a major metabolic disorder of high-producing dairy cows during the transition period. In nonruminants, it well established that insulin-induced gene 1 (INSIG1) plays crucial role in regulating hepatic lipogenesis by controlling anchoring sterol regulatory element-binding protein (SREBP-1) on endoplasmic reticulum along with SREBP cleavage-activating (SCAP). Whether INSIG1-SCAP-SREBP-1c transport axis affected experiencing fatty unknown. Thus, aim this study was to investigate...
When ketosis occurs, supraphysiological concentrations of nonesterified fatty acids (NEFA) display lipotoxicity and are closely related to the occurrence hepatic lipid accumulation, oxidative stress, inflammation, resulting in damage exacerbating progression ketosis. However, mechanism these lipotoxic effects caused by high NEFA is still unclear. Cluster antigen 36 (CD36), a acid transporter, plays vital role development pathological injury nonruminants. Thus, aim this study was investigate...
Abstract Innate immune suppression and high blood fatty acid levels are the pathological basis of multiple metabolic diseases. Neutrophil vacuolation is an indicator status patients, which associated with autophagy-dependent granule degradation. Vacuolated neutrophils observed in ethanol toxicity septicemia patients due to changes their constituents, but how about nonalcoholic liver disease (NAFLD) patient unknown. Here, we confirmed that adhesion deficiency increased autophagy level existed...