A5101912897- Bariatric Surgery and Outcomes
- Gastric Cancer Management and Outcomes
- Ovarian function and disorders
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diet and metabolism studies
- Obstructive Sleep Apnea Research
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Aquaculture Nutrition and Growth
- Lipid metabolism and disorders
- Reproductive System and Pregnancy
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Neuroscience of respiration and sleep
- Diet, Metabolism, and Disease
- Orthopedic Surgery and Rehabilitation
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Advancements in Semiconductor Devices and Circuit Design
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
Columbia University Irving Medical Center
2023-2025
Central South University
2025
Ruijin Hospital
2014-2024
Shanghai Jiao Tong University
2024
Qilu Hospital of Shandong University
2016-2024
Shandong University
2023-2024
Guangzhou Medical University
2024
West China Second University Hospital of Sichuan University
2024
Gansu Provincial Hospital
2024
Gansu Provincial Center for Disease Control and Prevention
2024
Abstract Purpose: We report the intracranial efficacy of selpercatinib, a highly potent and selective RET inhibitor, approved in United States for fusion-positive non–small cell lung cancers (NSCLC). Patients Methods: In global phase 1/2 LIBRETTO-001 trial (NCT03157128) advanced RET-altered solid tumors, selpercatinib was dosed orally (160 mg twice every day) 28-day cycles. with baseline metastases had MRI/CT scans 8 weeks 1 year (12 thereafter). this pre-planned analysis patients NSCLC...
Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes, which characterized by both systolic and diastolic dysfunction. The effective treatment strategy for DCM has not been developed. Rats were divided into 3 groups different treatment. control group was only injected citrate buffer (n = 8). diabetes treated streptozotocin to induce diabetes. After success induction, rats (diabetes group, n 8) or without recombinant human Neuregulin-1 (rhNRG-1). All studies...
Abstract Identifying relevant mediators responsible for the pathogenesis during sepsis may lead to finding novel diagnostic and therapeutic targets. Recent studies indicate programmed cell death receptor (PD)-1 plays a significant role in development of immune suppression associated with sepsis. In this study, we determine whether B7-H1, primary ligand PD-1, contributes We report that B7-H1 is upregulated extensively on various cells gene deficiency protects mice from lethality terms...
Abstract Background When analyzing the relationship between adenotonsillar hypertrophy and craniofacial morphology, researchers generally regarded hypertrophied adenoids tonsils as a whole. It remains unclear whether different enlarged sites of pharyngeal lymphoid tissue would correlate with multiple subtypes. We hypothesized there be subtypes correlated locations adenoid tonsil. Methods Lateral cephalometric radiographs were obtained from 466 children (171 boys 295 girls, aged 12.27 ± 2.69...
Improved β-cell function seems to be essential for better glucose homeostasis after Roux-en-Y gastric bypass but is less studied sleeve gastrectomy (SG). We evaluated the effects of SG on in obese patients with diabetes (DM group) and without (control response both oral intravenous stimulation. The DM group demonstrated impaired insulin sensitivity before surgery. index groups significantly improved SG. In addition, (early insulinogenic tolerance test acute an test) increased decreased...
Objective: Bariatric surgery can profoundly improve glucose and lipid metabolism in diabetic rats. Fibroblast growth factor 21 (FGF21) is an important hormone with multiple metabolic beneficial effects. Alteration serum FGF21 level after bariatric has been reported conflicting results. Here, we investigated the effect of surgeries on expression sensitivity. Methods: We performed duodenal-jejunal bypass (DJB), sleeve gastrectomy (SG) sham rats induced by high fat diet streptozotocin....
The gate-all-around (GAA) silicon nanowire transistor (SNWT) is considered as one of the best candidates for ultimately scaled CMOS devices at end technology roadmap. This paper reviews our recent work on characterization and analysis this unique one-dimensional nanowire-channel device with three-dimensional surrounding-gate from experiments simulation, including carrier transport behavior, parasitic effects, noise characteristics, self-heating effect, variability reliability, which can...
To analyze the prognostic value and potential target for therapeutic intervention of enhancer zeste homologue 2 (EZH2) in uveal melanomas (UM) patients.We analyzed EZH2 expression 89 primary UM patients by immuno- histochemistry to observe clinicopathological EZH2.The high levels mitoses count Ki67 labeling index had significant correlation with overexpression (R = 0.408, P.Our critical finding is that can be served as predictive marker associated adverse clinical outcomes. Further...
No sex-specific guidelines for surgical anti-obesity strategies have been proposed, partially due to the controversy regarding sex-related differences in weight loss after bariatric metabolic surgery.
In this paper, the characteristic variability in gate-all-around (GAA) silicon nanowire MOSFETs (SNWTs) is experimentally studied. Variation sources SNWTs are extracted for first time, taking into account strongly-confined geometry induced quantum effect, quasi-ballistic effects, as well parasitic resistance at interface of 1D channel and 3D wide S/D regions. The measured results show that with suppressed random dopant fluctuations (RDF) intrinsic channel, variations radius (R) metal-gate...
Cervical cancer is the principal cause of mortality due to in women worldwide. New predictive markers may increase survival rates by improving treatment patients at a high risk for cancer. This study was carried out investigate amplification human telomerase RNA component (hTERC) or/and c-MYC cervical epithelial exfoliated cells carcinoma screening. We collected 171 specimens. including speciments from normal cervix, benign lesions, intraepithelial neoplasia (CIN)1, CIN2 and CIN3, or situ,...
Duodenal-jejunal bypass (DJB) surgery has been reported to effectively relieve diabetic cardiomyopathy (DCM). However, the specific mechanisms remain largely unknown. The present study was designed determine alterations of myocardial glucose uptake (MGU) after DJB and their effects on DCM.Duodenal-jejunal sham surgeries were carried out in rats induced by a high-fat diet low dose streptozotocin, with chow-diet fed as controls. Bodyweight, food intake, homeostasis lipid profiles measured at...
This study investigated the effects of dietary lipid sources on juvenile blunt snout bream, Megalobrama amblycephala. Juvenile bream (14.40 ± 0.01 g) were fed diets containing 75 g/kg fish oil (FO), linseed (LO), soybean oil, coconut (CO), rapeseed or beef tallow (BT) for 9 weeks. Survival rates, final weight, weight gain, feed efficiency ratio and intake remained unchanged. Viscerosomatic ratio, hepatosomatic index condition factor highest in CO diet (p < 0.05). Whole-body content...
Bariatric surgery has been reported to relieve diabetic cardiomyopathy (DCM) effectively. However, the mechanisms remain largely unknown. To determine effects of bariatric on DCM via modulation myocardial Ca 2+ homeostasis and autophagy, sleeve gastrectomy (SG), duodenal-jejunal bypass (DJB), sham surgeries were performed in rats induced by high-fat diet a low dose streptozotocin. Cardiac remodeling was assessed series morphometric histological analyses. Transthoracic echocardiography...