A5100377198- interferon and immune responses
- DNA and Nucleic Acid Chemistry
- Inflammasome and immune disorders
- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Advanced Photocatalysis Techniques
- Nanopore and Nanochannel Transport Studies
- Genomics and Phylogenetic Studies
- Angiogenesis and VEGF in Cancer
- Electrostatics and Colloid Interactions
- Identification and Quantification in Food
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Systemic Lupus Erythematosus Research
- Genetic diversity and population structure
- Coronary Interventions and Diagnostics
- Immune Cell Function and Interaction
- Gas Sensing Nanomaterials and Sensors
- Surface Treatment and Residual Stress
- RNA regulation and disease
- Cardiac Fibrosis and Remodeling
- Extracellular vesicles in disease
Tongren Hospital
2023-2025
Southeast University
2023-2025
China Pharmaceutical University
2018-2025
Southern Medical University
2009-2025
Zhengzhou University of Aeronautics
2023-2025
Shandong Jianzhu University
2025
Changzhou University
2024
Nanjing Tech University
2024
Jiangsu University
2024
Shanghai Aerospace Automobile Electromechanical (China)
2024
Rheumatoid arthritis (RA) is a chronic autoimmune disease commonly associated with the accumulation of hyperactive immune cells (HICs), particularly macrophages pro-inflammatory (M1) phenotype, accompanied by elevated level reactive oxygen species (ROS), decreased pH and O2 content in joint synovium. In this work, an immunomodulatory nanosystem (IMN) developed for RA therapy modulating restoring function HICs inflamed tissues. Manganese tetraoxide nanoparticles (Mn3 O4 ) anchored on...
The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated boost antiviral innate immunity. Here, we report that responsible for DNA-induced ISG15 conjugation system. E3 HERC5 catalyzes ISGylation cytoplasmic at lysine 21, 187, 219, and 458, whereas Ubl carboxy-terminal hydrolase 18 removes cGAS. interaction depends on C-terminal domain RRC1-4 RRC1-5 domains HERC5. Mechanically,...
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein overexpressed in many malignancies. Its role the hepatocellular carcinoma (HCC) prognosis has not been investigated. In this study, we investigated whether TXNRD1 functions as an independent prognostic factor for HCC patients. We found was tissues and cells, immunohistochemical analysis suggested elevated 57 of 120 (47.5%) clinical samples, its level increased with increasing stage. addition, expression positively...
Stimulator of interferon genes (STING) is critical for cytosolic DNA-triggered innate immunity. STING modified by several types polyubiquitin chains. Here, we report that the deubiquitinase CYLD sustains signaling stabilizing protein. deficiency promoted K48-linked polyubiquitination and degradation STING, attenuating induction IRF3-responsive after HSV-1 infection or transfection DNA ligands. Additionally, knockout mice were more susceptible to than their wild-type (WT) littermates....
STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal adaptor protein CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I IFN production innate immunity. However, excessive or prolonged activation associated with autoinflammatory and autoimmune diseases. Thus, preventing from over-activation important to maintain immune homeostasis. Here, we reported that UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, was...
Controllable and sufficient concentrations of therapeutic agents in gene therapy are critical to achieve satisfactory outcomes. Herein, a Zn2+/Cu2+ bimetallic nano metal–organic framework loaded with rolling circle amplification (RCA) substrates (termed PZCT) was established for precise efficient DNAzyme-based chemo-dynamic combined therapy. The activation PZCT is bioorthogonally controlled by tumor-specific miR-21, which generates numerous DNAzyme silencing EGR-1 mRNA the assistance Zn2+...
Survivin, one of the strongest apoptosis inhibitors, plays a critical role in development and progression hepatocellular carcinoma (HCC). By comparison, relatively little is known about effect survivin gene polymorphisms on HCC susceptibility. Our study aimed to investigate association with risk Chinese han population.A case-control was conducted population consisting 178 cases 196 cancer-free controls. Information demographic data related factors collected for all subjects. Polymorphisms...
Complexation of graphene oxide (GO) and cetyltrimethylammonium bromide (CTAB), a model amphiphile, was quantitatively studied to elucidate the governing forces resulting structures their self-assembly. We systematically varied pertinent self-assembly parameters, including GO size, mixing ratio, salt, osmotic stress, quantified nanoscale GO:CTAB using X-ray diffraction. Multilamellar stacking CTAB layers persists in all assemblies exhibiting structural order. While driven by hydrophobic...
The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, activity cGAS must be tightly fine-tuned to maintain homeostasis antiviral response. Here, we reported that neddylation modification was indispensable for appropriate cGAS-STING signaling activation. Blocking pathway using inhibitor MLN4924 substantially impaired induction type I...
Background Adipocyte fatty acid-binding protein (A-FABP) has been described as a novel adipokine, playing an important role in the development of metabolic syndrome, type 2 diabetes and atherosclerosis. In this study, we investigated relationship between serum levels A-FABP presence severity coronary artery disease (CAD) Chinese subjects. Methodology/Principal Findings Circulating level was determined by ELISA 341 subjects (221 men, 120 women) who underwent angiography. patients with CAD...
Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation cGAS by self-DNA promotes severe autoinflammatory diseases such Aicardi–Goutières syndrome (AGS); thus, inhibition may provide therapeutic benefit in anti-autoimmunity. Here we report that perillaldehyde (PAH), natural monoterpenoid compound derived from Perilla frutescens , suppresses cytosolic-DNA-induced immune responses...
Gold–platinum nanoparticles with triple nanozyme activity combined photodynamic and photothermal effects for anti-tumor therapy.
Bismuth vanadate (BiVO4) is a potential photoelectrode for photoelectrochemical (PEC) applications. Nevertheless, the rapid charge recombination and sluggish water oxidation kinetics greatly limit PEC activity. To address these drawbacks, this study developed cooperative modification strategy with simultaneous La doping amorphous cobalt-phytate compound (Co-phy) as cocatalyst on BiVO4 to raise performance. increased donor density, decoration of Co-phy expedited further improved utilization...
The timely and accurate detection of cancer is crucial for preventing disease progression the early treatment confirmed cases. MiRNAs are markers. In this study, a simple miRNA method proposed. Three hairpins were designed based on gold nanoparticles combined with catalytic hairpin assembly nucleic acid amplification technology. low-pH was used rapid coupling, H1 opened by miR-378, triggering cycle reaction signal finally forming Y-shaped structure, thereby narrowing distance between...
Mastering the coupling relationship and driving mechanism between urbanization biodiversity is of great significance to ecological protection regional sustainable development. The study took areas along Yellow River Shandong province (AYRSP) as area, which have most rich unique resources in whole basin. First, this constructed a new indicator system based on remote-sensing data from species, ecosystem, landscape monitor evaluate spatial heterogeneity. result was quantified by proportion key...